Friday, September 12, 2014

Regulating nitric oxide production

Which way does your doctor recommend you get your nitric oxide?
Does your doctor even know the benefits of nitric oxide for stroke?

Modulation of Adult Neurogenesis by the Nitric Oxide System

Efficacy of Nitric Oxide in Stroke' (ENOS) study 

Inhaled Nitric Oxide Protects Males But not Females from Neonatal Mouse Hypoxia–Ischemia Brain Injury 

 

  Inhaled Nitric Oxide Protects Males But not Females from Neonatal Mouse Hypoxia–Ischemia Brain Injury

 

  Regulation of Injury-Induced Neurogenesis by Nitric Oxide

 

 Nitric Oxide and the Biological Cascades Underlying Increased Neurogenesis, Enhanced Learning Ability, and Academic Ability as an Effect of Increased Bouts of Physical Activity

  Inhalation of nitric oxide could help improve blood flow to ischemic brain

  Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function

 

  Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke

 

Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function



 And the latest here:
http://www.sciencemag.org/content/345/6202/1306.4.short
Blood vessels relax and enable increased blood flow when the enzyme eNOS produces nitric oxide (NO) in the endothelial cells lining the vessels. The activity of eNOS varies with modifications to specific sites in the enzyme, such as S-sulfhydration, a process that is triggered by the gas hydrogen sulfide (H2S). Altaany et al. found that S-sulfhydration of eNOS increased its activity by affecting other modifications to the enzyme. Endothelial cells from mice that could not produce H2S also produced less NO than those from normal mice. Enhancing the S-sulfhydration of eNOS may be an effective strategy to increase blood flow in patients.
Sci. Signal. 7, ra87 (2014).

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