Deans' stroke musings: Inhalation of nitric oxide could help improve blood flow to ischemic brain

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, March 5, 2012

Inhalation of nitric oxide could help improve blood flow to ischemic brain

Previous research into NO received the Nobel prize.

The Nobel Assembly at Karolinska Institutet has today decided to award
the Nobel Prize in Physiology or Medicine for 1998 jointly to

Robert F. Furchgott, Louis J. Ignarro and Ferid Murad

for their discoveries concerning "nitric oxide as a signalling molecule in the cardiovascular system".

This was already referred to here in 2006
The latest here:
http://www.news-medical.net/news/20120305/Inhalation-of-nitric-oxide-could-help-improve-blood-flow-to-ischemic-brain.aspx

LMU researchers developed a new strategy for the treatment of stroke, which could help to improve blood flow to ischemic brain. Strokes are due to a localized reduction in the blood supply to the brain, mainly due to the blockage of a vessel by a blood clot.

This can lead to the death and irreversible loss of nerve cells. In about 90% of cases, no dedicated treatment is available that can effectively prevent serious damage following an acute stroke. A team led by LMU researcher Professor Nikolaus Plesnila has now shown, in an animal model, that inhalation of nitric oxide (NO), a chemical compound which is itself toxic, can improve perfusion of the brain in the aftermath of an acute stroke. Brain function in treated animals was significantly improved as compared to in controls that had not been given NO.

"In collaboration with colleagues at Harvard Medical School, we have just begun to test whether or not NO has a comparable effect in humans. If so, we could then initiate a full-scale international clinical study," says Plesnila.

"If such a trial were successful, the new therapy could be introduced into the clinic very quickly. NO is already widely used for the management of several lung diseases, and could even be administered as required in ambulances and other rescue vehicles."