Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement

Not to be done on your own. You know how dangerous eating food is without a doctors prescription. Of course your doctor will never get around to creating a stroke food protocol, which will make no difference since you will have lost the memory of this good idea. Isn't it much better being stupid? Less to think about.
http://link.springer.com/article/10.1007/s11481-016-9693-6

• Khushbu K. Modi
• , Suresh B. Rangasamy
• , Sridevi Dasarathi
• , Avik Roy
• , Kalipada Pahan 

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Abstract

This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB) in converting poor learning mice to good learning ones. NaB, but not sodium formate, was found to upregulate plasticity-related molecules, stimulate NMDA- and AMPA-sensitive calcium influx and increase of spine density in cultured hippocampal neurons. NaB induced the activation of CREB in hippocampal neurons via protein kinase A (PKA), which was responsible for the upregulation of plasticity-related molecules. Finally, spatial memory consolidation-induced activation of CREB and expression of different plasticity-related molecules were less in the hippocampus of poor learning mice as compared to good learning ones. However, oral treatment of cinnamon and NaB increased spatial memory consolidation-induced activation of CREB and expression of plasticity-related molecules in the hippocampus of poor-learning mice and converted poor learners into good learners. These results describe a novel property of cinnamon in switching poor learners to good learners via stimulating hippocampal plasticity.