Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,805 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Thursday, June 6, 2019
E-cigarettes and CV risk: Current state of the evidence for cardiologists
So I guess I'll have to do patches for my nicotine needs post stroke.
I'm going to do the nicotine patches for my next stroke
even though I have no clue on dosage. Don't listen to me with no
medical training. Is your doctor trained in the latest research? Say the last 20 years?
Cardiology Today, June 2019 Olusola A. Orimoloye, MD, MPH; Mohammadhassan Mirbolouk, MD; Michael J. Blaha, MD, MPH
Electronic
cigarettes include a diverse group of battery-powered devices that
vaporize nicotine-containing, often flavored solvents for inhalation.
Initially, these devices were proposed as an alternative cessation
strategy for cigarette smokers who are unable to quit using conventional
cessation therapies.
However, since their introduction into the U.S. market in 2006,
e-cigarettes have gained popularity, especially among youth, and their
use (also called vaping) has considerably extended to “never smokers.”
In a recent study, it was estimated that as of 2016, almost 2 million
U.S. adults who had never smoked cigarettes were current users of these
products. With the recent introduction of newer brands (eg, Juul), which
can be used more discreetly among teenagers, evidence suggests that
e-cigarette use prevalence has trended upward, particularly in youth.
Olusola A. Orimoloye
In 2016, the FDA extended its regulatory authority to e-cigarettes
through the Deeming Rule. However, to guide further regulation of these
products in adults, the FDA requires actionable evidence on their health
effects, including any potential CV toxicity.
Mohammadhassan Mirbolouk
Vaping and cardiotoxicity
There are many constituent components of inhaled e-cigarette vapor that may be potential candidates for CV toxicity (Table).
These include toxic metals such as lead, nickel and chromium; volatile
organic compounds (VOCs) such as acrolein, flavoring derivatives; and
nicotine, a known trigger for myocardial ischemia and infarction due to
stimulation of the sympathetic nervous system. Comparative studies of
VOC exposure across a range of tobacco product use behaviors suggest
that sole e-cigarette users have significantly greater levels of
exposure to VOCs than nonusers of tobacco products, albeit lower than in
conventional cigarette smokers.
Michael J. Blaha
Given the popularity of e-cigarette use and the aforementioned
concerns about potential CV toxicity, there has therefore been
considerable interest in understanding CV risks that may attend the use
of these products, in absolute terms, and relative to conventional
cigarette smoking.
E-cigarettes and CV risk
Unfortunately, according to the 2018 report of the National Academies
of Sciences, Engineering, and Medicine, titled “Public Health
Consequences of Electronic Cigarette Use,” there is, as yet, no
available evidence as to whether e-cigarette use is associated with
clinical CV outcomes such as CHD, peripheral artery disease or stroke,
and subclinical disease, including carotid intima-media thickness and
coronary artery calcification.
Despite the general availability of laboratory-based animal studies,
and short-term exposure studies that have highlighted unfavorable
effects of e-cigarette exposure on short-term outcomes such as heart
rate variability, oxidative stress and endothelial dysfunction, critical
prospective epidemiologic data are sparse (Table).
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