Maybe something is some of these? WHOM do we ask to do followup research? Since there is NO STROKE LEADERSHIP nothing will occur.
Sabinsa’s curcuminoid improves cytokine levels in traumatic brain injury patients
July 2020
Candesartan could ameliorate the COVID-19 cytokine storm
August 2020
Spices in a high-saturated-fat, high-carbohydrate meal reduce postprandial proinflammatory cytokine secretion in men with overweight or obesity: A 3-period, crossover, randomized controlled trial March 2020
Cannabinoids, Blood–Brain Barrier, and Brain Disposition March 2020
In here is this line: Several findings indicate that CBD can modify the deleterious effects on BBB caused by inflammatory cytokines
Positive affect and markers of inflammation: Discrete positive emotions predict lower levels of inflammatory cytokines. May 2015
Researchers Discover New Way to Block Inflammation in Alzheimer’s, Atherosclerosis and Type-2 Diabetes July 2013
The latest here:
EXPRESS: Inflammatory cytokines, high sensitivity CRP, and risk of 1-year vascular events, death and poor functional outcome after stroke and TIA
Abstract
Background
Inflammation driven by pro-inflammatory cytokines is a new therapeutic target in coronary disease. Few data exist on the association of key upstream cytokines and post-stroke recurrence. In a prospective cohort study, we investigated the association between pivotal cytokines, CRP and 1-year outcomes.
Methods
BIO-STROKETIA is a multi-centre prospective cohort study of non-severe ischemic stroke (mRS≤3) and TIA. Controls were patients with transient symptoms attending TIA clinics with non-ischemic final diagnosis. Exclusion criteria were severe stroke, infection and other pro-inflammatory disease. High-sensitivity serum C-reactive protein (CRP) and cytokines (interleukin [IL] 6, IL-1β, IL-8, IL-10, IL-12, interferon-γ [IFN-γ], tumor-necrosis factor-α [TNF-α]) were measured. The primary outcome was 1-year recurrent stroke/coronary events (fatal and non-fatal).
Results
680 patients (439 stroke, 241 TIA) and 68 controls were included. IL-6, IL-1β, IL-8, IFN-γ, TNF-α, and CRP were higher in stroke/TIA cases (p≤0.01 for all). On multivariable Cox regression, IL-6, IL-8, and CRP independently predicted 1-year recurrent vascular events (adjusted HRs [aHR] per-quartile increase IL-6 1.31,CI 1.02-1.68, p=0.03; IL-8 1.47, CI 1.15-1.89, p=0.002; CRP 1.28 CI, 1.01-1.62, p=0.04). IL-6 (aHR 1.98, CI 1.26-3.14, p=0.003) and CRP (aHR 1.81, CI 1.20-2.74, p=0.005) independently predicted 1-year fatality. IL-6 and CRP (adjusted OR per-unit increase 1.02, CI 1.01-1.04) predicted poor functional outcome, with a trend for IL-1ï¢ (p=0.054).
Conclusion
Baseline
inflammatory cytokines independently predicted late recurrence,
supporting a rationale for randomised trials of anti-inflammatory agents
for prevention after stroke and suggesting that targeted therapy to
high-risk patients with high baseline inflammation may be beneficial.(How do we change may to will? With NO STROKE LEADERSHIP nothing will be done.)
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