Do we have ANY INNOVATIVE thinkers in stroke that will look at this and say;'
'Maybe this could work for stroke'! I bet we have shit for brains that can't think AND WILL DO NOTHING!
We already have these brain representatives:
- Brain on a chip
(9 posts to October 2012)
- brain organoid
(8 posts to May 2018)
- artificial brains
(4 posts to February 2015)
‘Dancing’ Molecules Spur Healing in Spinal Cord Tissue
Under a fluorescence microscope at Northwestern University, a sphere of human spinal cord tissue — about 3 mm across, roughly the diameter of a mouse spinal cord — erupted with green light. It had been stained with a calcium-sensitive dye that lights up living neurons and their extending fibers. This green light provided unmistakable visual proof of neurites streaming outward from the tissue’s injured surface and into a synthetic gel, where they were growing in organized, parallel structures.
That sphere of spinal cord tissue was a spinal cord organoid — a three-dimensional, miniaturized tissue model grown in a dish from human induced pluripotent stem cells (iPSCs) to recapitulate key features of an actual organ. This one had been differentiated over 24 weeks into a range of spinal cord cell types: neurons, astrocytes, oligodendrocyte progenitor cells, and Schwann cells.
The Northwestern team also incorporated microglia — the brain and spinal cord’s resident immune cells — by coaxing iPSC-derived progenitors to infiltrate the organoid. The result was an immune-competent model capable of mounting an inflammatory response to injury.
Then, to make the organoid useful, the team injured it — either slicing it with a scalpel to model surgical hemisection or crushing it with a mechanical impactor to deliver the kind of compressive contusion that causes most real-world spinal cord injuries.
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