Wednesday, May 27, 2015

Stroke Rounds: Novel Clot Buster Flops Again - desmoteplase

I guess vampire bat saliva doesn't work that well. I would argue that the Rankin scale used to evaluate effectiveness is totally inappropriate. If you want to do this objectively you run daily MRI scans to see if the size of the dead area increases less with interventions vs. placebo. Still to be tested;
1. liposome-encapsulated hemoglobin written in Feb. 2010
2. bat saliva - Draculin  written in May, 2011, up to 9 hours OK, maybe a no go
3. cardiac glycosides written in Feb. 2006 - up to 6 hours
4.inhalation of nitric oxide written in March, 2012 - 48 hours to 7 days
5. Nitric oxide written in 2006, to be tested in humans yet.
6. xenon gas written in Feb. 2006, to be tested yet
7. caffeinol irish coffee injection written in April 2003 to be tested in humans
8. Docosahexaenoic acid (DHA), a component of fish oil written in Nov. 2010, up to 5 hours
9. nicotine written in July 2005, to be tested in humans
10. Viagra written in 2002, to be tested in humans,  for 7 days
11.
11. Enzogenol  written in Nov. 2011 for New Zealand
12 edaravone approved in Japan since 2001
13. nitroglycerin instructions
14. benzodiazepine inverse agonist  written in Nov. 2010 

http://www.medpagetoday.com/Cardiology/Strokes/51760?xid=nl_mpt_DHE_2015-05-27&eun=g424561d0r

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