Brain Blood Flow Issues Linked to Mild Cognitive Impairment

 And I bet your competent? doctor DID NOTHING immediately post stroke to improve your cerebral blood flow and oxygen delivery to try and save those neurons about to die from the neuronal cascade of death in the first week.  

Maybe these, why isn't your incompetent doctor already delivering these to you?

cerebral blood flow (36 posts to July 2016)

oxygen delivery (31 posts to January 2020)

I'd suggest charging your doctor $1000 a neuron that died in the first week. 

Here are the calculations I put together:

My calculation is that my doctors let 

5.4 billion neurons die. 

21,600 miles dead myelinated fibers 

2.8 trillion dead synapses 

All in the first week!

Day 1: first 90 minutes:
171 million dead neurons 
1.260 trillion dead synapses
675 miles of dead myelinated fibers
Brain aged 5.4 years

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Days 2-3:
So 1440 minutes a day * 2days * 950000 = 2,736,000,000  or 2.7 billion  dead neurons
  1440 minutes a day *2days * 7,000,000,000syn = 20,160,000,000,000     20.2 trillion        dead synapses
1440 * 2days * 3.75mi = 10800 mi  dead myelinated fibers
Brain aged - 2 years, a guess
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Days 4-7:
So 1440 minutes a day * 4days * 475000 = 2,736,000,000  or 2.7 billion dead neurons
  1440 minutes a day *4days * 3,500,000,000syn = 20,160,000,000,000 20.2 trillion    dead synapses
1440 * 4days * 1.875mi = 10800 mi  dead myelinated fibers
Brain aged - 2 years, a guess 

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This is one hell of a lot of damage to recover from. Especially since we don't know how to move functions from dead locations to new ones.  Or know how to usefully get neurogenesis to work.

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Totals:
5.571 billion dead neurons
4.041260 trillion dead synapses
 22,275 miles dead myelinated fibers
Brain aged -  9.4 years

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The brain contains 80 billion neurons, I only lost 6.96375% of my brain.  
My charge would be $5.57100000E+15, whatever that is in real terms, beyond my calculators capacity. 

Damn hard to recover from all that with no stroke protocols.    

Brain Blood Flow Issues Linked to Mild Cognitive Impairment

Summary: Older adults with mild cognitive impairment (MCI) face higher cerebrovascular impedance, or resistance in brain blood flow, according to a new study. Researchers found this increased resistance leads to hypoperfusion, or reduced blood flow in the brain, which may contribute to cognitive difficulties in aging adults.

By using ultrasound and blood pressure tools, scientists analyzed brain blood flow in 58 older adults with MCI and 25 without, discovering a significant difference in cerebrovascular health between the two groups.

This finding suggests vascular function plays a vital role in maintaining cognitive health. The study opens new avenues for exploring interventions to improve blood flow and support cognitive function in older adults at risk of Alzheimer’s.

Key Facts

• Increased cerebrovascular impedance in MCI patients lowers brain blood flow.
• Hypoperfusion from blood flow resistance may worsen cognitive symptoms.
• The study suggests vascular health is crucial for cognitive function in aging.

Source: American Physiological Society

Older adults with mild cognitive impairment showed greater resistance to brain blood flow compared to those without cognitive impediments.

The first-of-its-kind study is published in the Journal of Applied Physiology and has been chosen as an APSselect article for October.  

The research team found the volunteers with mild cognitive impairment had higher cerebrovascular impedance and, in turn, decreased blood flow (hypoperfusion) through the brain. Credit: Neuroscience News

Brain blood flow resistance (also called cerebrovascular impedance) is linked to cognitive problems, which can manifest in several ways, including:

• Difficulty remembering recent events.
• Difficulty finding the right word or remembering a name.
• Difficulty focusing on a task.
• Disorientation in time and space. 

The purpose of the study was to determine if mild cognitive impairment affects the brain’s blood vessels’ ability to transport blood.

Using blood pressure instruments and ultrasonogram imaging to measure impedance in the brain’s blood vessels, the research team studied 58 older adults with mild cognitive impairment who have a higher risk for developing Alzheimer’s disease.

The researchers compared these participants to 25 age-matched volunteers with normal cognition.

The research team found the volunteers with mild cognitive impairment had higher cerebrovascular impedance and, in turn, decreased blood flow (hypoperfusion) through the brain.

Hypoperfusion can lead to cognitive problems in older adults.

“These findings shed light on the pathophysiological mechanisms of brain hypoperfusion in older adults who have a high risk of [Alzheimer’s disease],” the researchers wrote.

“This study highlights the importance of brain vascular function in brain health in older adults,” said Rong Zhang, PhD, a professor of neurology and senior author of the study.

About this cognition and aging research news

Author: Erica Roth
Source: American Physiological Society
Contact: Erica Roth – American Physiological Society
Image: The image is credited to Neuroscience News

Original Research: Open access.
“Patients with amnestic mild cognitive impairment have higher cerebrovascular impedance than cognitively normal older adults” by Rong Zhang et al. Journal of Applied Physiology