Ask your competent? doctor for EXACT PROTOCOLS on how to get synaptogenesis, dendritic branching and axon pathfinding done so you can recover from your stroke. Your doctor better know all about these and how to get the connections done!
Synaptogenesis is the formation of synapses between neurons in the nervous system.
Neuroplasticity-related effects of vitamin D relevant to its neuroprotective effects: A narrative review
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Introduction
The
mechanisms regulated by vitamin D are not limited to its involvement in
the regulation of bone metabolism and calcium homeostasis. Its role in
cell differentiation and immune system function has been extensively
studied. In addition, the role of vitamin D in brain development and
function has attracted particular interest in recent decades (Kesby et
al., 2011; Cui and Eyles, 2022). Evidence suggests that vitamin D is a
pleiotropic molecule capable of interacting directly with multiple
targets (Kouba et al., 2024), a property that may be related to its
effects on cell differentiation (Ko et al., 2004), neurotrophin
expression (Féron et al., 2005), intracellular calcium signaling (Brewer
et al., 2006), neurotransmitter release and synthesis (Kesby et al.,
2017), and anti-inflammatory and antioxidant pathways (McCann and Ames,
2008; Cui et al., 2019). Therefore, hypovitaminosis D impairs the
expression of several molecular targets involved in these cellular
events (DeLuca et al., 2013; Kouba et al., 2022).
The
prominent role of vitamin D in central nervous system (CNS) homeostasis
suggests that deficiency of this vitamin may also be associated with a
variety of brain disorders. Indeed, studies have reported an association
between hypovitaminosis D and an increased risk of Azheimer's disease
(Annweiler et al., 2013), Parkinson's disease (Ogura et al., 2021), and
major depressive disorder (MDD) (Parker et al., 2017) in adults. In
addition, vitamin D has been shown to improve the symptoms and
behavioral changes associated with these disorders and may be used as a
therapeutic adjuvant and/or potential neuroprotective agent (Kouba et
al., 2022, Kouba et al., 2023b; Pignolo et al., 2022). Given that
Parkinson's disease, Alzheimer's disease, and MDD are associated with
impairment of neurogenic and synaptogenic processes (Skaper et al.,
2017; Levy et al., 2018; Zhang and Lu, 2021), this narrative review aims
to highlight neuroplasticity-related mechanisms of vitamin D that may
be associated with its neuroprotective effects.(What are the amounts?)
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