Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, July 4, 2019

Venturi Mask Adjuvant Oxygen Therapy in Severe Acute Ischemic Stroke

From May 2006 so you can see if your incompetent hospital did any followup or is doing testing on their own with this Venturi mask or nasal cannula. 

Venturi Mask Adjuvant Oxygen Therapy in Severe Acute Ischemic Stroke

Arch Neurol. 2006;63(5):741-744. doi:10.1001/archneur.63.5.741
Abstract
Background  The effect of oxygen therapy in acute ischemic stroke remains undetermined.
Objective  To investigate the feasibility of eubaric hyperoxia therapy by Venturi mask (VM) in a group of patients who experienced a severe acute ischemic stroke.
Design  Patients experiencing a first-ever large middle cerebral artery infarction were recruited within 48 hours after stroke. Patients were subdivided to undergo therapy with a VM with a fraction of inspired oxygen of 40% or with a nasal cannula. A large middle cerebral artery infarction was defined as a large low-attenuation area of more than one third of the middle cerebral artery territory on brain images. Stroke severity was evaluated by the National Institutes of Health Stroke Scale.
Results  Seventeen patients were enrolled in the VM group and 29 in the nasal cannula group. All the demographic and clinical characteristics were equally distributed initially. The mean initial National Institutes of Health Stroke Scale score was 20.5 and 18.9 in the VM and nasal cannula groups, respectively. Atrial fibrillation was found in 11 (65%) patients in the VM and 17 (59%) patients in the nasal cannula groups. The VM therapy was initiated within 13.7 (range, 3.0-41.5) hours after stroke and the duration was 132.9 (range, 48.0-168.5) hours. In-hospital mortality was 1 (6%) in the VM group and 7 (24%) in the nasal cannula group (P=.12). In the VM group, there were fewer incidences of fever (4 [24%] vs 15 [52%]; P=.06), pneumonia (1 [6%] vs 6 [21%]; P=.18), and respiratory failure (3 [18%] vs 8 [28%]; P=.45), but a higher incidence of bedsores (3 [18%] vs 2 [7%]; P=.29).
Conclusions  By using VM therapy with a fraction of inspired oxygen of 40%, there might be less mortality and comorbidities in treated patients who experienced a severe acute ischemic stroke. Further randomized confirmatory studies should explore the decreased mortality in patients who experience a severe acute ischemic stroke, especially in those with a large middle cerebral artery infarction who undergo VM therapy with a fraction of inspired oxygen of 40%.
After stroke, supplemental oxygen is advised if there is evidence of hypoxia. However, data are lacking to support general use of supplemental oxygen in patients who experience an acute ischemic stroke. Hyperbaric oxygen (HBO) therapy has been studied for decades in patients who experience an acute ischemic stroke. The potential benefit of HBO might include increased oxygen delivery, decreased cerebral edema, and decreased lipid peroxidation.1 But the effectiveness of HBO therapy in humans is undetermined.2
Other than HBO therapy, eubaric (normobaric) hyperoxia treatment after acute stroke has been investigated recently. Eubaric hyperoxia treatment significantly increased penumbral PO2 during ischemia and increased penumbral PO2 during reperfusion.3 Experimental studies revealed that eubaric hyperoxia might protect the cerebral cortex4 and improve the neuropathological outcome.5 However, 1 atm of 100% oxygen for the first 24 hours was not recommended for nonhypoxic patients who experienced minor or moderate strokes.6
Compared with HBO therapy, eubaric hyperoxia can be applied with a Venturi mask (VM) (Figure 1), which is a simple and readily available device.7 The device delivered the most precise inspired oxygen fraction. Thus, we sought to investigate the feasibility and explore the therapeutic effects of eubaric hyperoxia by using a VM in a group of patients with a large middle cerebral artery (MCA) infarction, aiming to generate a hypothesis for future randomized trials.
Methods
This study involved 46 consecutive patients who experienced a first-ever severe ischemic stroke and were admitted within 48 hours after stroke onset at Changhua Christian Hospital between January 1, 2000, and July 31, 2001. Patients were subdivided into 2 groups: 17 received supplemental oxygen therapy by a VM with a fraction of inspired oxygen of 40% and 29 declined to participate in the program but agreed to participate as control subjects by using a nasal cannula, 2 L/min. The inclusion criteria were as follows: (1) first-ever ischemic stroke, (2) infarction in the MCA territory presenting less than 48 hours after onset, (3) National Institutes of Health Stroke Scale score of 12, (4) modified Rankin Scale score no less than 4, and (5) brain computed tomographic images suggesting that the infarction area was more than one third of the MCA territory. The exclusion criteria were as follows: (1) any known respiratory distress before registry period noted, such as obstructive pulmonary disease and obstructive sleep apnea; (2) rapidly improving neurological deficits; (3) brain images that did not reveal the infarction area was more than one third of the MCA territory; (4) medically unstable, due to previously known endocrinological dysfunctions, hematological abnormalities, autoimmune diseases, or malignancies; (5) pregnancy; (6) seizure at onset of stroke; (7) received thrombolytic therapy within 3 months; and (8) inability to obtain informed consent.
The oxygen devices would be changed or their use discontinued when the patients began ventilation; also, there was no need for supplemental oxygen, which was left at the discretion of the investigators. Stroke severity was assessed by the National Institutes of Health Stroke Scale.
There were no restrictions to concomitant treatments, such as an intravenous infusion of isotonic sodium chloride solution, hyperosmotic agents, and oral antiplatelet drugs. Patients who underwent craniectomy would not be included in this study. All fever episodes had been treated with empirical antibiotics.
Stroke subtypes were classified according to the Oxfordshire Community Stroke Project criteria.8 The specific factors at baseline were defined as in the Copenhagen Stroke Study.9 We compared the baseline characteristics and the outcomes, including survival and hospital length of stay (LOS) by Pearson χ2 or Fisher exact test if applicable. All values were reported as median (range) or mean (standard deviation), and tests were 2-tailed and differences considered to be statistically significant at P<.05. Data were analyzed using a commercially available software program (SPSS version 10.0 for Windows; SPSS Inc, Chicago, Ill).
Results
Among 1013 consecutive patients who experienced a stroke and were admitted over a period of 18 months, 103 had a large MCA infarction. Only 46 of these patients with a large MCA infarction who had a first-ever ischemic stroke and were admitted within 48 hours after stroke onset were recruited into the analysis. The mean age of the patients was 79 years (median, 81 years; range, 49-93 years). Demographic characteristics are shown in Table 1. Atrial fibrillation (AF) was found in 28 (61%) of the 46 patients. There were no baseline differences between the 2 groups, except a slightly higher diastolic blood pressure in the nasal cannula group. The mean initial National Institutes of Health Stroke Scale score was 21 in the VM group and 18 in the nasal cannula group.
The VM therapy was initiated within 13.7 hours after stroke onset (median, 13 hours; range, 3.0-41.5 hours). The duration of VM use was 132.9 hours (median, 96 hours; range, 48.0-168.5 hours). All complications and vital status are shown in Table 2.
The mortality of the VM and nasal cannula groups was 1 (6%) and 7 (24%) (this percentage is different from the percentages totaled in the figure because of rounding) (P=.12) (Figure 2). One patient in the VM group died 4 days after stroke onset. Seven patients in the nasal cannula group died within 1 week after stroke.
The incidence of pneumonia was 1 (6%) in the VM group vs 6 (21%) in the nasal cannula group. There were fever episodes in 4 (24%) patients in the VM group and 15 (52%) patients in the nasal cannula group (P=.06). Asymptomatic petechial hemorrhages were seen in 2 patients in the VM group.
The overall LOS was 17 days (median, 13 days; range, 3-65 days): 17.2 days (median, 13 days; range, 4-58 days) in the VM group and 21.1 days (median, 13 days; range, 3-65 days) in the nasal cannula group. In patients with the total anterior circulation infarction subtype, the LOS was 17.9 days in the VM group vs 28.1 days in the nasal cannula group. Among the 11 patients with AF in the VM group, there was 1 death among those with the total anterior circulation infarction subtype and 0 deaths among those with the partial anterior circulation infarction subtype. Among the 17 patients with AF in the nasal cannula group, there were 5 deaths among those with the total anterior circulation infarction subtype and 1 death among those with the partial anterior circulation infarction subtype.

More at link. 

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