Deans' stroke musings: LONG-TERM OR SHORT-TERM CORTICOSTERONE TREATMENT SUPPRESSES ADULT HIPPOCAMPAL NEUROGENESIS LEADING TO ANXIETY-LIKE BEHAVIORS AND COGNITIVE DEFICITS BY ACTIVATING AUTOPHAGY AND DEPLETING BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, September 3, 2025

LONG-TERM OR SHORT-TERM CORTICOSTERONE TREATMENT SUPPRESSES ADULT HIPPOCAMPAL NEUROGENESIS LEADING TO ANXIETY-LIKE BEHAVIORS AND COGNITIVE DEFICITS BY ACTIVATING AUTOPHAGY AND DEPLETING BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)

Make sure your doctor understands your need for BDNF in your recovery. NO knowledge is GROUNDS FOR IMMEDIATE FIRING!

BDNF (184 posts to April 2011)

"CORT treatment" can refer to different medical treatments, including corticosteroid medications (like prednisone or cortisone shots) for anti-inflammatory and immunosuppressive effects,

LONG-TERM OR SHORT-TERM CORTICOSTERONE TREATMENT SUPPRESSES ADULT HIPPOCAMPAL NEUROGENESIS LEADING TO ANXIETY-LIKE BEHAVIORS AND COGNITIVE DEFICITS BY ACTIVATING AUTOPHAGY AND DEPLETING BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)

Type: article in the journal - scientific article Language: not defined

Volume: 78Number: 1 year: 2025

Pages: 95-102

Published: 10.01.2025

JOURNAL:
	THEORETICAL AND NATURAL SCIENCE Founders: Eliwise Academy Ltd ISSN: 2753-8818eISSN: 2753-8826

ANNOTATION:

Autophagy is regarded as a self-protective procedure of cells, however, it can also cause the death of cells under certain conditions and thereby cause the death of neural stem cels and lead to cognitive deficits. Previous studies hold different opinions of the way autophagy leads to cognitive deficits. One opinion is that corticosterone directly (CORT) directly surpasses AHN and lead to anxiety-like behaviors and cognitive deficits, another opinion is that CORT treatment causes the depleting of BDNF, and thereby lead to anxiety-like behavior and cognitive deficits. In our study, we conducted several behavioral tests on mice with short-term and long-term corticosterone treatment to determine the reason of the death of neural stem cells, in both short-term and long-term corticosterone treatments, the mice are injected with corticosterone, AAV, and BrdU regularly, and our conclusion is that in short-term treatment, it is the decline of BDNF that cause cell death, while in long-term treatment, both the decline of BDNF and autophagy itself contribute to cell death..