Deans' stroke musings: Neurodegeneration After Stroke: Is the Grass Really Greener on the Other Side?

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, March 4, 2022

Neurodegeneration After Stroke: Is the Grass Really Greener on the Other Side?

How EXACTLY is this research going to be used to prevent dementia? No answer, then this was useless research.

https://doi.org/10.1016/j.apmr.2022.01.055 Get rights and content

Research Objectives

The purpose of this project was to use magnetic resonance imaging of the brain and determine how the size and location of a stroke can affect neurodegeneration on the non-lesioned side of the brain. In hypothesis, we believe that both hemispheres will experience neurodegeneration but there will be a significantly higher amount of neurodegeneration in the lesioned side.

Design

T1-weighted magnetic resonance imaging and diffusion weighted imaging (DWI) of the brain was collected in 23 patients with chronic stroke and 14 healthy controls. We quantified the amount of neurodegeneration in the lesioned and non-lesioned hemisphere in the cerebral peduncles (CP) and the posterior limb of the internal capsule (PLIC). The size and the white matter integrity in the region of interest were determined. The amount of neurodegeneration between groups was statistically compared, a p<0.05 was considered statistically significant.

Setting

General Community.

Participants

Random selection of stroke patients and healthy controls.

Interventions

Not applicable.

Main Outcome Measures

Fractional anisotropy (FA) of the brain, upper extremity fugyl-meyer score.

Results

We observed that CPs in the lesioned hemisphere were smaller compared to the non-lesioned hemisphere and healthy controls (304mm3 vs 488 mm3 vs 374 mm3). In addition, patients with stroke had reduced white matter integrity in both the lesioned (255.99±35.43) and non-lesioned (257.36 ± 39.21) hemispheres compared to controls (329.98 ± 23.45). Thus, both sides of the brain experience neurodegeneration after a stroke.

Conclusions

Our results indicated that the stroke caused neurodegeneration on both sides of the brain with damage being significantly higher in the lesioned side. This suggests that therapists should consider targeting both sides of the body rather than just the more affected limb.