Deans' stroke musings: Trigger Factors In Patients With A Patent Foramen Ovale Associated Stroke: A Case-Crossover Study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, March 19, 2024

Trigger Factors In Patients With A Patent Foramen Ovale Associated Stroke: A Case-Crossover Study

So you'll want your competent? doctor to not have any of these triggers go off if you have a PFO!

Meaning:

Vaccines for flu, pneumonia, RSV, COVID-19.
No high intensity exercise of any sort.

Trigger Factors In Patients With A Patent Foramen Ovale Associated Stroke: A Case-Crossover Study

Maikel Immens https://orcid.org/0000-0003-3359-4645, Merel Sanne Ekker https://orcid.org/0000-0001-6598-2218, and Frank-Erik de Leeuw FrankErik.deleeuw@radboudumc.nlView all authors and affiliations

Accepted Manuscripts

https://doi.org/10.1177/17474930241242625

Abstract

Background:

Patent foramen ovale (PFO) is a congenital anatomical variant which is associated with strokes in young adults. Contrary to vascular risk factors and atherosclerosis, a PFO is present from birth. However, it is completely unknown how an anatomical structure that is already present at birth in a large proportion of the population, can convert into a PFO that causes stroke in a few. Recent studies reported a significant association between certain trigger factors and ischemic stroke in young adults. This study aims to investigate these triggers in PFO-associated stroke.

Methods:

The ODYSSEY Study, a multicenter prospective cohort study between 2013 and 2021, included patients aged 18-49 years experiencing their first-ever ischemic event. Participants completed a questionnaire about exposure to potential trigger factors. A case-crossover design was used to assess the relative risks (RR) with 95% confidence intervals (95% CI). The primary outcome was the relative risk of potential trigger factors for PFO-associated stroke.

Results:

1043 patients completed the questionnaire and had an ischemic stroke of which 124 patients had a PFO-associated stroke (median age 42.1 years, 45.2% men). For patients with PFO-associated stroke the RR was 26.0 (95% CI 8.0-128.2) for fever, 24.2 (95% CI 8.5-68.7) for flu-like disease and RR 3.31 (95% CI 2.2-5.1) for vigorous exercise.