Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 20, 2024

Use It and Improve It or Lose It: Interactions between Arm Function and Use in Humans Post-stroke

  I absolutely hate these pontifications on nonuse. Solve the damn problem of dead brain rehab and this nonuse problem goes away. SOLVE THE CORRECT PROBLEM!

Damn it all, it is NOT learned nonuse. It is the actual inability to use it because of dead neurons. If you had dead brain rehab protocols, this fake learned nonuse idea would cease to exist!

 

Use It and Improve It or Lose It: Interactions between Arm Function and Use in Humans Post-stroke

Yukikazu Hidaka 1 , Cheol E. Han 1,2 , Steven L. Wolf 3 , Carolee J. Winstein 4 , Nicolas Schweighofer 4 * 1 Computer Science, University of Southern California, Los Angeles, California, United States of America, 2 Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea, 3 Department of Rehabilitation Medicine, Emory University, Atlanta, Georgia, United States of America, 4 Biokinesiology, University of Southern California, Los Angeles, California, United States of America  

Abstract  

‘‘Use it and improve it, or lose it’’ is one of the axioms of motor therapy after stroke. There is, however, little understanding of the interactions between arm function and use in humans post-stroke. Here, we explored putative non-linear interactions between upper extremity function and use by developing a first-order dynamical model of stroke recovery with longitudinal data from participants receiving constraint induced movement therapy (CIMT) in the EXCITE clinical trial. Using a Bayesian regression framework, we systematically compared this model with competitive models that included, or not, interactions between function and use. Model comparisons showed that the model with the predicted interactions between arm function and use was the best fitting model. Furthermore, by comparing the model parameters before and after CIMT intervention in participants receiving the intervention one year after randomization, we found that therapy increased the parameter that controls the effect of arm function on arm use. Increase in this parameter, which can be thought of as the confidence to use the arm for a given level of function, lead to increase in spontaneous use after therapy compared to before therapy. Citation: Hidaka Y, Han CE, Wolf SL, Winstein CJ, Schweighofer N (2012) Use It and Improve It or Lose It: Interactions between Arm Function and Use in Humans Post-stroke. PLoS Comput Biol 8(2): e1002343. doi:10.1371/journal.pcbi.1002343 Editor: Jo ¨ rn Diedrichsen, University College London, United Kingdom Received October 4, 2010; Accepted November 21, 2011; Published February 16, 2012 Copyright: ß 2012 Hidaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was funded in part by grant NIH RO3 HD050591-02, R01 HD065438, and R01 HD 37606 and by the National Research Foundation of Korea, Ministry of Education, Science and Technology (R32-10142). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: schweigh@usc.edu

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