Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, October 2, 2024

Research Progress on Brain-Derived Neurotrophic Factor (BDNF) in the Sequelae of Stroke

Well, where are the exact protocols that will deliver the BDNF needed for stroke recovery? Aren't your mentors and senior researchers even trying to solve stroke? Or is that too fucking difficult?  Hope you don't have too much difficulty getting to 100% recovery when you are the 1 in 4 per WHO that has a stroke!

Just maybe you want to start solving stroke NOW!

Here for your edification is lots of research on BDNF. I'm sure there's a hell of a lot more, I've only been doing this for 14 years.

  • BDNF (177 posts to April 2011)

 


 Research Progress on Brain-Derived Neurotrophic Factor (BDNF) in the Sequelae of Stroke

Abstract

The research progress of brain-derived neurotrophic factor (BDNF) in the treatment of sequelae of stroke is an important topic

(YES, BUT WHY THE HELL AREN'T YOU SOLVING IT? NOT MY JOB? NOT MY PROBLEM?) Stroke is among the diseases with the highest mortality and disability rates among the elderly in China. BDNF plays an important role in the development and functional maintenance of the nervous system. In recent years, the application value of BDNF in rehabilitation therapy has gradually received attention. This study has adopted a systematic literature review method, searched Chinese and English databases, screened relevant studies, and conducted data extraction and quality evaluation. This review systematically introduced the research progress of BDNF in the correlation with post-stroke sequelae, with special attention to its application in post-stroke depression, motor dysfunction, and cognitive dysfunction. The results showed that a decrease in BDNF levels is closely related to the exacerbation of depressive symptoms, limited recovery of motor dysfunction, and the occurrence of cognitive dysfunction. BDNF, as a key neurobiological factor, has shown significant potential in the rehabilitation treatment of stroke. By exploring the potential of BDNF as a therapeutic target to prevent and treat sequelae of ischemic stroke, the current research bottlenecks, and the development trends of future treatment strategies.
Xie, F. , Chen, W. and Huang, L. (2024) Research Progress on Brain-Derived Neurotrophic Factor (BDNF) in the Sequelae of Stroke. Journal of Biosciences and Medicines, 12, 196-203. doi: 10.4236/jbm.2024.129019.

1. Introduction

Stroke is one of the leading causes of death and disability among adults in China. With the aging of the population in China, the incidence rate of stroke is on the rise. According to the epidemiological survey, the incidence rate of stroke in China is higher than the global average, which brings a huge burden to the social and public health system [1]. Stroke is mainly divided into two categories: ischemic stroke and hemorrhagic stroke. Among them, ischemic stroke accounts for about 80% of all strokes [2]. The best period for rehabilitation is within 3 to 6 months after stroke, and implementing rehabilitation can reduce the conversion of ischemic stroke disability to disability [3]. Modern rehabilitation theory and practice have proven that effective rehabilitation training can alleviate patients’ functional disabilities [4]. Brain-derived neurotrophic factor (BDNF) is a key neurotransmitter that plays a crucial role in the development and functional maintenance of the nervous system. In recent years, with the deepening of research on BDNF, its application value in the rehabilitation of therapy has gradually received attention. This article aims to review the application progress of BDNF in the rehabilitation treatment of post-stroke sequelae and propose future research directions.

More at link.

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