Deans' stroke musings: Immune Resilience Identified as Key to Healthy Aging and Longevity

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, April 24, 2025

Immune Resilience Identified as Key to Healthy Aging and Longevity

You want healthy aging so DEMAND YOUR DOCTOR DO SOMETHING ABOUT IT!

Immune Resilience Identified as Key to Healthy Aging and Longevity

Summary: A new study reveals that immune resilience, a person’s ability to maintain a robust, youthful immune system, plays a critical role in promoting long-term health and extending life. By analyzing data from over 17,000 individuals, researchers found that immune resilience, particularly involving the TCF7 gene, protects against chronic inflammation, immunosenescence, and cell death.

Individuals in midlife with high immune resilience had a 69% lower mortality rate and a biological age advantage of up to 15 years. These findings spotlight immune resilience as a central factor in sustaining health and suggest that midlife is the optimal window for interventions to extend healthspan.

Key Facts:

Protective Power: Immune resilience reduces midlife mortality risk by 69%.
Longevity Marker: TCF7 gene helps preserve immune cell regeneration and function.
15-Year Gap: Poor immune resilience at 40 equals the mortality risk of someone aged 55.5.

Source: Wiley

A study published in Aging Cell has identified immune resilience as a key driver of salutogenesis—the active process of promoting health and well-being.

By analyzing data from 17,500 individuals across various life stages, investigators uncovered the importance of immune resilience involving TCF7, a gene essential for maintaining immune cell regenerative potential, in fostering healthy aging and longevity.

This shows two older ladies and DNA. — Maintaining optimal immune resilience preserves youthful immune profiles at any age; enhances vaccine responses; and significantly reduces the burden of cardiovascular disease, Alzheimer’s disease, and severe infections. Credit: Neuroscience News

The research indicates that immune resilience counters three major factors of aging and mortality: chronic inflammation, immune system decline(immunosenescence), and cell death.

This protective mechanism mitigates biological aging processes and confers survival advantages.

For example, at age 40, individuals with poor immune resilience face a 9.7-fold higher mortality risk—a risk equivalent to that of 55.5-year-olds with optimal immune resilience, resulting in a 15.5-year survival gap.

Maintaining optimal immune resilience preserves youthful immune profiles at any age; enhances vaccine responses; and significantly reduces the burden of cardiovascular disease, Alzheimer’s disease, and severe infections.

Midlife (ages 40–70) emerges as a pivotal window for longevity, with immune resilience reducing mortality by 69% during this period.

However, after age 70, mortality rates converge between resilient and non-resilient groups, suggesting biological limits on lifespan extension.

These findings underscore the importance of early midlife interventions to boost immune resilience to maximize healthspan.

“While most aging research focuses on disease mechanisms and the biology of aging, our work highlights how immune resilience sustains salutogenesis—actively promoting health,” said senior author Sunil K. Ahuja, MD, of UT Health San Antonio and the South Texas Veterans Health Care System. “This opens new avenues for strategies to enhance lifelong wellness.”