Many stroke patients with carotid artery narrowing may avoid surgery, research shows

 

 I still don't understand why you would medically need to stent a carotid artery or do an endarterectomy at all if the Circle of Willis is complete. (Unless the whole point is revenue and profit generation) It would seem to make more sense to just close it up and prevent problems from there.  My right carotid artery was closed for 10 years and I cognitively functioned quite well with no episodes of fainting.

Didn't your competent? doctor tell you of these possible complications of endarterectomy? NO? So, your doctor isn't competent?

Possible problems:

Cognitive Dysfunction and Mortality After Carotid Endarterectomy

Carotid Interventions for Women: The Hazards and Benefits

Female Gender Increases Risk of Stroke and Readmission after CEA(Carotid endarterectomy) and CAS(carotid artery stenting)

Ticagrelor Induced Angioedema Following Carotid Artery Stenting

Cognitive Dysfunction and Mortality After Carotid Endarterectomy

Here is why your doctor needs to GUARANTEE NO complications from stenting!

• stenting (22 posts to May 2011)

• carotid stenting (21 posts to May 2016)

• carotid artery stenting (7 posts to November 2021)

Many stroke patients with carotid artery narrowing may avoid surgery, research shows

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 Reviewed

Amsterdam University Medical CenterApr 16 2025

European research led by University College London (UCL), together with Amsterdam UMC and the University of Basel shows that a significant proportion of patients who suffer a stroke due to carotid artery narrowing can be treated with medication only. A risky carotid artery operation, currently still the standard treatment for many patients, may then no longer be necessary for this group of patients. This research, published today in the Lancet Neurology, may lead to the global guidelines for the treatment of these patients being adjusted.

In the Netherlands, about 2,000 people with carotid artery stenosis are operated on every year after they have had a stroke. 30 years ago, large studies showed that an operation, in which a narrowing in the carotid artery is removed, reduced the risk of a new stroke. As a result, this became the international standardised treatment. Since then, the medications these patients receive alongside their surgery – such as blood thinners, medication for cholesterol and high blood pressure – have improved significantly. Researchers, including Amsterdam UMC neurologist Paul Nederkoorn, investigated whether routine carotid artery operations are still necessary in all patients. An international research group of neurologists, vascular surgeons, and radiologists together designed the ECST study to answer this question.

For the vast majority of these patients, in the Netherlands perhaps up to about 75 percent, medication alone is probably sufficient to reduce the risk of another stroke. It is a lot nicer for the patient not to have to have surgery and it saves a lot of healthcare costs. We are now going to work closely with the vascular surgeons to see how we can best fit these results into the current protocols."

Paul Nederkoorn, Amsterdam UMC neurologist

Following patients for two years

Between 2012 and 2019, the researchers examined a group of 429 patients, spread over 30 centers in Europe and Canada. All patients had a low or average chance of having another stroke within 2 years of their initial treatment. Patients with a high risk of another stroke were not included in this study, because it was uncertain beforehand whether medication alone could be equally effective for them.

Patients were divided into two groups. Half received only medication, and the other half also received standard surgery. Two years after the start of their treatment, the patients were monitored for a number of outcomes. The groups were compared on the basis of how often new strokes had occurred, how many patients had had a heart attack and in how many cases patients had had a stroke unnoticed or where there was a high risk of a new stroke due to accumulations in the carotid artery. This could be seen on the MRI scans that the participating patients received after 2 years. The two groups scored equally across all metrics, leading the researchers to conclude that the operation is not necessary for this specific patient group in addition to medication.

Senior author, Emeritus Professor at UCL Martin Brown, said: "While further follow-up and additional trials are needed to confirm these findings, we recommend using the CAR score to identify patients with carotid narrowing who can be managed with optimised medical therapy alone.

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"This approach emphasises personal assessment and intensive treatment of vascular risk factors, potentially sparing many patients from the discomfort and risks of carotid surgery or stenting.

"Additionally, this method could lead to substantial cost savings for health services."

Adjusting international guidelines

Follow-up research should show which patients have such a high risk of another stroke that they still do need surgery in addition to the medication. New techniques for detailed imaging of the atherosclerotic plaque in the carotid artery allow for the selection of particularly high-risk patients much more accurately than before. The researchers think that in the future this will be the group that may still have to undergo surgery. In this way, every patient with a stroke due to carotid artery narrowing can receive a tailor-made risk-based treatment. That saves many patients a major operation and lowers healthcare costs. The researchers expect that the national and international guidelines will soon be adjusted.

"At Amsterdam UMC, we are working together with the vascular surgeons and those low- and medium-risk patients are no longer operated on as standard," concludes Nederkoorn

Source:

Amsterdam University Medical Center

Journal reference:

Donners, S. J. A., et al. (2025). Optimised medical therapy alone versus optimised medical therapy plus revascularisation for asymptomatic or low-to-intermediate risk symptomatic carotid stenosis (ECST-2): 2-year interim results of a multicentre randomised trial. The Lancet Neurology. doi.org/10.1016/S1474-4422(25)00107-3.