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CBD Calms the Inflamed Alzheimer’s Brain
Summary: A new study reveals that cannabidiol (CBD) can significantly reduce neuroinflammation associated with Alzheimer’s disease. In experiments using an Alzheimer’s mouse model, researchers found that inhaled CBD lowered the activity of key genes driving inflammation and decreased harmful proinflammatory molecules in the brain.
The compound interacted with specific immune regulators that control the body’s inflammatory response, suggesting a multitarget therapeutic potential. These findings indicate CBD may not only soothe chronic brain inflammation but also complement plaque-clearing strategies for a broader Alzheimer’s treatment approach.
Key Facts:
- Neuroinflammation Control: CBD reduced activation of immune pathways driving inflammation in Alzheimer’s mice.
- Multitarget Mechanism: CBD interacted with distinct regulators of neuroinflammation and immune balance.
- Therapeutic Promise: The findings suggest CBD could help both calm immune overactivity and aid in plaque clearance.
Source: SfN
Neuroinflammation damages neurons and can contribute to diseases like Alzheimer’s. Cannabidiol (CBD) has anti-inflammatory properties, which suggests that it could combat neuroinflammation in Alzheimer’s.
In a new eNeuro paper, Babak Baban and colleagues, from Augusta University, explored whether CBD can be leveraged as an anti-inflammatory treatment in an established Alzheimer’s disease mouse model.
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| Baban et al. also identified distinct regulators of the immune response and neuroinflammation with which CBD interacted. Credit: Neuroscience News |
The researchers assessed two distinct mechanisms for shaping immune responses and regulating neuroinflammation in the central nervous system following CBD treatment via inhalation.
With several molecular and genetic measures, they discovered that CBD reduced expression of key regulators for neuroinflammation in Alzheimer’s mice, which was associated with less proinflammatory molecules.
Baban et al. also identified distinct regulators of the immune response and neuroinflammation with which CBD interacted.
“Alzheimer’s work has long centered on plaques and tangles,” says Baban.
“But our study shows that chronic autoinflammation is also a core driver of the disease. What’s exciting is that CBD not only calms this immune overactivation but, in earlier work, we’ve shown it can also help clear plaques and tangles through a different mechanism.
“Together, this points to a multitarget approach with real therapeutic potential.”
Key Questions Answered:
A: CBD reduces neuroinflammation by lowering expression of genes involved in immune overactivation.
A: They found that CBD interacts with specific immune regulators and decreases proinflammatory molecules in the brain.
A: It offers a potential dual-action therapy that addresses both inflammation and plaque buildup, two key drivers of Alzheimer’s pathology.
About this neuropharmacology and Alzheimer’s disease research news
Author: SfN Media
Source: SfN
Contact: SfN Media – SfN
Image: The image is credited to Neuroscience News
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