Your competent? doctor created EXACT PROTOCOLS on the gut-brain axis almost a decade ago, right? Oh no, you have a fucking INCOMPETENT DOCTOR THAT DID NOTHING, RIGHT!
And let's see how long your doctor has been incompetent on the gut-brain axis, only 9 years!
I'd fire you all for incompetence!
The Gut–Brain Axis in Neurodegeneration and Neural Repair: Microbiome-Driven Modulation of CNS Inflammation, Neurogenesis, and Recovery
Oluwaseye Emmanuel Olayemi1, Olusoji Oyesola2, Babatunde Okebule3,
Zainob Sobowale4 and Elizabeth Anthony5
1,2,3,4 Olabisi Onabanjo University, Faculty of Basic Medical Sciences, Department of
Physiology, Ago-Iwoye, Nigeria.
5 Olabisi Onabanjo University, Faculty of Basic Medical Sciences, Department of
Anatomy, Ago-Iwoye, Nigeria.
Emails: olayemi.oluwaseye@oouagoiwoye.edu.ng, olusoji.oyesola@oouagoiwoye.edu.ng,
okebule.babatunde@oouagoiwoye.edu.ng, zainoboluwaferanmis@gmail.com,
anthonyelizabeth999@gmail.com
Received on, 20 July 2025 - Accepted on, 07 September 2025 - Published on, 16 September 2025
ABSTRACT:
Background:
The gut–brain axis represents a
dynamic, bidirectional communication network
linking the gastrointestinal microbiota with central
nervous system (CNS) function. Emerging research
implicates gut dysbiosis in the progression of
neurodegenerative disorders such as Alzheimer’s
disease (AD) and Parkinson’s disease (PD), as well
as in the regulation of neuroinflammatory tone and
adult neurogenesis. Understanding the microbial
regulation of CNS integrity offers a novel vantage
point for both neuropathology and recovery.
Methodology:
This review synthesizes findings from recent preclinical and clinical studies that explore the mechanistic underpinnings of the gut–brain axis in neurodegeneration and neural repair. Emphasis is placed on germ-free models, microbiome sequencing in human cohorts, and interventional trials involving probiotics, dietary strategies, and fecal microbiota transplantation (FMT). axis, microbiota, neurogenesis, neurodegeneration, short-chain fatty acids.
Conclusion:
The gut–brain axis is a critical
modulator of CNS health, with disruptions
contributing to neurodegeneration and offering a
therapeutic window for repair. Future work should
address causality, interindividual variability, and
ethical considerations of microbiome manipulation
to enable precision interventions targeting brain
resilience and regeneration.
Results:
Microbiota-derived metabolites
such as short-chain fatty acids (SCFAs) and
tryptophan catabolites influence neuroimmune
responses, blood–brain barrier (BBB) integrity,
and neurogenesis in the hippocampus and
subventricular zone. Dysbiosis is associated
with heightened microglial activation, impaired
Aβ clearance, and α-synuclein aggregation.
Conversely, modulation of the microbiota through
probiotics or dietary interventions can attenuate
neuroinflammation and improve cognitive and
motor outcomes in both animal models and early stage clinical trials.
No comments:
Post a Comment