Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, January 5, 2012

Vitamin D: Too Much May Erase Heart Benefit

Two earlier posts on Vitamin D are here; read them all and talk to your doctor.
http://oc1dean.blogspot.com/2011/12/vitamin-d-fails-again-to-affect-cv.html
http://oc1dean.blogspot.com/2011/11/excessive-amounts-of-vitamin-d-linked.html
The latest one here:
http://www.medpagetoday.com/Cardiology/Prevention/30514?utm_source=cardiodaily&utm_medium=email&utm_content=aha&utm_campaign=01-05-12&eun=gd3r&userid=424561&email=oc1dean@yahoo.com&mu_id=
Action Points
  • Note that prior studies assessing the relationship between vitamin D status and markers of inflammation have yielded inconsistent results.


  • Point out that this study found a significant inverse relationship between CRP and 25-hydroxyvitamin D levels less than 21 ng/mL.

Low levels of vitamin D may confer a cardiovascular benefit, but too much vitamin D may have the opposite effect, according to a large cross-sectional study.

The critical threshold appears to be a serum 25-hydroxyvitamin D concentration of 21 ng/mL -- more than that level increases C-reactive protein (CRP), a biomarker for cardiovascular disease, but lower serum concentrations of 25-hydroxyvitamin D lower CRP levels, reported Muhammad Amer, MD, and Rehan Qayyum, MD, MHS, from Johns Hopkins University School of Medicine. Their findings were published online in the American Journal of Cardiology.

A multivariate analysis that tracked 25-hydroxyvitamin D concentrations as well as CRP in more than 15,000 healthy adults revealed that above the threshold for benefit, CRP increased with each 10-ng/mL increase in 25-hydroxyvitamin D.

In a univariate analysis, CRP levels decreased as levels of 25-hydroxyvitamin D increased up to the median of 21 ng/mL.

The authors analyzed data from participants in the National Health and Nutrition Examination Survey (NHANES). Researchers combined three two-year cycles of continuous NHANES surveys from 2001 to 2006.

The mean age of participants was 46, and the median serum 25-hydroxyvitamin D and CRP levels were 21 ng/mL and 0.21 mg/dL, respectively. The proportion of men to women was close, 48% versus 52%, with no significant difference in levels of 25-hydroxyvitamin D between the two groups.

Whites had significantly higher baseline levels of 25-hydroxyvitamin D than nonwhites.

Significantly more people with a body mass index greater than 30 kg/m2 had lower 25-hydroxyvitamin D levels at baseline (41% versus 25%, P<0.0001); the same was true for smokers (22% versus 18%, P=0.004).

However, the mean total cholesterol was significantly higher for those with higher levels of vitamin D at baseline (201.6 versus 198.6 mg/dL, P=0.001).

"From our results, it appears that vitamin D supplementation among asymptomatic subjects with baseline vitamin D values of greater than 21 ng/mL might have no additional effects on systemic inflammation, as measured by changes in the serum CRP levels," Amer and Qayyum concluded.

Researchers admitted they could not determine a temporal relation between 25-hydroxyvitamin D and CRP. Another limitation was the inability to adjust for geographic location or time of year.

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