Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, April 13, 2025

How Old Is Old? Rethinking the “Normal” Process of Aging

9 minute video at link, I'm not interested in this, I'm not planning on acting old even as I get old. 

I'm doing Hunter S. Thompson and Anthony Bourdain

Part of my Hunter S. Thompson journey;
“Life should not be a journey to the grave with the intention of arriving safely in a pretty and well preserved body, but rather to skid in broadside in a cloud of smoke, thoroughly used up, totally worn out, and loudly proclaiming "Wow! What a Ride!”

 How Old Is Old? Rethinking the “Normal” Process of Aging

Key Takeaways

  • Life expectancy has significantly increased over the past century, challenging traditional notions of normal aging and necessitating a reevaluation of aged-care delivery.
  • Patient-centered care should prioritize individual goals and preferences, with healthcare providers assisting in achieving these personalized objectives.
  • Pharmacists play a crucial role in compressing morbidity through therapeutics, offering significant potential in managing age-related health concerns.
  • Initiatives like the "age-friendly pharmacist" badge aim to motivate pharmacists to specialize in improving care for the aging population.

17 Modifiable Risk Factors Shared by Stroke, Dementia, and Late-Life Depression

 I haven't been depressed a day in my life and I certainly won't get dementia or another stroke.

17 Modifiable Risk Factors Shared by Stroke, Dementia, and Late-Life Depression

A wide range of modifiable risk and protective factors contribute to the combined burden of age-related brain disease, with high blood pressure, poor kidney function, high blood glucose, and smoking being among the strongest risk factors.

HealthDay News — Seventeen modifiable risk factors are shared by stroke, dementia, and late-life depression, according to a review published online in the Journal of Neurology, Neurosurgery & Psychiatry.

Jasper Senff, MD, from Massachusetts General Hospital in Boston, and colleagues conducted a systematic literature review to identify overlapping risk factors for stroke, dementia, and late-life depression and calculate their relative impact on a composite outcome.

Using data from 59 selected meta-analyses, the researchers identified the most likely risk factors for stroke, dementia, and late-life depression, using disability-adjusted life year (DALY)-weighted normalized β-coefficients (where positive values suggest increased risk and negative values suggest protective effects).

These are associated with increased risk:

  • Blood pressure (130) – strongest positive risk factor(Controlled by medicine)

  • Kidney function impairment (101)(None)

  • Smoking (91)(None)

  • Fasting plasma glucose (94)(Unknown)

  • Body mass index (BMI) (70)(Not worried about this, it's going down, no thanks to my stroke doctors)

  • Sleep issues (76)(None)

  • Hearing loss (60)

  • Depressive symptoms (57)(None)

  • Stress (55)(None)

  • Social engagement (low) (53)(Mine is very high)

  • Diet (poor) (51)(OK)

  • Pain (42)(None)

  • Total cholesterol (22)(Controlled by medicine)

These are associated with reduced risk (negative β-coefficients):

  • Leisure time cognitive activity (−91) – strongest protective factor(Writing this blog)

  • Physical activity (−56)(Walking 2-3 hours 3-4 times a week)

  • Purpose in life (−50)(Getting our fucking failures of stroke medical 'professionals' to solve stroke to 100% recovery!)

  • Alcohol (−34)(Used to massively increase my social connections! That's not going to change.)

“Dementia, stroke, and late-life depression are connected and intertwined, so if you develop one of them, there’s a substantial chance you may develop another one in the future,” Dr Senff said in a statement. “And because they share these overlapping risk factors, preventive efforts could lead to a reduction in the incidence of more than one of these diseases, which provides an opportunity to simultaneously reduce the burden of age-related brain diseases.”

Several authors disclosed ties to the pharmaceutical, medical device, and biotechnology industries.

Abstract/Full Text (subscription or payment may be required)

The Unexpected Science of Staying Happy

I must be an outlier then since I'm 69 and eternally happy. My social connections are very rich.

 The view out the deck of my condo I just bought.



 The Unexpected Science of Staying Happy

Every year, the World Happiness Report lands with a sense of global introspection: Which countries are thriving? Which are slipping? And what actually moves the needle on happiness? The 2025 report continues to offer compelling, often surprising insights—and while the headlines may not shock longtime wellness seekers, there’s fresh nuance in the data that’s worth a closer look.

What's New: Kindness Is the New Power Move

This year’s spotlight? Benevolence—not just as a warm fuzzy feeling, but as a measurable driver of wellbeing. Helping a stranger, giving to charity, or even expecting kindness from others turns out to be a stronger predictor of happiness than avoiding harm. In fact, expecting someone to return a lost wallet is nearly twice as predictive of happiness as performing frequent acts of kindness yourself​.

The takeaway? Trust and generosity aren’t soft skills—they’re longevity tools.

What’s Old But Still True: The Nordic Blueprint

Finland remains in the top spot (again), with Denmark, Iceland, and Sweden close behind. These countries share a few common threads: robust social support, freedom to make life choices, relatively low corruption, and a strong sense of community trust​. While that might sound familiar, the enduring dominance of these factors reinforces a powerful truth: long-term wellbeing is built on stability. What can we learn from Finland?

Finland's enduring happiness can be attributed to several cultural practices:

  • Embracing Natural Light: Maximizing exposure to sunlight during extended summer days enhances mood and health.​
  • Sauna Culture: Regular sauna use promotes relaxation and well-being.
  • Connection with Nature: Proximity to natural environments reduces stress and fosters creativity.​
  • Sisu: This Finnish concept of resilience and perseverance aids in navigating life's challenges.

What’s Concerning: Western Countries Are Sliding

The U.S., Canada, and Switzerland—all once top 10 contenders—have dropped out of the top 20 for the first time since the report began. That decline is linked to a drop in social trust and a rise in what researchers call “deaths of despair,” especially among men over 60​.

Translation: Longevity isn’t just about physical health—it’s about emotional safety and social infrastructure. And when those fray, the consequences are measurable.

What We Loved: Meal Sharing as a Happiness Metric

One charming detail tucked inside the data? Sharing meals with others is now being measured as a happiness driver. Turns out, “breaking bread” still has deep psychological roots in building social connection—and it’s being tracked across 142 countries​.

In French and Italian, the words for “friend” (copain, compagno) literally mean “with bread”—one of those moments when etymology feels quite poetic.

Four Lessons From The World Happiness Study

1. Longevity is social. Invest in high-quality connections: people who return your calls and your metaphorical wallets.

2. Be the kindness you want to see. Whether it’s volunteering or just making eye contact, benevolent acts boomerang.

3. Host more dinners. Science says meal-sharing = happiness. No surprise, but a timely reminder.

4. Rethink community. If you can’t move to Finland, build your own version. That means solid social support, deeper trust, and more transparency (yes, even in your friend group).
Happiness isn’t a destination—it’s a system! And like all good systems, it thrives with the right inputs: trust, connection, kindness, and consistency. This year’s report is a reminder that the most powerful longevity strategies may start with how we show up for one another.

Determinants of the time period from stroke onset to arrival at the emergency department: a GIS integrated hospital-based cross-sectional study

 Time to arrival is NOT A VALID EXCUSE for not getting survivors 100% recovered! My God, you'll use anything to deflect your responsibility to get survivors fully recovered! In the business world, running away from problems gets you fired!

Determinants of the time period from stroke onset to arrival at the emergency department: a GIS integrated hospital-based cross-sectional study

Abstract

Stroke is a serious public health problem in developing countries like India, leading to rising deaths and disability-adjusted life years related to stroke. Pre-hospital delay is a major concern in most acute stroke cases, affecting timely interventions and treatment outcomes. Hence the current study aimed to identify the factors influencing the time from stroke onset to arrival at the emergency department and to map the spatial distribution of stroke cases from the tertiary care hospital. We conducted a hospital-based cross-sectional study among stroke patients presenting to the emergency department of a tertiary care hospital in Mysuru. Data on sociodemographic, clinical, and pre-hospital factors, along with detailed addresses of the place of stroke onset, first and second consultation, and their proximal first referral units were collected. GIS mapping was done using the software ArcGIS v10.8.2, and statistical analysis was performed using SPSS v25. Most of the study participants were men, over 60 years of age, and residents from rural areas of Mysuru and its neighboring districts. The study found that only 25% of the stroke cases arrived within 4.5 h of symptom onset, with hemiparesis and slurred speech being the most common presenting complaints. Almost all the cases were within a 20 km radius of the first referral units with factors such as age group (p = 0.028), diabetes as a comorbid condition (p = 0.007), the decision taken for symptom onset (p < 0.01), the person involved in decision-making (p = 0.006), and the mode of arrival at the hospital (p = 0.004) being significantly associated with the duration from stroke onset to arrival at the hospital. This highlights the need for public awareness campaigns on stroke symptoms, the importance of early hospital presentation following stroke onset, and the capacity building of first referral units to provide timely emergency stroke care(NOT RECOVERY!) for people residing in rural areas.

Introduction

“Stroke is a syndrome of rapidly developing signs and symptoms of focal loss of cerebral function, caused by the sudden death of brain cells due to impaired blood flow to the brain.” It is a common non-communicable disease globally, contributing to morbidity, mortality, and financial burden to health systems1. Stroke is the leading cause of disability and the second leading cause of death worldwide2. As per the global fact sheet 2022, the lifetime risk of having a stroke has increased by 50% over the last 17 years, with one in every four individuals expected to suffer a stroke during their lifetime. A report from the World Stroke Organization and Lancet Neurology Commission projects stroke deaths will rise from 6.6 million in 2020 to 9.7 million by 2050, with low-and middle-income countries accounting for 86% of deaths and 89% of disability-adjusted life years (DALYs) related to stroke globally3.

In developing countries like India, stroke has become a serious public health problem due to the increasing prevalence of behavioral risk factors and sedentary lifestyles, contributing to rising incidence, deaths, and DALYs. In India, stroke is the fourth leading cause of death and the fifth leading cause of disability, with an estimated annual incidence of 105–152/100,000 population4.

The main pathological types of stroke include cerebral infarction, primary intracerebral hemorrhage, and subarachnoid hemorrhage. In most cases, ischemic stroke develops gradually while hemorrhagic stroke occurs suddenly. Stroke diagnosis is based on a comprehensive clinical examination, detailed history, and brain imaging through computed tomography (CT) or magnetic resonance imaging (MRI)5.

Treatment following a stroke is crucial, as the time to treatment significantly impacts the effectiveness of acute stroke therapies and patient outcomes6. Early hospital arrival allows for prompt medical intervention, leading to better outcomes7. The duration from stroke onset to arrival at the hospital depends on factors such as the ability to recognize the symptoms, timely transportation, referral, accurate diagnosis, and quick medical intervention. Pre-hospital delays are a major concern in many acute stroke cases, as they affect timely treatments like intravenous thrombolysis and mechanical interventions, ultimately affecting treatment outcomes6,8,9.

The Government of India has launched the “National Program for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases, and Stroke” (NPCDCS) to address the rising burden of non-communicable diseases, including stroke10. This program emphasizes early detection and management of stroke using stroke care(NOT RECOVERY!) algorithms across healthcare facilities, from primary health centers to district hospitals. However, gaps remain in stroke care(NOT RECOVERY!), especially in rural areas, leading to delayed hospital presentations11.

There is a fundamental relationship between geography and access to emergency care(NOT RECOVERY!) during a crisis. Geographic information systems and spatial data can be utilized to enhance equitable resource allocation and improve access to emergency medical services, particularly for people living in remote and rural areas, by considering the geographic distribution of cases and the availability of emergency-ready healthcare facilities12,13.

Hence the current study aims to describe the clinical profile of stroke patients at a tertiary care(NOT RECOVERY!) hospital in Mysuru, identify factors affecting the time from stroke onset to hospital arrival, and map the spatial distribution of stroke cases and the first referral units in the study area.

More excuses at link.

Saturday, April 12, 2025

Artificial intelligence, wearable tech can improve safety in stroke rehab: study

 

Sensors and wearables have been out for years and obviously NOTHING HAS BEEN DONE. 

  •  wearable (39 posts to April 2012)
  • wearable EMG (1 post to January 2024)
  • wearable arms (1 post to May 2013)
  • wearable computing (3 posts to August 2013)
  • wearable devices (38 posts to October 2015)
  • wearable electronic device (1 post to July 2020)
  • wearable exoskeletons (1 post to April 2022)
  • Wearable inertial measurement units (2 posts to June 2019)
  • wearable inertial sensor (2 posts to June 2023)
  • wearable motion-tracking (1 post to July 2023)
  • wearable robotics (1 post to July 2022)
  • wearable sensors (26 posts to January 2018)
    • The latest here: 

    Artificial intelligence, wearable tech can improve safety in stroke rehab: study

    Artificial intelligence combined with wearable technology has the potential to improve safety among people recovering from a stroke, suggests a study from researchers, including a team from Simon Fraser University in British Columbia.

    Gustavo Balbinot, an assistant professor in neurorehabilitation, said the research opens doors for the development of new technologies in stroke rehabilitation.

    The findings are also applicable for people at risk of falling due to balance challenges that aren’t related to stroke, such as vertigo or spinal injury, he said in an interview.

    The study published in the peer-reviewed journal Clinical Rehabilitation used sensors to monitor more than 50 stroke survivors as they performed mobility tasks.

    Researchers then used the data to generate movement patterns.

    “You can think about when you throw a rock into the river, you see those little waves,” Balbinot explained. “We can get those frequencies of the movement.”

    The analysis found those recovering from a stroke generally had smoother movements, suggesting a more cautious approach compared with a control group. Those healthy participants exhibited faster, more “jerky” movements, Balbinot said.

    Balbinot’s team has developed software that breaks the movement patterns down into three-second windows, allowing it to detect changes that could indicate a risk of falling – a potentially serious setback for someone recovering from stroke.

    “The software is the magic here,” said Balbinot, who leads the Movement Neurorehabilitation and Neurorepair laboratory at the B.C. university.

    “So, every three seconds, the software can detect, is it too wavy, is (it) oscillating a lot,” he said of a person’s movement pattern.

    The software is a step toward Balbinot’s goal of seeing it integrated into wearable technology, such as smart watches, to help people avoid dangerous falls.

    In the event the software detected a change, he said the user would then receive a warning informing them of potentially unstable or risky movement.

    “People may engage with dangerous movements, and they are not aware, and then eventually they fall,” Balbinot said.

    He said the real-time monitoring every three seconds is key to sending a message encouraging the user to perhaps slow down and avoid taking risks.

    “The software can say, ‘Hey, it’s dangerous what you’re doing here,’ so maybe it’s just sitting down for a while.”

    Balbinot said the predictions of fall risk would become more “assertive” as the software gathers data over time.

    “The algorithm learns with the person,” he said. “With machine learning, we can really make the software learn what’s good or bad for each person.”

    The sensors worn by participants monitor speed and orientation, said Balbinot, adding technology has advanced to the point that such monitoring tools may be embedded in the user’s clothing.

    The study notes clinicians would benefit from easy-to-interpret mobility data allowing them to help make informed decisions about patient care.

    “Incorporating machine learning algorithms could help personalize rehabilitation strategies by identifying individual movement patterns and predicting safety risks based on each patient’s unique needs,” the study concludes.

    “To bridge this gap, further studies focused on the long-term usability of these devices in clinical settings and their effectiveness in diverse patient populations will be essential,” it adds.

    This report by The Canadian Press was first published April 12, 2025.

    Brenna Owen, The Canadian Press

    Sound Spice Therapy May Ease Motion Sickness in Just One Minute: Researchers Find

     Would this help this? I bet your incompetent stroke medical 'professionals' haven't created a protocol to cure vertigo in stroke patients. Almost 5 years of incompetence!


  • 9% vertigo strokes (1 post to June 2021)

  • Sound Spice Therapy May Ease Motion Sickness in Just One Minute: Researchers Find

    Anticoagulant Use and Incident Intracerebral Hemorrhage: An Exploration of Hemorrhage Etiology and Location

     I don't see anything here that even minimally represents a protocol that would prevent this problem.

    Anticoagulant Use and Incident Intracerebral Hemorrhage: An Exploration of Hemorrhage Etiology and Location

    • Kristina A. Rankine , MD

    Wilson M, Incontri D, Vu S, Marchina S, Wang JY, Andreev A, Heistand E, Carvalho F, Selim M, Lioutas VA. Association of Anticoagulant Use With Hemorrhage Location and Etiology in Incident Spontaneous Intracerebral Hemorrhage. Stroke. 2024;55:2677–2684.

    Wilson et al. investigated the relationship between anticoagulant use and the location and etiology of intracerebral hemorrhage (ICH), focusing on whether hypertensive microangiopathy or cerebral amyloid angiopathy (CAA) is more likely to predispose patients to anticoagulant-associated ICH (AA-ICH). This research is crucial for clinicians managing anticoagulation therapy patients at risk for ICH.

    This was a cross-sectional analysis of 1,104 patients who experienced their first spontaneous ICH, admitted to a tertiary hospital in Boston between 2008 and 2023. Using MRI and CT imaging based on the Boston Criteria 2.0 and Simplified Edinburgh Criteria, the researchers examined whether AA-ICH was associated with lobar hemorrhages and probable CAA. There were statistically significant differences between the anticoagulant and no anticoagulant use groups with regards to sex, hypertension, hyperlipidemia, atrial fibrillation, coronary artery disease, smoking, statin use, and INR that they then ran a multivariable logistical regression model for analyses excluding those they felt lacked biological plausibility for an association. There was no significant difference in the occurrence of lobar hemorrhages between patients with and without anticoagulant exposure in their adjusted and unadjusted analyses. Additionally, using Vitamin K antagonists versus DOACs showed no difference in the probability of lobar hemorrhage.

    Interestingly, the study found that patients with AA-ICH were less likely to have probable CAA, which the researchers posit suggests that hypertensive microangiopathy might predispose more towards AA-ICH than CAA. This maintains the importance of rigorous blood pressure control in reducing ICH risk in anticoagulated patients and encourages more targeted management strategies focusing on hypertension in these patients.

    The authors discuss how their findings differ from research by Pezzini et al. that linked anticoagulation with increased risk of lobar ICH, particularly in the context of CAA,1 which they attributed to the inclusion of all cerebellar hemorrhages in the Pezzini study and the lower proportion of patients taking anticoagulation. Additionally, the authors discussed how their finding of a lack of association between AA-ICH and lobar hemorrhage and the reduced odds of probable CAA differs from the Edoxaban for Intracranial Hemorrhage Survivors with Atrial Fibrillation (ENRICH-AF). Interim data from ENRICH-AF found a high risk of recurrent lobar ICH in patients with lobar ICH and convexity SAH, suggesting CAA as a predisposing factor. The authors highlight the difference in the study populations with ENRICH-AF examining the risk of recurrent ICH in patients on anticoagulation with this study assessing anticoagulation use before first ICH.

    Further longitudinal and prospective cohort studies will help assess the long-term risk(Assessments do nothing; DO THE RESEARCH THAT PREVENTS THIS!) of incident and recurrent ICH in anticoagulated patients, considering hypertensive microangiopathy and CAA. They should also evaluate the correlation with the location of cerebellar hemorrhages. It may also be important to examine the trajectory of patients with initial ICH of suspected hypertensive etiology and the proportion that go on to develop CAA. Additional studies could explore the effect of comprehensive management strategies, including blood pressure control, on ICH incidence or delve further into AA-ICH pathophysiology.

    Wilson et al.’s study provides insights into the etiology of AA-ICH, suggesting a substantial role for hypertensive microangiopathy, and should encourage vigilant monitoring and treatment of hypertension to prevent ICH in clinical practice. Notably, considering the limitations of this cross-sectional study, further research to address these gaps should widen our understanding of anticoagulant use in relation to ICH.

    References at link.

    Transferrin and Borneol-Enhanced Liposomes for Targeted Rapamycin Delivery in TBI

     With all this earlier research on rapamycin  for stroke I bet our incompetent stroke medical 'professionals' have done ABSOLUTELY NOTHING! Aren't you glad they are so fucking incompetent that your children and grandchildren won't recover from a stroke? It took me all of two minutes to Google Scholar for 'rapamycin for stroke' and find all this; and I'm obviously stroke-addled and know nothing!

    Transferrin and Borneol-Enhanced Liposomes for Targeted Rapamycin Delivery in TBI

    Authors Cai S, Yuan Z, Chen Y, Gong M, Lai J, Yan P, Mei Z

    Received 29 July 2024

    Accepted for publication 28 February 2025

    Published 11 April 2025 Volume 2025:20 Pages 4503—4518

    DOI https://doi.org/10.2147/IJN.S489165

    Checked for plagiarism Yes

    Review by Single anonymous peer review

    Peer reviewer comments 2

    Editor who approved publication: Dr Kamakhya Misra



    Shihong Cai,1,2,* Zhongwen Yuan,1,* Yanfang Chen,3 Mingjie Gong,1 Jianqi Lai,1 Pengke Yan,1 Zhengrong Mei1

    1Department of Pharmacy, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Zhanjiang Healthcare Security Service Management Center, Zhanjiang, People’s Republic of China; 3Department of Pharmacy, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China

    *These authors contributed equally to this work

    Correspondence: Pengke Yan, Email gysyypk@126.com Zhengrong Mei, Email meizhengrong@126.com

    Background: The therapeutic potential of rapamycin (RAPA) for traumatic brain injury (TBI) is limited by its low bioavailability and poor penetration across the blood-brain barrier (BBB). We developed transferrin-modified rapamycin and borneol co-delivery liposomes (TF-RAPA/BO-LIP) to overcome these barriers, aiming to enhance both drug delivery to the brain and the treatment efficacy.
    Methods: We employed the emulsion-solvent evaporation method to prepare TF-RAPA/BO-LIP and characterized their particle size, zeta potential, morphology, stability, and encapsulation efficiency. Pharmacokinetic studies were conducted in SD rats, and drug concentration was analyzed using LC-MS/MS. The brain-targeting capability and therapeutic efficacy were evaluated through in vitro cellular uptake studies, and in vivo in a TBI mouse model using both neurological and cognitive assessments.
    Results: TF-RAPA/BO-LIP displayed optimal characteristics (95 nm particle size, > 90% encapsulation efficiency) and demonstrated enhanced stability. Pharmacokinetic analyses revealed reduced drug clearance and increased drug concentration-time curve area, indicating improved systemic and brain-specific drug bioavailability. Notably, TF-RAPA/BO-LIP achieved significantly higher RAPA accumulation in the brain tissue. Importantly, treatment with TF-RAPA/BO-LIP significantly ameliorated neurological deficits and improved spatial memory in TBI mice, as evidenced by behavioral tests.
    Conclusion: Our study highlights TF-RAPA/BO-LIP as a promising strategy for delivering RAPA across the BBB, substantially enhancing its therapeutic efficacy for TBI. This novel liposomal system not only improves RAPA bioavailability but also offers significant neuroprotection, potentially transforming the clinical management of TBI.

    Friday, April 11, 2025

    Folding paper failure by my stroke medical 'professionals'

     To get a normal 8.5 x 11in. papers into a business envelope it is almost impossible with a useless lefthand/fingers. With much effort I succeeded by using a ruler and heavy jars of coins. Multiple papers were needed since this was for taxes.

    Since my stroke medical team COMPLETELY FAILED at left hand recovery!  I've compensated, but NOT RECOVERED!




    A New Study Says When You Eat Is More Important Than When You Sleep

     I suppose this could also be considered Time-restricted eating, especially during the winter months.

    But what about this? Your competent? doctor better know the answer

    The latest here:

    A New Study Says When You Eat Is More Important Than When You Sleep


    After-hours meals have been linked to increased stress and clotting risks — even with the same amount of sleep.

    Stacey Leasca
    3 min read
    Key Points
    • A new study from Mass General Brigham found that eating only during daytime hours significantly reduces cardiovascular risk factors, such as elevated blood pressure and clotting protein levels.

    • The researchers used a tightly controlled lab setting to eliminate outside influences, making meal timing the only variable and directly linking nighttime eating to negative heart health outcomes.

    • The study found that eating in both the daytime and nighttime increased stress and clotting risks, while daytime-only eaters had better heart metrics.(But what about the research I listed above?)



    Timing is everything. And according to a new study by scientists at Mass General Brigham, that includes when you eat your food for optimal heart health, too.

    On April 8, researchers published their findings in the journal Nature Communications, assessing whether limiting meals to daytime hours could protect heart and blood vessel health, especially for those who are awake or asleep during irregular hours — such as night shift workers, individuals with sleep disorders, or frequent travelers across time zones.

    To reach their conclusion, the team conducted a carefully controlled lab study, splitting 20 healthy volunteers into two groups: a control group that ate their meals both during the day and at night to replicate real-world shift workers and their usual eating schedules, and an intervention group that only ate during the day. The participants took part in the study for two weeks, during which they had no access to windows, electronics, or watches, ensuring their bodies had no clues about the time of day.

    Related: Want Better Sleep? Here’s What to Ditch and What to Make for Dinner

    Part of that time was spent on a “forced desynchrony” schedule, meaning each “day” lasted 28 hours instead of the usual 24. They also went through two special “constant routine” periods, one lasting about 32 hours and the other about 40 hours, during which they stayed awake, reclined in a dimly lit room, and had hourly snacks — which does sound suspiciously like a typical workday these days.

    Then, they were asked to participate in "night work." Throughout the study, both groups maintained the same nap cycle to ensure they all had the same sleep cycle to measure against. This means the only difference between the two groups was their eating times.

    "Our study controlled for every factor that you could imagine that could affect the results, so we can say that it's the food timing effect that is driving these changes in the cardiovascular risk factors," Sarah Chellappa, MD, MPH, PhD, an associate professor at the University of Southampton, and lead author for the paper, shared in a statement.

    The Value of Crawling and Walking as a Rehabilitation

     If your doctor created nothing from the Pedro Bach-y-Rita case years ago you have a fucking incompetent doctor. I would argue you don't even have a doctor!

    The Value of Crawling and Walking as a Rehabilitation         

                 Two Holistic Rehabilitation and Recovery Consideration Possibilities

    Key points

    • A college professor suffered a catastrophic stroke.
    • A rehabilitation model based on the developmental progression of infants was initiated.
    • Three years of daily “child development crawling” rehabilitation led to a full recovery.

    In 1959, at the age of 65, Professor Pedro Bach-y-Rita, a college professor, suffered a catastrophic stroke (Doidge, 2010; Hunter, 1987; Purnell, 2015). Once he reached an appropriate level of recovery, and after consulting with all relevant medical staff—including Paul and George, the sons of Professor Bach-y-Rita—the hospital administration arranged to formally discharge the Professor into their care. This situation ultimately marked the beginning of a rehabilitation program developed by George, who was a medical student at the time.

    Initially, George felt uncertain about his next steps. Ultimately, he determined that his father's rehabilitation model would be grounded in the developmental movement progression of infants (Doidge, 2010). He remarked, “The only model I had was how babies learn…to walk” (Doidge, 2010, p. 21). According to White et al. (2013), children start to advance to crawling between six to ten months of age, building their skills as a result of all the developmental movements that occurred since birth, which continually shape the infant's brain and body.

    And So, the Crawling Rehabilitation Began

    The crawling stage also includes a markedly more advanced and intricate movement progression that engages all four limbs. This complex movement progression allows infants to navigate independently within and around their environment.

    This stage represents the ongoing development of both the brain and body, ultimately leading to the point when, by the age of 12 to 15 months, infants can take their first steps without assistance, marking the onset of walking (Adolph et al., 2012).

    Keeping this universal developmental model in mind, George explained to his father that infants ultimately learn to walk through crawling (Doidge, 2010). Thus, the crawling rehabilitation commenced.

    Three years of daily “child development crawling” rehabilitation followed, resulting in what might be considered a full recovery (Bach-y-Rita, 1980; Doidge, 2010; Hunter, 1987; Purnell, 2015). This rehabilitation approach and the resultant recovery completely contradicted the prevailing medical wisdom of that time.

    The Value and Significance of Crawling as a Holistic Rehabilitation Modality

    Interestingly, related to this, George and Paul were ridiculed at the time for allowing something as “humiliating” as crawling like a baby to happen to their father (see Bach-y-Rita, 1980). Doidge (2015) emphasises the importance of crawling by referring to the work of Moshé Feldenkrais, who highlighted its value and significance as a holistic rehabilitation modality.

    Moshé Feldenkrais believed that walking depends on the neurological and neuromuscular foundational support provided by crawling. According to Doidge (2015, p. 189), Feldenkrais argued that any “attempts to leapfrog through development is a huge error.”

    The Return to His Position as a College Professor

    article continues after advertisement

    Doidge (2015, p. 189) also argued that “no one ever learned to walk by walking. Other skills must be in place for a child to walk—skills that adults don’t think about or remember learning.” As noted above, it was this daily recovery regimen centred around crawling that ultimately led to the situation where Professor Bach-y-Rita could return to his position as a college professor three years after his stroke.

    Former World Boxing Champion John Famechon
    Former World Boxing Champion John Famechon
    Source: Source John Famechon and Frank Quill The Method

    Famechon, Bach-y-Rita, Feldenkrais

    With Moshé Feldenkrais mentioned, I'll include his story. I believe this information about Feldenkrais, as with Bach-y-Rita, provides valuable medical and holistic acquired brain injury (ABI) rehabilitation background that can be compared and contrasted to the ABI recovery of former World Boxing Champion John Famechon.

    Feldenkrais, Soccer, Judo, Physics

    Moshé Feldenkrais was born in Ukraine in 1904, at that time part of the Russian Empire. Three major influences shaped his life: soccer, judo, and his studies in physics. His soccer career ended after he sustained a knee injury. Although he recovered, Feldenkrais continued to experience constant pain following the injury.

    Due to this ongoing pain, Feldenkrais began to adjust his walking. He also increasingly relied on his non-injured leg for movement. While this helped minimise the pain, favoring his non-injured leg ultimately led to signs of muscular atrophy in his injured leg.

    While all of this was happening, Feldenkrais was also training in judo. After injuring his knee, he could no longer play soccer, but he maintained an interest in judo. Despite his knee injury, Feldenkrais continued to pursue this interest. However, even with his involvement in judo, Feldenkrais experienced difficulty walking, which, as noted, led to signs of atrophy in his soccer-injured leg.

    A Forever Life Changing Circumstance

    In the mid-1930s, Feldenkrais was living in Paris. One day, while walking down the street, he slipped and injured his ‘good’ leg. Now, Feldenkrais had two injured legs, forcing him to hobble home. By the time he finally arrived, he was utterly exhausted.

    Due to this exhaustion, instead of administering first aid to his recently injured leg, Feldenkrais chose to go to bed and rest (with the hopeful possibility of sleep). He eventually fell into a deep and heavy sleep. The significance of this injury to his healthy leg and his choice to immediately go to bed, rest, and then sleep transformed Feldenkrais's thinking and life forever (Doidge, 2015).

    When Feldenkrais awoke, he discovered that he could now stand on his long-injured and painful leg. He thought he was going mad. “How could a knee that had prevented me from standing for several months suddenly become usable and nearly painless?” Feldenkrais asked himself (Doidge, 2015, p. 165).

    Reflection and Neuroscience

    This prompted Feldenkrais to reflect on his interest in neuroscience and his readings on the subject. His interests and studies led him to hypothesise that the absence of pain in his previously injured’ soccer knee” was due to changes occurring in his brain and central nervous system.

    Feldenkrais believed that “the acute trauma” to his now injured “good leg” somehow provided the neurological means to alter his brain in a way that inhibited the motor cortex brain maps of his ‘good leg,” which, as noted, was now his newly injured leg (Doidge, 2015, p. 165).

    According to Feldenkrais, these changes in his brain occurred unconsciously, and as Feldenkrais reflected, “the purpose of which was to protect [his newly injured leg] from further injury should he [try to] move” that injured leg (Doidge, 2015, p. 165). This unexpected recovery led Feldenkrais to conclude that it was his brain, not just his body, that “was in charge of his level of functioning” (Doidge, 2015, p. 165).

    Improbable

    Doidge (2015, p. 165) rightly points out that all of this does seem like an improbable “new age wishy-washy fairy tale of recovery.” Two injured knees: one long-term, one short-term. Both injuries result in pain, and then, somehow, after walking home on these two injured legs without any form of first aid treatment, Feldenkrais goes to bed to rest and sleep. When he wakes up, the injury and pain of his newly injured leg have “disappeared!” How was this at all possible?

    References at link. If your doctor has not read all of these; THAT IS PROOF OF COMPLETE

    Parmesan cheese failure by my stroke medical 'professionals'

     After sprinkling parmesan cheese on pizza there is usually stray bits left on the plate. The normal course is to steady the plate and use your finger to pick them up. Since my stroke medical team COMPLETELY FAILED at left hand recovery, I can't steady the plate at all, it skitters around until it bumps into my drink glass. I've compensated, but NOT RECOVERED!



    Dopaminergic Pathways in Neuroplasticity After Stroke and Vagus Nerve Stimulation.

     Still haven't created vagus nerve protocols!

    Steven Cramer should know what needs to be done since he is one of strokes' rock stars.

  • Dr. Steven Cramer (23 posts to October 2011)
  • Dopaminergic Pathways in Neuroplasticity After Stroke and Vagus Nerve Stimulation.

    Min-Keun Song, Steven C Cramer

    Stroke. 2025 Apr 10 [Epub ahead of print]

    Stroke remains a significant cause of disability worldwide. In addition to multidisciplinary rehabilitation approaches, various forms of technology, including vagus nerve stimulation, have emerged to facilitate neuroplasticity and, thereby, improve functional status after stroke. Vagus nerve stimulation was recently approved by the Food and Drug Administration, but questions remain regarding its mechanism of action. Here, a potential role for dopaminergic signaling is considered. This review first examines evidence that dopamine is important to neuroplasticity after stroke. Next, 2 different dopaminergic pathways are considered potential mechanisms underlying vagus nerve stimulation-related benefits after stroke, direct modulation of brain dopaminergic pathways, and engagement of systemic dopaminergic pathways such as those found in the gut-brain axis. A contribution of dopamine signaling to vagus nerve stimulation efficacy could have therapeutic implications that extend to a precision medicine approach to stroke rehabilitation.
    Source: Stroke

    Risk of Recurrent Stroke After TIA or Minor Stroke Is High, 10% of Which May Be Fatal

    Well then, create EXACT PROTOCOLS THAT PREVENT THIS PROBLEM! Isn't that the logical solution?

    WHY THE FUCK CAN'T YOU PROVIDE THAT?

    Laziness? Incompetence? Or just don't care? NO leadership? NO strategy? Not my job? Not my Problem?

    Risk of Recurrent Stroke After TIA or Minor Stroke Is High, 10% of Which May Be Fatal

    Within 10 years of experiencing a transient ischaemic attack (TIA) or minor stroke, approximately 1 in 5 patients were at risk of having another stroke and 10% of all subsequent stroke events were likely to be fatal, according to a systematic review and meta-analysis published in JAMA.

    The annual risk of stroke decreased from 5.9% in the first year to an average of 1.8% per year thereafter. However, the cumulative risk of stroke continued to increase over time. Notably, half of all subsequent strokes occurred after the first year.

    “This risk of subsequent stroke events is high but is not readily apparent in routine clinical practice due to its gradual onset over time,” wrote Faizan Khan, PhD, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, and colleagues. “Given that many secondary prevention clinics only monitor patients for the first 90 days, with long-term preventive care often transitioning to primary care physicians and internists, the current findings emphasise the importance of ongoing vigilant monitoring and risk reduction strategies beyond the initial high-risk period.”

    The analysis involved 171,068 patients from 38 studies. The patient population consisted of TIA or minor stroke in 17 studies, TIA only in 20 studies, and minor stroke only in 1 study. There were 24 studies that reported the primary outcome of stroke beyond 1 year of follow-up, 12 studies that reported stroke beyond 5 years of follow-up, and 10 studies that reported stroke up to 10 years of follow-up

    The pooled rate of stroke per 100 person-years was 5.94 events (38 studies; I2 = 97%) in the first year; 1.80 events (25 studies; I2 = 90%) annually in the second through fifth years; and 1.72 events (12 studies; I2 = 84%) annually in the sixth through tenth years.

    Based on an analysis of 32 included studies with data available for the first 90 days, and day 91 through 365 separately, 2,932 of 4,749 (61.7%) subsequent stroke events in the first year occurred within the initial 90 days. The pooled rate of stroke per 100 person-years was 16.09 events in the first 90 days and 3.04 events between 91 and 365 days.

    Among the 10 included studies with a maximum follow-up duration of 10 years, 1,707 of 3,390 (50.4%) subsequent stroke events occurred after the first year. The 5- and 10-year cumulative incidences of stroke were 12.5% and 19.8%, respectively.

    Based on an analysis of 17 included studies with data available on both fatal stroke (n = 269) and any stroke (n = 2,737), the pooled case-fatality rate of subsequent stroke was 10.4%.

    Stroke rates were higher in studies conducted in North America and Asia compared with Europe, in cohorts recruited in or after 2007, and in studies that used active versus passive outcome ascertainment methods. According to the authors, the fact that the risk of subsequent stroke after a TIA or minor stroke appears to have increased in the modern era deserves attention and further research.

    “Patients who have had a TIA or minor stroke are at a persistently high risk of experiencing a subsequent stroke,” the authors concluded. “TIA or minor stroke events also portend a significant risk of long-term disability and death. Findings from this study underscore the need for improving long-term stroke prevention measures in this patient population.”

    Reference: https://jamanetwork.com/journals/jama/fullarticle/2832005

    SOURCE: JAMA

    Novel Risk Score to Predict Poor Outcome After Endovascular Treatment in Anterior Circulation Occlusive Acute Ischemic Stroke

     This is the problem, predicting failure to recover rather than DELIVERING RECOVERY! I'd have you all fired!

    Novel Risk Score to Predict Poor Outcome After Endovascular Treatment in Anterior Circulation Occlusive Acute Ischemic Stroke


    Journal of the American Heart Association

    Abstract

    Background

    We aimed to develop and validate a prognostic score to predict outcomes after endovascular treatment in acute ischemic stroke.

    Methods

    The prognostic score was developed based on the ACTUAL (Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke) registry. The validation cohort was derived from the Captor trial. Independent predictors of poor outcome after endovascular treatment were obtained from the least absolute shrinkage and selection operator regression and multivariable logistic regression. Corresponding regression coefficients were used to generate point scoring system. The area under the receiver operating characteristic curve and the Hosmer–Lemeshow goodness‐of‐fit test were used to assess model discrimination and calibration. The predictive properties of the developed prognostic score were validated and the discriminative power was compared with other validated tools.

    Results

    A 17‐point Age, Collateral Status, Blood glucose, Alberta Stroke Program Early Computed Tomography Score, and National Institutes of Health Stroke Scale score scale was developed from the set of independent predictors, including age, admission National Institutes of Health Stroke Scale score, Alberta Stroke Program Early Computed Tomography Score on initial computed tomography scan, blood glucose, and collateral status. The scale showed good discrimination in the derivation cohort (area under the receiver operating characteristic curve, 0.79 [95% CI, 0.75–0.82]) and validation cohorts (area under the receiver operating characteristic curve, 0.77 [95% CI, 0.70–0.84]). The scale was well calibrated (Hosmer–Lemeshow test) in the derivation cohort (P=0.57) and validation cohort (P=0.75).

    Conclusions

    The Age, Collateral Status, Blood glucose, Alberta Stroke Program Early Computed Tomography score, and National Institutes of Health Stroke Scale score scale is a valid tool for predicting outcomes and may be useful for endovascular stroke treatment in anterior circulation large vessel occlusions.

    American Heart Association receives $6.8M for stroke care in Hawaii

     

    This is the whole problem in stroke enumerated in one word; 'care'; NOT RECOVERY!

    YOU have to get involved and change this failure mindset of 'care' to 100% RECOVERY! Survivors want RECOVERY, NOT 'CARE'!

    I see nothing here that states going for 100% stroke recovery! Chance for full recovery is not enough. You need to create EXACT PROTOCOLS FOR THAT!

    ASK SURVIVORS WHAT THEY WANT, THEY'LL NEVER RESPOND 'CARE'! This tyranny of low expectations has to be completely rooted out of any stroke conversation!

    RECOVERY IS THE ONLY GOAL IN STROKE! GET THERE!

    American Heart Association receives $6.8M for stroke care in Hawaii

    HONOLULU (HawaiiNewsNow) - Hawaii has received a major donation to expand and strengthen stroke care(NOT RECOVERY!) in the islands.

    The $6.8 million commitment from the Leona M. and Harry B. Hemsley Charitable Trust and the American Heart Association will go toward implementing the association’s “Misson: Lifeline Stroke” program in Hawaii.

    The program connects all components of acute stroke care(NOT RECOVERY!), including hospitals, first responders, rehab facilities, and government into an integrated system to timely and effectively treat stroke patients.

    “With the clock ticking, it’s essential that all parts of the health care system are linked together effectively for seamless care(NOT RECOVERY!),” said Dr. Debleena Dutt, American Heart Association Hawaii board member. “The mission lifeline model works across pre-hospital, rehabilitation and post-acute phases to ensure that all stroke patients receive the best possible chance at survival and full recovery.”(NOT GOOD ENOUGH!)

    Stroke is the third leading cause of death in Hawaii and the number one cause of disability. 

    50% improvement in balance in stroke patients follows rehab scheme by medics and PTs

     NOT GOOD ENOUGH! Still a failure at 100% recovery; The only goal in stroke! Why are you allowing your stroke medical team to use the tyranny of low expectations on you? You need to be SCREAMING 100% RECOVERY ALL THE TIME!

    50% improvement in balance in stroke patients follows rehab scheme by medics and PTs

    A partnership between the NHS and exercise professionals demonstrates the power of collaboration
    Active Sussex Reconditioning Project provided 54 supervised physical activity sessions for stroke survivors
    The rehab programme began in hospital and continued into the community
    There are hopes to roll this blueprint out more widely in Sussex

    A Sussex hospital-based stroke rehabilitation programme, delivered by health instructors and NHS physiotherapists, has seen far-reaching benefits and there are now hopes to extend it further.

    Over the course of 26 weeks, the Active Sussex Reconditioning Pilot provided 54 supervised physical activity sessions, led by health instructors from 20/20 Health, alongside physiotherapists at the Irvine Rehabilitation Unit at Bexhill Hospital.

    Patients received four sessions a week in the hospital – an average of nine extra hours of exercise(That is the reason for the extra improvement! Figure out how to deliver that to all stroke patients and survivors will recover much better.) – in addition to community-based provision in Hastings, Bexhill, Lewes and Eastbourne.

    Early data analysis shows patients experienced a 50 per cent improvement in balance, a 34 per cent increase in sit-to-stand ability, and a 22 per cent reduction in rehabilitation complexity – offering them greater independence and improved recovery.

    Karen Poole, AHP rehabilitation consultant for East Sussex Healthcare NHS Trust and strategic clinical lead for rehabilitation and reablement at NHS Sussex, says The Active Sussex Reconditioning Pilot serves as an exemplar of what can be achieved when the fitness and healthcare sectors team up.

    “Increased access to physical and social activity for patients contributed to their mood, wellbeing and a positive culture across our workforce,” she explains. “This pilot has also tested how we can work with non-NHS partners in traditional NHS environments, paving the way for greater confidence in this approach.”

    Ross Joannides, strategic relationship manager at Active Sussex, says: “Bringing health instructors into the hospital setting where they can work with NHS staff to address the issue of deconditioning and then transition patients into community-based activity is a significant step forward for the way Active Sussex wants to support the health system at a local level.

    “The project has shown how voluntary and community-based partners can work with statutory organisations to overcome governance challenges to deliver a service that has had a significant impact on patients’ health outcomes.”

    An unexpected barrier that was encountered was getting patients to the community classes once they had returned home. In order to make the classes more accessible there are plans to offer classes at multiple places in the community.

    The programme was funded by the Active Partnership and delivered in partnership with East Sussex Healthcare NHS Trust, Active Rother, East Sussex Public Health and 20/20 Health.

    Subject to additional funding, the project team aims to live-stream exercise sessions from the Irvine Unit to other hospitals across East Sussex, potentially expanding further into West Sussex. Such scaling up could create a ripple effect, inspiring other hospital trusts to adopt this successful model.

    Predominantly funded by Sport England, Active Sussex is one of 43 Active Partnerships across England that aims to address inequality and empower everyone to be active in a way that works for them.