Coffee drinkers have less fat, more muscle, and surprising hormone differences: Study

 Will your incompetent? doctor and hospital ever come around to a 24 hour coffee station? Or are they mired in ignorance and absolute stupidity?

How coffee protects against Parkinson’s Aug. 2014 

Coffee May Lower Your Risk of Dementia Feb. 2013

Coffee drinkers rejoice! Drinking coffee could lower the risk of Alzheimer’s disease 

And this: Coffee's Phenylindanes Fight Alzheimer's Plaque December 2018

New research suggests drinking coffee may reduce the risk of frailty May 2025

I think I'm in this category:  I never get the jitters or flushed skin.

Genetics determine how much coffee you can drink before it goes wrong

I'm doing a 12 cup pot of coffee a day with full fat milk to lessen my chances of dementia and Parkinsons. Tell me EXACTLY how much coffee to drink for that and I'll change. Yep, that is a lot more than the 400mg. suggested limit, I don't care! Preventing dementia and Parkinsons is vastly more important than whatever problems it can cause! 

Of course, your fuckingly incompetent? doctor did nothing with this from 3+ years ago! And still hasn't created a 24 hour coffee station

Dementia risk could drop by drinking just one shot daily of common beverage  August 2023

This line is great: The findings indicate that even the Espresso Martini cocktail contains the espresso's beneficial compounds - and can contribute to staving off dementia.

The latest here: 

Coffee drinkers have less fat, more muscle, and surprising hormone differences: Study

Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging

Your competent? doctor created protocols on this years ago, right? Oh NO! YOUR DOCTOR, HOSPITAL AND BOARD OF DIRECTORS ARE ALL COMPPLETELY INCOMPETENT!     

So, they actually prefer wallowing in their ignorance, doesn't require as much brainpower!

renin angiotensin system (2 posts to October 2016)

 Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging

 Sebastián García Menéndez, Felipe Inserra, Elena MV de Cavanagh, Leon Ferder, Walter Manucha Sebastián García Menéndez, Department of Pathology, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza 5500, Argentina Felipe Inserra, Department of Postgraduate, Austral University, Pilar 1630, Argentina Elena MV de Cavanagh, Department of Postgraduate, Austral University Hospital, Arterial Hypertens Ctr, Sch Biomed Sci, CABA 1629, Argentina Leon Ferder, Department of Pharmacology, Universidad Maimónides, Ciudad Autónoma de Buenos Aires C1405, Argentina Walter Manucha, Department of Pathology, Institute of Medicine and Experimental Biology of Cuyo, National Council for Scientific and Technological Research, National University of Cuyo, Laboratory of Basic and Translational Experimental Pharmacology, Faculty of Medical Sciences, Mendoza 5500, Argentina ORCID number: Walter Manucha (0000-0002-2279-7626). Author contributions: García Menéndez S, Inserra F, de Cavanagh EMV, Ferder L and Manucha W were responsible for writing, discussion and preparation of this manuscript, and have also read and approved the final version of the manuscript. Conflict-of-interest statement: The authors declare that they have no conflict of interest. Corresponding author: Walter Manucha, PhD, Professor, Department of Pathology, Institute of Medicine and Experimental Biology of Cuyo, National Council for Scientific and Technological Research, National University of Cuyo, Laboratory of Basic and Translational Experimental Pharmacology, Faculty of Medical Sciences, Avenue El Libertador 80, Mendoza 5500, Argentina. wmanucha@yahoo.com.ar Received: August 20, 2025 Revised: October 25, 2025 Accepted: January 20, 2026 Published online: March 20, 2026 Processing time: 207 Days and 13.6 Hours 

 Abstract 

Although aging is an inherent part of life, it represents a process of progressive dysfunction rather than a fixed biological outcome. Consequently, highly prevalent conditions such as cardiorenal-metabolic syndrome-which encompasses obesity, hypertension (HTN), and metabolic disorders-can accelerate age-related changes. The renin-angiotensin system (RAS) plays a critical role in pathophysiology and affects multiple organs, including the brain. The central nervous system contains both RAS branches: The ACE/Ang II/AT1 and AT2 receptor axis, as well as the ACE2/Ang-(1-7)/Mas receptor axis. Neuroinflammation is a chronic process characterized by glial cell activation triggered by increased production of reactive oxygen and nitrogen species, resulting in oxidative stress. Mitochondria are the primary cellular sites where these processes occur. Under conditions such as metabolic disorders, obesity, HTN, and aging, these reactions are markedly accelerated. Associated mechanisms include insulin resistance, elevated levels of advanced glycation end-products, and disruption of the blood-brain barrier. The consequences of these alterations may include brain dysfunction, cognitive decline, Parkinson’s disease, and neurodegenerative conditions such as Alzheimer’s disease. This review focuses on the primary effects of therapeutic interventions on mitochondrial function, with particular attention to the modulation of oxidative stress, chronic neuroinflammation, and glial dysregulation. We highlight the strategic use of angiotensin receptor blockers and ACE2 activators as promising tools that may redefine the prevention and treatment of vascular dementia and other neurodegenerative diseases of inflammatory origin. 

 Key Words: Renin-angiotensin system blockade; Oxidative stress; Central nervous system inflammation; Neurodegeneration; Hypertension; Metabolic disorders; Mitochondria; Aging Core Tip: This study highlights renin-angiotensin system blockade as a promising strategy for preventing brain damage associated with hypertension, metabolic disorders, and aging. These conditions accelerate mitochondrial dysfunction, oxidative stress, and neuroinflammation. Our work focuses on the strategic use of angiotensin receptor blockers and ACE2 activators, demonstrating their potential to mitigate these pathological processes and offering a novel avenue for the prevention and treatment of vascular dementia and other neurodegenerative diseases. Citation: García Menéndez S, Inserra F, de Cavanagh EM, Ferder L, Manucha W. Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging. World J Exp Med 2026; 16(1): 113259 URL: https://www.wjgnet.com/2220-315x/full/v16/i1/113259.htm DOI: https://dx.doi.org/10.5493/wjem.v16.i1.113259

García Menéndez S, Inserra F, de Cavanagh EM, Ferder L, Manucha W. Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging. World J Exp Med 2026; 16(1): 113259 [DOI: 10.5493/wjem.v16.i1.113259]

The Effectiveness of the Bobath Concept in Stroke Rehabilitation: What is the Evidence?

Were your mentors and senior researchers so ignorant that they missed this research from 2003  proving it doesn't work?  I suppose I shouldn't complain too much, the latest paper is from 2009, so they only had 6 years to update their knowledge.

Physiotherapy Based on the Bobath Concept for Adults with Post-Stroke Hemiplegia: A Review of Effectiveness Studies

The latest waste of time here:

The Effectiveness of the Bobath Concept in Stroke Rehabilitation: What is the Evidence?

 Boudewijn J. Kollen, PhD; Sheila Lennon, PhD; Bernadette Lyons, MSc; Laura Wheatley-Smith, BSc;Mark Scheper, MSc; Jaap H. Buurke, PhD; Jos Halfens;Alexander C.H. Geurts, MD, PhD; Gert Kwakkel, PhD
 Background and Purpose
—In the Western world, the Bobath Concept or neurodevelopmental treatment is the most popular treatment approach used in stroke rehabilitation, yet the superiority of the Bobath Concept as the optimal type of treatment has not been established.(Yes it has, you just don't keep up-to-date in your research field.) This systematic review of randomized, controlled trials aimed to evaluate the available evidence for the effectiveness of the Bobath Concept in stroke rehabilitation.
 Method
—A systematic literature search was conducted in the bibliographic databases MEDLINE and CENTRAL (March2008) and by screening the references of selected publications (including reviews). Studies in which the effects of theBobath Concept were investigated were classified into the following domains: sensorimotor control of upper and lowerlimb; sitting and standing, balance control, and dexterity; mobility; activities of daily living; health-related quality of life; and cost-effectiveness. Due to methodological heterogeneity within the selected studies, statistical pooling was notconsidered. Two independent researchers rated all retrieved literature according to the Physiotherapy Evidence Database(PEDro) scale from which a best evidence synthesis was derived to determine the strength of the evidence for botheffectiveness of the Bobath Concept and for its superiority over other approaches.
 Results
—The search strategy initially identified 2263 studies. After selection based on predetermined criteria, finally, 16 studies involving 813 patients with stroke were included for further analysis. There was no evidence of superiority of Bobath on sensorimotor control of upper and lower limb, dexterity, mobility, activities of daily living, health-related quality of life, and cost effectiveness. Only limited evidence was found for balance control in favor of Bobath. Because of the limited evidence available, no best evidence synthesis was applied for the health-related quality-of-life domain and cost-effectiveness.
Conclusions
—This systematic review confirms that overall the Bobath Concept is not superior to other approaches. Based on best evidence synthesis, no evidence is available for the superiority of any approach. This review has highlighted many methodological shortcomings in the studies reviewed; further high-quality trials need to be published.Evidence-based guidelines rather than therapist preference should serve as a framework from which therapists should derive the most effective treatment.
 (Stroke. 2009;40:00-00.)

Minor stroke due to large artery occlusion. When is intravenous thrombolysis not enough? Results from the SITS International Stroke Thrombolysis Register

Thrombolysis is never enough. Because you are fucking ignoring the neuronal cascade of death. 
Are you that ignorant of stroke etiology? 

Minor stroke due to large artery occlusion. When is intravenous thrombolysis not enough? Results from the SITS International Stroke Thrombolysis Register 

Show all authors

Michael V Mazya, Charith Cooray, Kennedy R Lees, ...

First Published November 29, 2017 Research Article

https://doi.org/10.1177/2396987317746003

Article information

Abstract

Purpose

Beyond intravenous thrombolysis, evidence is lacking on acute treatment of minor stroke caused by large artery occlusion. To identify candidates for additional endovascular therapy, we aimed to determine the frequency of non-haemorrhagic early neurological deterioration in patients with intravenous thrombolysis-treated minor stroke caused by occlusion of large proximal and distal cerebral arteries. Secondary aims were to establish risk factors for non-haemorrhagic early neurological deterioration and report three-month outcomes in patients with and without non-haemorrhagic early neurological deterioration.

Method

We analysed data from the SITS International Stroke Thrombolysis Register on 2553 patients with intravenous thrombolysis-treated minor stroke (NIH Stroke Scale scores 0–5) and available arterial occlusion data. Non-haemorrhagic early neurological deterioration was defined as an increase in NIH Stroke Scale score ≥4 at 24 h, without parenchymal hematoma on follow-up imaging within 22–36 h.

Findings

The highest frequency of non-haemorrhagic early neurological deterioration was seen in 30% of patients with terminal internal carotid artery or tandem occlusions (internal carotid artery + middle cerebral artery) (adjusted odds ratio: 10.3 (95% CI 4.3–24.9), p < 0.001) and 17% in extracranial carotid occlusions (adjusted odds ratio 4.3 (2.5–7.7), p < 0.001) versus 3.1% in those with no occlusion. Proximal middle cerebral artery-M1 occlusions had non-haemorrhagic early neurological deterioration in 9% (adjusted odds ratio 2.1 (0.97–4.4), p = 0.06). Among patients with any occlusion and non-haemorrhagic early neurological deterioration, 77% were dead or dependent at three months.

Conclusions

Patients with minor stroke caused by internal carotid artery occlusion, with or without tandem middle cerebral artery involvement, are at high risk of disabling deterioration, despite intravenous thrombolysis treatment. Acute vessel imaging contributes usefully even in minor stroke to identify and consider endovascular treatment, or intensive monitoring at a comprehensive stroke centre, for patients at high risk of neurological deterioration.

Is ignorance the problem? For solving stroke?

These lines from Seth Godin here are indicative of the stroke problem I'm trying to solve. To get our stroke professionals to solve all the fucking problems in stroke, rather than sticking their heads up their asses and ignoring survivors.  Our stroke medical professionals don't seem to care about what stroke survivors want to accomplish. 100% recovery for all. 
http://sethgodin.typepad.com/seths_blog/2017/03/is-ignorance-the-problem.html

The thing is, ignorance is rarely the problem.
The challenge is that people don't always care about what you care about. And the reason they don't care isn't that they don't know what you know.

My ignorance is just as good as your knowledge - Isaac Asimov

Is this what your doctor is using to not have any stroke protocols that get you anywhere close to 100% recovery?
Damn, I should stay away from flubbing 'How to win Friends and Influence People'.
But I actually expect my doctors to know more about my condition/recovery than I do.

Canadian marijuana companies are smiling after last night's election stunner

Well at least the people in the northern states might have it easier. I would only have to drive 100 miles to Windsor instead of 17 hours to Colorado. And if your doctor isn't already looking into marijuana for stroke you have a doctor that should be fired. But don't listen to me, I'm obviously stroke-addled. I've pretty much given up on medical marijuana, we've got fucking neanderthal legislators that wouldn't understand science research if it burned a hole in their ass.
Willfully ignorant assholes.
My reasons here;
My 13 reasons for marijuana use post-stroke. Don't follow me but I will figure out some way to get some after my next stroke.
 Treating brain diseases with marijuana 



http://finance.yahoo.com/news/canadian-marijuana-companies-smiling-last-173040362.html
Of all the industries across Canada, none could possibly be happier with Monday’s surprising election result than the medical marijuana sector, Peter Koven of Canada's Financial Post reports.

Justin Trudeau — who won in a landslide — has a plan to legalize marijuana promises to bring massive opportunity to an industry that only came into existence last year.

Marijuana equities moved higher on Tuesday as investors absorbed the news.

Shares of Canopy Growth Corp. (formerly Tweed Marijuana) climbed 2.75% while Aphria Inc.’s shares climbed 5% as of 1:20 ET.

The federal government birthed the marijuana sector in April 2014, when it introduced rules that required medical pot patients to buy their product from licensed producers.

That created a market frenzy as dozens of companies popped up out of nowhere to get into the sector. Those firms are slowly being whittled down to a much smaller group of capable long-term producers.

But while the medical marijuana patient list is growing, it is still below 30,000 people across the country.

That is a tiny number, and it limits the amount of money these companies can possibly make. As of now, none of the major producers are cash flow positive.

Legalization, if it indeed happens, will transform the business because the potential customer base is enormous.

Assuming Canada follows the path of U.S. states like Colorado and Oregon that have legalized, pot will become huge business literally overnight.

But that will also bring big challenges to the marijuana producers. Higher production could drive prices down, which would force plenty of companies out of business if they cannot establish enough scale to drive down their costs. Consolidation, which is already happening, will likely become a must.

The regulatory environment under legalization is completely uncertain. And a legalized marijuana industry could also draw interest from the global tobacco and pharmaceutical industries. If they bring their scale and know-how to pot, it may become impossible for the small Canadian firms to hold their ground.

Coffee associated with colon cancer survival

Another reason for my coffee addiction. Does your doctor have coffee in your stroke diet protocol?
Do you HAVE A DIET PROTOCOL? Does your doctor know one damn thing about your recovery and prevention of your next stroke and dementia? Why is your doctor ignoring all this research and not demanding you consume coffee? Stupidity? Ignorance? Don't give a damn about research after medical school?

Like Your Coffee Black? Congratulations, You Could Be a Psychopath

How A Cup Of Coffee May Help People Manage Stress, Avoid Depression And Memory Loss 

Usual dose of caffeine has a positive effect on somatosensory related postural stability in hemiparetic stroke patients

Coffee May Lower Your Risk of Dementia 

Good News: Coffee Could Be Cleaning Out Your Arteries.

How coffee protects against Parkinson’s

Consuming one cup of coffee per day can decrease stroke risk by up to 20%.

Study confirms coffee can make you happy

“It is inhumane, in my opinion, to force people who have a genuine medical need for coffee to wait in line behind people who apparently view it as some kind of recreational activity.” Dave Barry

Does More Coffee Mean Less Arterial Plaque? -Arterial calcium lowest in healthy Korean adults with moderate-to-heavy coffee habits.

The latest here:

Coffee associated with colon cancer survival

Patients are actually customers … Who knew?

And with only a 10% full recovery rate, why are any stroke clinics and hospitals still in business? Because they don't tell you how badly their ability to treat stroke is.
Why they are so f*cking bad? And the stupid comment, 'All strokes are different, all stroke recoveries are different', is ignorance and laziness personified. Start screaming in their faces.
http://medcitynews.com/2014/04/patients-actually-customers-knew/?utm_source=MedCity+News+Subscribers&

Agnotology - the cultural production of ignorance

Who is going to study the cultural ignorance in the stroke world? There are tons of examples.

Cultural production of ignorance provides rich field for study

Agnotology - A Missing Term to Describe the Cultural

Production of Ignorance (and Its Study)

Are you ignorant or uninformed about stroke?

What about your doctor and therapists?
Ignorant:

lacking knowledge or awareness in general; uneducated or unsophisticated.

"he was told constantly that he was ignorant and stupid"

synonyms:

uneducated, unknowledgeable, untaught, unschooled, untutored, untrained, illiterate, unlettered, unlearned, unread, uninformed, unenlightened, benighted;

Uninformed:

not having or showing awareness or understanding of the facts.

"uninformed criticism of conservation projects"

synonyms:

unenlightened, uneducated, unknowledgeable, untaught, unlearned, unread, ignorant

What will it take for your stroke world to become informed and helpful to your recovery?
Seth Godin always has great commentary on subjects;
http://sethgodin.typepad.com/seths_blog/2014/02/uninformed-or-ignorant.html

Whom would you go to for the best information on stroke recovery? Put that in the comments.

Stuart Firestein: The pursuit of ignorance

We have one hell of a lot of willful ignorance in the stroke world. That is not a good thing. But watch this TED talk anyway.
http://www.ted.com/talks/stuart_firestein_the_pursuit_of_ignorance.html?utm_source=newsletter_daily&utm_campaign=daily&utm_medium=email&utm_content=button__2013-09-24

Ignorance in stroke rehab

I've been reading a great book, Ignorance by Stuart Firestein
One of the better lines is that when scientists get together at seminars they don't discuss the latest and greatest pieces of knowledge - they discuss what hasn't been discovered yet.

Working scientists don’t get bogged down in factual swamps, he says, because they don’t care all that much for facts. Facts are not what science is all about. It’s only when the facts fail that scientists really put on their thinking caps.

Scientists, Dr. Firestein says, are driven by ignorance.

In this sense, ignorance is not stupidity. Rather, it is a particular condition of knowledge: the absence of fact, understanding, insight or clarity about something. It is a case where data don’t exist, or more commonly, where the existing data don’t make sense.

He teaches a course at Columbia called SNC3429 Ignorance. Do you want an A or an F in that course?

And boy do we have a lot of ignorance in stroke rehab and research.

Who is going to change that? Your doctor?

Your stroke associations, WSO? Don't make me laugh, You are going to change that by demanding that all the medical staff you are in contact with come up with answers to their ignorance.