Pretty much useless they give you NO INFORMATION on how much watermelon juice or pomelit to drink to remove such plaque. 10 years to come up with an answer and NO ONE DID A DAMN THING.
Watermelon juice reverses hardening of the arteries Nov. 2011
Another here:
Hebrew University Researcher Finds 'Sweet' Way To Help Prevent Heart Disease, fruit known in Hebrew as pomelit December 2004
Subclinical Atherosclerosis and BrainMetabolism in Middle-Aged Individuals
The PESA Study
Marta Cortes-Canteli, , t,a,
* Juan Domingo Gispert, PHD,b,c,d,e,
* Gemma Salvadó, MSC,
b,c
Raquel Toribio-Fernandez, PHD,a Catarina Tristão-Pereira, MSC,
a Carles Falcon, PHD,b,d Belen Oliva, MSC,
a
Jose Mendiguren, MD,f Leticia Fernandez-Friera, MD, PHD,a,g,h Javier Sanz, MD,a,i Jose M. Garcia-Ruiz, MD,a,h,j
Antonio Fernandez-Ortiz, MD, PHD,a,h,k Javier Sanchez-Gonzalez, PHD,l Borja Ibanez, MD, PHD,a,h,m
José Luis Molinuevo, MD, PHD,b,c,e,n,
y Valentin Fuster, MD, PHDa,i,
y
Marta Cortes-Canteli, , t,a,
* Juan Domingo Gispert, PHD,b,c,d,e,
* Gemma Salvadó, MSC,
b,c
Raquel Toribio-Fernandez, PHD,a Catarina Tristão-Pereira, MSC,
a Carles Falcon, PHD,b,d Belen Oliva, MSC,
a
Jose Mendiguren, MD,f Leticia Fernandez-Friera, MD, PHD,a,g,h Javier Sanz, MD,a,i Jose M. Garcia-Ruiz, MD,a,h,j
Antonio Fernandez-Ortiz, MD, PHD,a,h,k Javier Sanchez-Gonzalez, PHD,l Borja Ibanez, MD, PHD,a,h,m
José Luis Molinuevo, MD, PHD,b,c,e,n,
y Valentin Fuster, MD, PHDa,i,
y
ABSTRACT
BACKGROUNDAtherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular
risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains unexplored.
risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains unexplored.
OBJECTIVES
This study sought to determine the association between brain metabolism, subclinical atherosclerosis,
and CVRFs in middle-aged asymptomatic individuals.
and CVRFs in middle-aged asymptomatic individuals.
METHODS
This study included 547 asymptomatic middle-aged participants (50 4 years, 82% men) from the PESA
(Progression of Early Subclinical Atherosclerosis) study with evidence of subclinical atherosclerosis. Participants underwent 18F-fluorodeoxyglucose (FDG)-positron emission tomography. Global brain FDG uptake and voxel-wise analyses
were used to evaluate the associations of cerebral metabolism with CVRFs and atherosclerotic plaque burden in carotids
and femorals assessed by 3-dimensional vascular ultrasound.
RESULTS
(Progression of Early Subclinical Atherosclerosis) study with evidence of subclinical atherosclerosis. Participants underwent 18F-fluorodeoxyglucose (FDG)-positron emission tomography. Global brain FDG uptake and voxel-wise analyses
were used to evaluate the associations of cerebral metabolism with CVRFs and atherosclerotic plaque burden in carotids
and femorals assessed by 3-dimensional vascular ultrasound.
RESULTS
Global FDG uptake showed an inverse correlation with 30-year Framingham Risk Score (FRS) (b ¼ 0.15,p < 0.001). This association was mainly driven by the presence of hypertension (d ¼ 0.36, p < 0.001). Carotid plaque burden was inversely associated with global brain FDG uptake (b ¼ 0.16, p < 0.001), even after adjusting for 30-year FRS. Voxel-wise approaches revealed that the brain areas most strongly affected by hypometabolism in association with 30-year FRS, hypertension, and carotid plaque burden were parietotemporal regions (angular, supramarginal, and inferior/middle temporal gyri) and the cingulate gyrus.
CONCLUSIONS
In asymptomatic middle-aged individuals, cardiovascular risk is associated with brain hypometabolism,
with hypertension being the modifiable CVRF showing the strongest association. Subclinical carotid plaque burden is also
linked to reduced brain metabolism independently of CVRFs. Cerebral areas showing hypometabolism include those known
to be affected in dementia. These data reinforce the need to control CVRFs early in life in order to potentially reduce the
brain’s midlife vulnerability to future cognitive dysfunction.
with hypertension being the modifiable CVRF showing the strongest association. Subclinical carotid plaque burden is also
linked to reduced brain metabolism independently of CVRFs. Cerebral areas showing hypometabolism include those known
to be affected in dementia. These data reinforce the need to control CVRFs early in life in order to potentially reduce the
brain’s midlife vulnerability to future cognitive dysfunction.
(J Am Coll Cardiol 2021;77:888–98)
© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open
access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open
access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
