The Top 10 Longevity Articles That Defined 2025 by Super Age

 I'm going to get there.

The Top 10 Longevity Articles That Defined 2025

Higher lean muscle mass may offer protection against Alzheimer's disease

Well your doctor should already be testing for this and have protocols to reduce it to lean muscle mass. That will probably require getting you 100% recovered so you can do aerobic exercises.

Level of fat within the body's muscle may lead to risk of cognitive decline while aging

The latest here:

Higher lean muscle mass may offer protection against Alzheimer's disease

Reviewed by Megan Craig, M.Sc.Jun 29 2023

High levels of lean muscle might protect against Alzheimer's disease, suggests a large study published in the open access journal BMJ Medicine. But further research is needed to tease out the underlying biological pathways, along with the clinical and public health implications, say the study authors.

Obesity has been associated with a heightened risk of Alzheimer's disease in numerous studies, possibly explained by the attendant increased inflammation, insulin resistance, and higher levels in fat tissue of the protein harmful to brain health, amyloid β.

Lower levels of lean muscle have also been associated with a heightened risk of the disease, but it's not clear if this might precede or succeed a diagnosis.

To try and find out, the researchers used Mendelian randomization, a technique that uses genetic variants as proxies for a particular risk factor-;in this case lean muscle-;to obtain genetic evidence in support of a particular outcome-;in this study, Alzheimer's disease risk.

They drew on 450, 243 UK Biobank participants; an independent sample of 21,982 people with, and 41,944 people without, Alzheimer's disease; a further sample of 7329 people with, and 252,879 people without, Alzheimer's disease to validate the findings; and 269,867 people taking part in a genes and intelligence study.

Bioimpedance-;an electric current that flows at different rates through the body depending on its composition-;was used to estimate lean muscle and fat tissue in the arms and legs, the results of which were adjusted for age, sex, and genetic ancestry.

Some 584 genetic variants were associated with lean muscle mass; none was located in the APOE gene region that is associated with vulnerability to Alzheimer's disease. These genetic variants combined explained 10% of the difference in lean muscle mass in the arms and legs of the study participants.

On average, higher (genetically proxied) lean muscle mass was associated with a modest, but statistically robust, reduction in Alzheimer's disease risk.

This finding was replicated in the further sample of 7329 people with, and 252,879 people without, Alzheimer's disease, using different measures of lean muscle mass-;trunk and whole body.

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Lean mass was also associated with better performance on cognitive tasks, but this association didn't explain the protective effect of lean mass on Alzheimer's disease risk.

Nor was body fat, adjusted for lean mass, associated with the risk of Alzheimer's disease, but it was associated with poorer cognitive task performance.

"These analyses provide new evidence supporting a cause-and-effect relation between lean mass and risk of Alzheimer's disease," say the researchers.

The findings also "refute a large effect of fat mass on the risk of Alzheimer's disease and highlight the importance of distinguishing between lean mass and fat mass when investigating the effect of adiposity measures on health outcomes," they add.

But they caution: "Our findings need to be replicated with independent lines of complementary evidence before informing public health or clinical practice. Also, more work is needed to determine the cut-off values for age and degree of pathology of Alzheimer's disease after which modifications of lean mass might no longer reduce the risk."

Nor is it clear whether increasing lean mass could reverse the pathology of Alzheimer's disease in patients with preclinical disease or mild cognitive impairment, they add.

But they conclude that if future studies back their findings, "public health efforts to shift the population distribution of lean mass, potentially through campaigns to promote exercise and physical activity, might reduce the population burden of Alzheimer's disease."

Source:

BMJ

Journal reference:

Daghlas, I., et al. (2023) Genetically proxied lean mass and risk of Alzheimer's disease: mendelian randomisation study. BMJ Medicine. doi.org/10.1136/bmjmed-2022-000354.

Predictive ability of hand-grip strength and muscle mass on functional prognosis in stroke rehabilitation patients

 

But you're not predicting recovery, you're predicting failure to recover. SOLVE THE FUCKING 100% RECOVERY PROBLEM. SURVIVORS WANT NOTHING LESS.

Predictive ability of hand-grip strength and muscle mass on functional prognosis in stroke rehabilitation patients

Author links open overlay panelTatsuyaMatsushita

ShintaNishiokaPh.D.AnnaYamanouchiYukaOkazakiKanaOishiRyuseiNakashimaYoshiharuTokunagaM.D., Ph. D.ShinyaOnizukaM.D., Ph. D.

https://doi.org/10.1016/j.nut.2022.111724Get rights and content

Highlights

•

Hand-grip strength independently predicted functional outcomes in stroke patients.

•

Adjusted skeletal muscle mass index did not show the relationship with the outcome.

•

The cutoff value of hand-grip strength for returning home was 15.1 kg for males.

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For females, 9.5 kg was the cutoff value of hand-grip strength for returning home.

Abstract

Objective

: To investigate the association of muscle strength and adjusted appendicular skeletal muscle mass (ASM) with the Functional Independence Measure (FIM) and the probability of returning home in stroke patients.

Research Methods & Procedure

: A retrospective cohort study was conducted for older stroke patients admitted to convalescent rehabilitation wards between January 2017 and October 2020. Hand-grip strength (HGS) was used to assess muscle strength. ASM was measured by bioelectrical impedance analysis and then divided by height-squared, body weight, body mass index, body fat mass, and body fat percentage to calculate the adjusted ASM. The primary outcome was FIM at discharge and the secondary outcome was the probability of returning home. Multivariate analyses were conducted to adjust confounding effects.

Results

: The data of 699 participants (female, 47%; median age, 79 years) were analyzed. HGS was independently associated with FIM at discharge in males (partial regression coefficient [B] = 0.482; 95% confidence interval [CI] = 0.225–0.740) and females (B = 0.664; 95% CI = 0.263–1.065) and with returning home in males (odds ratio [OR] = 1.070; 95% CI = 1.030–1.100) and females (OR = 1.070 [95% CI = 1.000–1.130). Conversely, none of the adjusted ASM indices were associated with the outcomes. The cutoff value of HGS for returning home was 15.1 kg for males and 9.5 kg for females

Conclusions

: HGS independently predicted FIM at discharge and the probability of returning home(Not good enough! Are you even measuring 100% recovery?  No, then you are OK with failure! Survivors aren't!) in stroke patients. The adjusted ASM methods had less predictive value for functional and discharge outcomes.

 

Is there sufficient evidence to supplement omega-3 fatty acids to increase muscle mass and strength in young and older adults?

What is your doctors' prescription to stop your muscle atrophy? ANYTHING AT ALL? Or head in the sand behavior by your doctor?

Maybe something in  these muscle atrophy posts?

• muscle atrophy (12)

  For each day a patient is in hospital lying in bed with minimal activity approximately 13% of muscular strength is lost (Ellis, Jackson, Liu, Molloy, & Paterson, 2013).

 

I have 69 posts on Omega-3s with lots of benefits. Ask your doctor for an analysis. Followup needed which will never occur since we have NO STROKE LEADERSHIP to go to for anything.

 

Is there sufficient evidence to supplement omega-3 fatty acids to increase muscle mass and strength in young and older adults?

Author links open overlay panelLuana T.Rossato^aBrad J.Schoenfeld^bErick P.de Oliveira^a

https://doi.org/10.1016/j.clnu.2019.01.001Get rights and content

Summary

Omega-3 (ω-3) is a polyunsaturated fatty acid with anti-inflammatory properties that presents three main forms: alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid. Recently, studies performed in both young and older adults suggest that ω-3 may improve gains in muscle mass and/or enhance physical function. Thus, the aim of this narrative review was to evaluate the current evidence of ω-3 intake/supplementation on muscle/lean mass (LM) and physical function in young and older adults, and draw research-based conclusions as to the practical implications of findings. We first assessed whether ω-3 intake is associated with muscle mass and strength (observational studies), and then sought to determine whether evidence shows that supplementation of ω-3 increases muscle protein synthesis, LM and strength in adults and older adults (interventional studies). The search was carried out in PubMed and Scopus databases for the periods between 1997 and November 2018. The following keywords were used alone and in combination: ω-3, fish oil, muscle protein synthesis, muscle mass, lean mass, body composition, and physical function. In general, ω-3 supplementation does not seem to promote increases in muscle mass in sedentary young and older adults; the hypertrophic effects of supplementation when combined with resistance training remain equivocal. Moreover, there is conflicting evidence as to whether supplementation confers a beneficial effect on muscle function in older adults. Importantly, this conclusion is based on limited data and more studies are needed before ω-3 supplementation can be recommended as a viable strategy for such purposes in clinical practice.

Keywords

Omega-3

Muscle protein synthesis

Muscle mass

Lean mass

Physical function

© 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Muscle Mass Should Be a New Vital Sign, Research Shows

Your doctor will need to get you 100% recovered so as not to get muscle atrophy and lose muscle mass. DEMAND THAT!

Muscle Mass Should Be a New Vital Sign, Research Shows

A comprehensive review published in Annals of Medicine confirms low muscle mass is linked to an increased risk of serious health complications and decreased survival.
Growing scientific evidence suggests muscle mass should be a key factor in evaluating a person’s health status, especially if living with a chronic disease
The results of the current study confirm the critical role muscle mass plays in health with studies demonstrating that people with less muscle had more surgical and post-operative complications, longer hospital stays, lower physical function, poorer quality of life, and overall lower survival.
The review examined the latest research over the course of a year (January 2016-January 2017) including more than 140 studies in inpatient, outpatient, and long-term care settings, and had 1 resounding conclusion: muscle mass matters.
The data show muscle mass can say a lot about a person’s overall health status, especially if living with a chronic disease. Results showed that:
● Women with breast cancer who had more muscle had a nearly 60% better chance of survival.
● Patients in the intensive care unit (ICU) with more muscle spend less time on the ventilator -- as well as less time in the ICU -- and have a better chance of survival.
● People with chronic obstructive pulmonary disease who have more muscle experience better respiratory outcomes and lower occurrence of osteopenia or osteoporosis.
● In the long-term care setting, individuals with lower muscle mass had more severe Alzheimer’s disease.
“Muscle mass should be looked at as a new vital sign,” said Carla Prado, PhD, University of Alberta, Edmonton, Alberta. “If healthcare professionals identify and treat low muscle mass, they can significantly improve their patients’ health outcomes. Fortunately, advances in technology are making it easier for practitioners to measure muscle mass.”
Reference: http://dx.doi.org/10.1080/07853890.2018.1511918
SOURCE: Abbott

Only 20 minutes less sitting per day is enough to maintain good health and muscle mass

Will your doctors let you know of this study and setup a protocol to accomplish this for you? 

• 69 percent sedentary time (1 post to August 2019)

Only 20 minutes less sitting per day is enough to maintain good health and muscle mass 

30 August 2017 University of Jyväskylä

Finnish researchers conducted one of the largest and longest studies to find out if it is possible to reduce sedentary time and if the reduction will result in any health benefits during one year. A tailored counseling helped busy office workers with young children to decrease their sedentary leisure time 21 minutes per day, which was enough to improve some biomarkers and to maintain muscle mass during one year.
A total of 133 office workers with young children participated in the study conducted at the University of Jyväskylä, Finland. The participants were randomized in two groups. The participants of the intervention group were provided with tailored counseling in order to discuss strategies to reduce sitting at work and leisure time. The participants set personal goals that they found feasible for the everyday lives of their families. The most common goal for work time was to break up sitting periods while working and at coffee breaks. For leisure time, the most common goals were active commuting and an increase in active time with the family.
At the baseline, the participants were sedentary (assessed objectively by accelerometers) for 5.6 hours per day at work, and 3.8 hours per day during leisure time. After the counseling session, sedentary leisure time decreased by 21 minutes per day while light activity and breaks in sedentary time increased. At the end of the year, the intervention group still had 8 minutes less sedentary leisure time, whereas that of the control group tended to increase slightly. Women, but not men, were able to increase light activity time and breaks in sitting also at work.
Several health markers were monitored during the one-year period. After the counseling session, the intervention group’s fasting glucose levels decreased slightly. The Apolipoprotein B-to-Apolipoprotein A-1 ratio, which is a novel biomarker of cholesterol transport capacity and related to cardiovascular risk, improved during the year. At the same time, leg muscle mass was maintained in the intervention groups, whereas the control group’s muscle mass decreased by a half percent.
The first author, Doctor of Sport Sciences Arto Pesola finds the results preliminary but promising:
– This study shows that it is possible to reduce the sedentary time of people in a busy phase of life. Even though the effect of tailored counseling diluted during the year, the intervention was effective in preventing an increase in sitting. This is important, because sedentary time tends to increase while we age. The effect was most visible during leisure time, where the sedentary time was already lower. This may reflect the demands of working life and that counseling targeted at individuals and their families is ineffective in changing the sitting time at work, at least in men. Instead, people may find more opportunities and freedom to reduce sedentary time and to participate in enjoyable family activities out of working hours. Parents may think at first that spending time with their children is away from their own physical exercise. However, that way they can reduce sitting time and show a good example to their offspring about a physically active lifestyle. This is motivating, and as shown in the study, may be beneficial for health in the long run.
Epidemiological studies have shown that increased sitting time is associated with type 2 diabetes, cardiovascular diseases and premature mortality.
The present study was among the first ones to show that it is possible to reduce sedentary time and that even a small decrease in sedentary time can be beneficial for initially healthy people. Reductions in sedentary time may be easier to achieve when they are incorporated in common family activities and other everyday tasks during leisure time. Future studies should investigate if it would be possible to reduce sitting at work by changing the physical or social environment, and what are the physiological mechanisms that explain the health benefits of reduced sitting time.
The study was part of the InPACT project led by Professor Taija Juutinen Finni and funded by the Finnish Ministry of Education and Culture. Other financers were the Juho Vainio Foundation, the Yrjö Jahnsson Foundation and the Ellen and Artturi Nyyssönen Foundation.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183299

• Full bibliographic informationThe original paper was published in the PLOS ONE journal on 24 August 2017:
  Arto J. Pesola, Arto Laukkanen, Risto Heikkinen, Sarianna Sipilä, Arja Sääkslahti, Taija Finni. Accelerometer-assessed sedentary work, leisure time and cardio-metabolic biomarkers during one year: effectiveness of a cluster randomized controlled trial in parents with a sedentary occupation and young children.

Preserve your muscle mass

What protocol are you following to prevent atrophy and gain muscle mass? Does your doctor even know about this?
http://www.health.harvard.edu/staying-healthy/preserve-your-muscle-mass?

Age-related muscle loss, called sarcopenia, is a natural part of aging. After age 30, you begin to lose as much as 3% to 5% per decade. Most men will lose about 30% of their muscle mass during their lifetimes.

More at link.

The 6 Rules of Gaining Muscle Mass - stroke rehab needs

What protocol are you following to prevent atrophy and gain muscle mass?

The 6 Rules of Gaining Muscle Mass - stroke rehab needs

RULE #1: Eat More Calories Than You Burn
RULE #2: Double or Triple Your Protein Intake
RULE #3: Eat Mostly Nutrient-Dense Whole Foods
RULE #4: Do Compound Exercises in The Gym
RULE #5: Lift Heavier Weights
RULE #6: Get 7+ Hours of Sleep Every Night

Details at link.