Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 34,483 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there. Did your doctor somehow miss the recovery protocol that Pedro Bach-y-Rita used to recover fully back in 1958 with only a partial brain?
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Cross-sectional
age-skill profiles suggest that cognitive skills start declining by age
30 if not earlier. If accurate, such age-driven skill losses pose a
major threat to the human capital of societies with rapidly aging
populations. We estimate actual age-skill profiles from individual
changes in literacy and numeracy skills at different ages. We use the
unique German longitudinal component of the Programme of the
International Assessment of Adult Competencies (PIAAC-L) that retested a
large representative sample of adults after 3.5 years. Our empirical
approach separates age from cohort effects and corrects for measurement
error from reversion to the mean. Two main results emerge. First,
average skills increase strongly into the forties before decreasing
slightly in literacy and more strongly in numeracy. Second, skills
decline at older ages only for those with below-average skill usage.
White-collar and higher-educated workers with above-average usage show
increasing skills even beyond their forties. Women have larger skill
losses at older age, particularly in numeracy.
INTRODUCTION
The commonly accepted conclusion that cognitive skills decline with age starting rather early in adult life (1)
has increasingly important potential economic implications. Cognitive
skills measured by literacy and numeracy are closely related to
individual earnings (2–4) and national growth rates (5, 6), implying that the steady and marked changes in the age composition of societies (7)
might directly affect the economic well-being of nations. However, this
assumed skill pattern has largely come from cross-sectional data that
necessarily incorporate not only aging patterns but also cohort
differences in skills. If the negative age pattern is simply due to
conflating age and cohort effects, the economic concerns are
considerably lessened. Recently developed individual longitudinal skill
tests for a representative population of adults allow us to provide
evidence on actual changes in skills with age and on their relationship
with adult skill usage.
We study the
inevitability of age-driven skill decline using exceptional longitudinal
data for the German adult population. Administered by the Organization
for Economic Co-operation and Development (OECD), the Programme for the
International Assessment of Adult Competencies (PIAAC) tested literacy
and numeracy skills that are relevant for participation in social life
and work, and surveyed economic and social conditions for random samples
of the population aged 16 to 65 in 39 countries (8).
Germany, unique among all participating countries, created a panel of
participants from the PIAAC sample who were re-surveyed and retested 3.5
years after the original survey.
We use the
panel dimension of the data to estimate credible average age-skill
profiles for the adult population. Observing actual changes in adult
skills over the full age spectrum allows us to break the confounding of
age and cohort patterns that has been ubiquitous in general
cross-sectional analyses of adult skills. We estimate the average
annualized marginal changes in skills for each age and concatenate them
across individuals of different ages to derive full age-skill profiles.
However, the panel data introduce new methodological problems that must
be addressed before the analysis of age-skill patterns.
Creating
reliable age-skill patterns based on individual aging requires
addressing the bias from measurement errors that inevitably accompany
testing of skills over time. Observations of test scores include a
combination of true scores and measurement errors, leading to systematic
errors when looking at individual changes with age. Intuitively, low
observed test scores are more likely to include negative errors. When we
observe another assessment for an initially low-scoring individual, the
measurement error is unlikely to be as negative as the first time,
implying that the change in true test scores is biased upward for
low-scoring individuals. For initially high-scoring individuals, the
opposite will be true. This reversion to the mean will bias the overall
age-skill relationship when skills vary by age. Thus, we correct the
observed change in test scores throughout for reversion to the mean (9) to obtain error-adjusted age-skill patterns.
We
find that average (error-corrected) skills increase substantially into
the forties for both literacy and numeracy. Subsequently, average skills
decline slightly in literacy and strongly in numeracy. The averages,
however, mask important heterogeneity.
With
the appropriately adjusted age-skill profiles, we can further
investigate the role of skill usage. Previous analyses have considered
whether individual background or occupations influence the evolution of
age-skill patterns. These investigations of heterogeneity in age
patterns are generally motivated by assumed differences in skill usage
across groups, but data on skill usage have not typically been
available. Because the background data from the PIAAC survey provide
information on the detailed nature and frequency of participants’ skill
usage at work and at home, we are able to explore the demographic aging
patterns in greater depth.
Individuals with
above-average skill usage at work and home on average never face a skill
decline (at least until the limit of our data at age 65). Consistent
with the assumptions of prior studies, usage interacts closely with a
variety of background characteristics. Thus, both literacy and numeracy
skills keep increasing for white-collar and tertiary-educated workers in
the second half of their working life if they have above-median skill
usage, but not if skill usage is below the median. Skill evolution also
varies by gender: Women show steeper skill decline at older ages,
especially in numeracy.
The primary
contribution of our analysis to the literature on cognitive aging is the
development of rich age-skill profiles for literacy and numeracy
skills, skills which have been shown to have economic payoffs in the
labor market, using longitudinal variation in a large representative
sample. The data allow us to go beyond averages to consider important
dimensions of heterogeneity and to describe the connection of profile
differences with individual behavior and background. The studies closest
to our analysis use different large-scale representative surveys with
literacy and numeracy skills (1, 10),
but these do not track actual skill changes of individuals over time. A
parallel set of psychological and neuroscience studies offer related
estimates of age patterns and their sources, albeit for different
dimensions of skills and for nonrepresentative samples (11–16), but evidence on their relationship to the economic outcomes that motivate our work is lacking.
RESULTS
Average age-skill profiles
The starting point for our analysis comes from the cross-sectional picture of how cognitive skills vary with age. Figure 1Opens in image viewer
depicts adult literacy and numeracy skills by age in the PIAAC test for
representative population samples of all participating OECD countries
[see also (8, 17)].
In the cross section, average literacy and numeracy scores start
declining in the late twenties to early thirties. This pattern is
duplicated qualitatively for Germany, our analysis country, where
average literacy scores steadily fall from age 20, while numeracy scores
rise slightly before beginning to decline in the late thirties (fig.
S1).
Cross-sectional
association between age and skills in PIAAC (2012). Dots: Average
skills by age. Line: Quadratic fit (estimated over 21 to 65 age range).
Skills measured in SD units. Sample: 25 OECD countries with continuous
age data; full population, ages 16 to 65, weighted by sampling weights (N = 147,667). Data source: PIAAC.
However,
it is difficult to interpret these cross-sectional patterns because
they conflate age and cohort effects. Individuals across different ages
also come from different cohorts and have thus experienced different
histories of skill determinants, implying that these charts fail to
describe the true patterns of the age-skill relationship over time for
any individual. As a result, they also cannot reliably be used to
understand the factors that feed into skill changes by age without
introducing strong assumptions about the nature of cohort and individual
time patterns.
The changes in observed
numeracy and literacy skills for individuals over time show a very
different pattern than suggested by the cross-sectional data. Figure 2BOpens in image viewer
depicts the annualized marginal changes in scores with age for
individuals at each age for the full German population sample (3263
observations). The analysis corrects for reversion to the mean, and it
includes a quadratic fit and 95% confidence intervals. The quadratic
prediction indicates increases in skills for individuals up to age 45 in
literacy and up to age 40 in numeracy. Skill changes turn negative
beyond these ages, with notably stronger declines for numeracy than for
literacy. In both subjects, the marginal change in skills declines
steadily with age. Initially, this decline is close to linear but
ultimately gets flatter.
Summary: A recent study indicates that engaging in
mental acuity tasks can potentially decrease dementia risk more than
social activities or creative hobbies.
By analyzing data from
10,318 Australian adults aged 70 and above, researchers found that those
who regularly participated in literacy activities and mind-challenging
tasks were 9-11 percent less likely to develop dementia. Creative
hobbies and more passive activities, like reading, only reduced dementia
risk by 7 percent.
The study underlines the importance of active mental stimulation in reducing dementia risk in older adults.
Key Facts:
The study utilized data from over 10,000 Australian adults aged 70 and older.
Those engaging regularly in mental acuity tasks were 9-11% less likely to develop dementia.
Social activities and creative hobbies had a lesser impact on reducing dementia risk.
Source: Monash University
Computer
use, crosswords and games like chess are more strongly associated with
older people avoiding dementia than knitting, painting or socializing, a
Monash University study has found.
Published in JAMA Network Open,
the findings—some of the most robust on this topic to date—may help
older individuals and aged care professionals plan more targeted
approaches to reducing dementia risk.
In 2022, 55 million people globally lived with dementia, with 10 million new cases each year. Credit: Neuroscience News
Researchers
drew data from 10,318 Australians aged 70 and older participating in
the ASPREE project and the ALSOP (ASPREE Longitudinal Study of Older
Persons) sub-study.
They found that participants who routinely engaged in adult literacy
and mental acuity tasks such as education classes, keeping journals, and
doing crosswords were 9-11 percent less likely to develop dementia than
their peers.
Creative hobbies like crafting, knitting and
painting, and more passive activities like reading reduced the risk by 7
percent. In contrast, the size of someone’s social network and the
frequency of external outings to the cinema or restaurant were not
associated with dementia risk reduction.
The results remained
statistically significant even when adjusted for earlier education
level, and socioeconomic status. No significant variations were found
between men and women.
In 2022, 55 million people globally lived with dementia, with 10 million new cases each year.
Senior
author Associate Professor Joanne Ryan, from the School of Public
Health and Preventive Medicine, said identifying strategies to prevent
or delay dementia was a huge global priority.
“We
had a unique opportunity to close a gap in knowledge by investigating a
broad range of lifestyle enrichment activities that older adults often
undertake, and assess which of those were most strongly aligned with
avoiding dementia,” Associate Professor Ryan said.
“I think what our results tell us is that active manipulation of
previously stored knowledge may play a greater role in dementia risk
reduction than more passive recreational activities. Keeping the mind
active and challenged may be particularly important.”
The leisure activities assessed encompassed:
adult literacy activities such as adult education classes, using computers, keeping a journal
mental acuity tasks like completing quizzes and crosswords, playing cards/chess
creative hobbies like woodworking, knitting or painting
more passive activities like keeping up with the news, reading or listening to music
social network activities like meeting and interacting with friends
planned excursions such as going to a restaurant, museum or the cinema.
Associate
Professor Ryan said the results did not rule out that those naturally
drawn to the types of leisure activities linked to cognitive health also
had specific personality traits that were otherwise beneficial, or they
may generally have had better health behaviors.
“While engaging
in literacy and mental acuity activities may not be a magic pill to
avoid dementia, if that was your goal and you had to choose, our
research certainly suggests these are the activities most likely to
support prolonged good cognitive health,” she said.
Associate
Professor Ryan said social connection may also still be quite important
to cognitive health and mental well-being, even though it did not show a
clear link with dementia risk in the study.
“The participants
were cognitively healthy, and were likely already leading socially
active lives, such that the cognitive benefits of strong social networks
may be less obvious in this group compared to the general public,” she
said.
About this cognition and dementia research news
Author: Joanne Ryan Source: Monash University Contact: Joanne Ryan – Monash University Image: The image is credited to Neuroscience News
I will need to work on my memory, with 19,000+ blog posts there are lots that I don't recall specifics on any more. Eg., why I started taking certain supplements. A friend's husband had a TBI and I didn't recall specifics about what I wrote about so it was all new to me again.
Started working on Ken-ken puzzles along with Sudoku again.
I wonder if this 107 year old was a super-ager or just a high functioning drunk?
When
it comes to retirement, experts recommend that everyone do some hard
thinking. By this, they mean you should plan your finances responsibly,
consider carefully where to live, and decide what colour beach chair to
sit in all day as you sip strawberry daiquiris in the sun. But there’s
another reason to think hard about these details: hard thinking by
itself – a strenuous mental workout – is good for your ageing brain.
My collaborators and I at Massachusetts General hospital and Northeastern University in Boston study people over 65
who have incredible memories for their age, on a par with healthy
25-year-olds. Scientists call them “superagers” (a term coined by neurologist Marsel Mesulam
at Northwestern University in Chicago). While nobody knows exactly why
some people are superagers, we believe that one common factor is that
they engage in demanding mental exercise. They continually challenge
themselves to learn new things outside of their comfort zone.
Beginning
in middle age, research shows, many people take steps to avoid
unpleasantness: they quit their irritating jobs; take relaxing holidays
instead of vigorous ones; they pursue happiness. Scientists call this
phenomenon the “positivity effect”.
Nobody wants a life filled with stress, so it’s reasonable to indulge
the positivity effect and divest yourself of negative things. In fact,
stress that continues for a long time, a condition known as chronic
stress, is toxic to your brain – it literally eats away at critical
brain regions.
Not all stress is bad, however. Research suggests that you need some
amount of stress in your life if you want to stay mentally sharp – in
particular, the momentary stress that comes with hard work. Your nervous
system evolved so that occasional bouts of stress, where you tax your
body and brain for a short time, is necessary to keep your brain healthy
as you age.
To understand why this is the case, consider how your memoryworks.
Whenever you remember something, like where you left your car keys, you
aren’t retrieving a memory wholesale from some distinct crevice in your
brain; instead, you construct memories in the moment, out of bits and
pieces gathered from around your brain. This construction process is
launched by an ensemble of brain regions that, according to our
research, are thicker and better connected in superagers. Perhaps you’ve
heard of some of these regions, which include the hippocampus, the
anterior insula, the midcingulate cortex, and the medial prefrontal
cortex, among others.
The same “superager ensemble” of brain regions also assembles your
thoughts, emotions, decisions, dreams, sights, sounds, smells, and
everything else you perceive, using the same construction process that
makes your memories. Anytime you feel happy or afraid, for example, your brain constructs those emotions out of bits and pieces of your past experience in similar situations, led by your brain’s superager ensemble.
In addition, the superager ensemble performs the vital task of
regulating your organs, hormones and immune system. These brain regions
are responsible for predicting your body’s energy needs in advance, to
keep you alive and healthy. If you’re getting the idea that they are
hugely important, you’re right: they are major hubs that coordinate
communication throughout your brain. They show up in thousands of
neuroscience studies on diverse topics. I’m calling them the superager
ensemble only as a convenient shorthand.
French sculptor Louise Bourgeois in her studio in New
York in 1995 – she was in her early 80s. Photograph: Porter
Gifford/Corbis via Getty Images
All in all, when the key regions of your superager ensemble are thick
and well connected, your brain can regulate your body and construct
your experiences faster and more efficiently. But it’s not always easy
to keep these regions in good shape, because they also create the
stressful feelings that you have when exerting yourself. Thinking hard
can make you feel unpleasant in the moment, just as strenuous physical
exercise can make you ache for a time. These unpleasant feelings invite
you to stop working hard. Based on research in my lab, however, if you
want to realise the brain benefits of superageing, you must push past
the momentary discomfort. In many cases, the unpleasant feeling is a
false alarm, and you actually do have the mental or physical resources
to continue exerting yourself.
What enables superagers to persevere in the face of unpleasantness?
That’s an open question, but scientists have found that if they
electrically stimulate one of the regions of the superager ensemble –
the midcingulate cortex – subjects report a feeling of motivation to overcome difficult challenges. The psychologist and author Angela Duckworth calls this feeling “grit”.
In the past, some researchers have described grit as the ability to
regulate your emotions by thinking rationally. Modern neuroscience,
however, has established that the human brain has no dedicated areas for thinking versus feeling. Our research suggests that grit is not somuch
a grand battle between cognition and emotion; it’s more the ability to
use your unpleasant feelings as fuel rather than as a reason to apply
the brakes. Superagers, and other people who regularly cultivate grit,
treat their unpleasant feeling as a signal to keep going.
So, what can you do to increase your chances of being a superager? While there are no guarantees, here are some tips.
First, engage in strenuous mental activity on a regular basis, enough
to make you feel unpleasant in the moment. Pick a topic that has always
interested you, whether it’s chemistry or gardening or sports
statistics, and dive into it until your brain hurts. Take classes that
you find challenging, or work on a project that’s difficult. Learn to
play a musical instrument, or study a foreign language. If you fail at
your task, don’t fret, just try something else. The key is to push past
the discomfort that comes with learning a new subject or skill.
The head of my daughter’s karate school, Grandmaster Joe Esposito,
has a saying about pushing past discomfort, when he speaks to his
nervous students before their black belt test: “Make your butterflies
fly in formation.” I suspect that superagers keep their butterflies
exceptionally well trained.
JRR Tolkien was in his 60s when Lord of the Rings was first published.
Second,
if you aren’t exercising regularly, begin doing so if you can. Studies
show that vigorous physical effort, again past the point of
unpleasantness, may have similar effects on your brain as hard mental
effort. The mechanisms are not yet known, but demanding exercise appears
to improve the thickness and connectivity of the same brain regions.
For example, in one study, people who exercised regularly in their 60s were more likely to be mentally fit in their 90s.
(Of course, check with your GP before beginning any new programme of
physical exercise, especially if you’re near or past retirement age.
Superageing is much less satisfying when accompanied by pulled muscles
or broken bones.)
Third, eat healthy food and get enough sleep. Several studies have
shown that a Mediterranean diet, rich in vegetables, fruits, fish and
healthy fats like olive oil, is associated with better memory, less cognitive decline, and less brain atrophy in general. Sufficient sleep is known to be important for a healthy memory, and it even clears out certain “wastes” from your brain, known as beta-amyloid plaques, that are linked to dementia.
I’ll also offer some non-advice. You may hear that you can exercise
your brain by playing sudoku and visiting “brain game” websites. These
relatively mild activities are not likely
to increase your odds of becoming a superager, because the level of
difficulty is too low. You have to work hard enough to feel the strain
of effort.(I'm sure Platinum Blonde in Sudoku is difficult enough.)
Superageing is an area of ongoing research, with important,
unanswered questions. We cannot say definitively, for example, if
superagers are born or made. We also don’t know if some people have a
head start on superageing because their superager ensemble starts out
thicker or better connected than average. What we do know is that the
regions of the superager ensemble tend to be thinner in people who have
suffered adversity, particularly as a child or adolescent.
We also know that these regions are thicker for children and
adolescents who exercise regularly. Exercise improves memory and school
performance in children and also has an effect on brain structure,
although more research is necessary to determine the exact range of
effects.
Also, damage to the superager ensemble is associated with a long list
of serious disorders, including depression, schizophrenia, autism,
dyslexia, chronic pain, chronic stress, dementia, and Parkinson’s
disease.
In other words, it’s never too early to start attending to your
superager ensemble. Just as you should save money for retirement
beginning at a young age, you can also start preserving your memory
early. (Scientists call this your “cognitive reserve”.) Don’t wait until you’re old to start saving – your future health may depend on it.
Currently, my colleagues and I are exploring whether people who
regularly push past momentary discomfort are better protected against
dementia and depression. These disorders are associated with
beta-amyloid plaques, the wastes that accumulate in your brain as you
age, especially as you head past 65. We suspect that people who seek and
tolerate challenging tasks are helping to protect their memory, even if
they have these plaques.
Judi Dench, now in her 80s, is ‘still wowing audiences in
a field that requires lots of memorisation’. Photograph: Tristram
Kenton/The Guardian
History is full of people who flourished late in life, such as Julia Child, who published her first cookbook when she was nearly 50, and Teiichi Igarashi, who climbed Mount Fuji at 99. Tolkien published The Lord of the Rings in his 60s. Artists such as Mary Delany, who created 1,700 meticulously crafted paper flowers, and Louise Bourgeois, the sculptor of the giant metal spider Maman,
did their most skilled work in their 70s and 80s. I can’t say whether
these impressive individuals are superagers, because we haven’t tested
their memory in the lab, but I wouldn’t be surprised. Personally, I
would love to test Judi Dench,
who at 82 is still wowing audiences in a field that requires lots of
memorisation. (On the other hand, a certain 70-year-old president of the
United States, who seems to change his mind every 10 minutes, is almost
certainly not a superager.)
So, if you want to stay mentally healthy into old age, don’t just
retire: rewire. Help to build up your brain circuitry through regular
sessions of vigorous effort, whether physical or mental. Keep up the
hard work, push past momentary discomfort, and have a happy
“rewirement”. • Lisa Feldman Barrett (@LFeldmanBarrett) is a University Distinguished Professor of Psychology at Northeastern University and the author of How Emotions are Made: The Secret Life of the Brain. To order a copy for £16.14 go to bookshop.theguardian.com or call 0330 333 6846