Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there. Did your doctor somehow miss the recovery protocol that Pedro Bach-y-Rita used to recover fully back in 1958 with only a partial brain?

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label selenium. Show all posts
Showing posts with label selenium. Show all posts

Sunday, October 25, 2026

Things Your Body Needs as You Age

 Useless, no amounts! And your incompetent? doctor won't know anything SPECIFIC either! You're screwed!

Things Your Body Needs as You Age

Calcium

With age, you can start to lose more of this mineral than you absorb. That can make your bones break more easily (osteoporosis), especially for women after menopause. Calcium helps your muscles, nerves, cells, and blood vessels work right. You get most of it from your bones, which get it from food. Women over 50 and men over 70 should get about 20% more than other adults. Milk, yogurt, and cheese are good sources.

Vitamin B12
2 / 14

Vitamin B12

It helps make blood and nerve cells. You get it naturally from animal foods like meat, fish, eggs, and dairy. Pills, shots, and “B12-fortified” foods, like breakfast cereal, are other sources. Most Americans eat enough, but age can change that. Up to 30% of people over 50 have atrophic gastritis, which makes it harder for your body to absorb it from foods. Antacids, some meds, and weight loss surgery can contribute to a lack of B12.

Vitamin D
3 / 14

Vitamin D

Your body needs it to absorb calcium. So take them in tandem to help prevent osteoporosis. Vitamin D also helps your muscles, nerves, and immune system work right. Most people get some vitamin D from sunlight. But your body is less able to convert sun’s rays to vitamin D as you age. It’s harder to get this vitamin from foods, but fatty fish like salmon, mackerel, and sardines are a good source.

Vitamin B6
4 / 14

Vitamin B6

Your body uses it to fight germs and to make energy. It also helps babies’ brains grow. You need more B6 as you get older. Some studies have found links between high B6 blood levels in seniors and better memory. But the vitamin doesn’t seem to improve mental abilities in people with dementia. Chickpeas are an easy and inexpensive source. So are liver, fatty fish and fortified breakfast cereals.

Magnesium
5 / 14

Magnesium

It helps your body make protein and bone, and it keeps your blood sugar stable. You can get it from nuts, seeds, and leafy greens. But older people tend to eat less of it. Plus, they're more likely to have long-term health conditions or take many medications, both of which may leave you short of magnesium.

Probiotics
6 / 14

Probiotics

These “friendly” bacteria are good for your gut. You get them from fermented foods like yogurt or sauerkraut, or from supplements. They can help with digestive issues like diarrhea or irritable bowel syndrome, and may even protect against allergies. Probiotics are likely safe if you’re healthy. But talk to your doctor first if you have any medical issues or a weakened immune system.

Omega-3s
7 / 14

Omega-3s

But this: In April, another study found that adults 55 and older taking omega-3 supplements showed greater cognitive deterioration over time than nonusers. From this research: 

Why scientists are starting to worry popular supplements could harm the aging brain

These fatty acids are called “essential” because your body can’t make them. They’re important for your eyes, brain, and sperm cells. They also could help protect against age-related disease like Alzheimer’s, arthritis, and macular degeneration, which can cause blindness. Unless your doctor says otherwise, it’s best to get your omega-3s from food like fatty fish, walnuts, canola oil, or flaxseed.

Zinc
8 / 14

Zinc

Many American seniors don’t get enough of this underappreciated micronutrient. It helps your sense of smell and taste, and fights infections and inflammation -- all important jobs in older bodies. Zinc also may protect your vision. Oysters are far and away the best source of this mineral. Otherwise, you can get it from beef, crab, and fortified breakfast cereals.

Selenium
9 / 14

Selenium

It protects your cells from damage and infection, and keeps your thyroid working the right way. Selenium also can keep your muscles strong, and may help prevent age-linked illnesses like dementia, some types of cancer, and thyroid disease. Just one or two Brazil nuts a day should be enough. Don’t overdo it. Too much selenium can make your hair fall out and turn your nails brittle.

Potassium
10 / 14

Potassium

Potassium plays a part in almost everything inside your body, including your heart, kidneys, muscles, and nerves. It also may help protect against stroke, high blood pressure, and osteoporosis. Many Americans don’t get enough. Dried apricots, bananas, spinach, milk, and yogurt are good sources. Ask your doctor before you take supplements. They can interfere with medications for high blood pressure, migraine, and other conditions.

Folate
11 / 14

Folate

This natural form of vitamin B9 is in leafy greens, nuts, beans, and other foods. Pregnant women take a lab-made form of vitamin B9 called folic acid to help prevent birth defects. Folate helps with cell growth and may protect against stroke and certain cancers. Most Americans get enough. Folate found in foods is safe. But too much folic acid from supplements or fortified foods can raise your odds of having colon cancer or nerve damage.

Fiber
12 / 14

Fiber

You probably know fiber is good for you. But did you know it’s even more important as you age? Fiber helps protect against strokes, helps you poop more regularly, and lowers your cholesterol and blood sugar -- big benefits in older bodies. Women over 50 should get at least 21 grams a day, while men need 30 grams, but most people don’t get that much. That’s equal to about 6-8 servings of whole grains, or 8-10 servings of vegetables.

Where to Get Them
13 / 14

Where to Get Them

Whether it’s vitamins, minerals, or fiber, it’s best to get them from foods instead of pills. But that can be a challenge for some older Americans, especially if you don’t eat a balanced diet. You’re most likely to lack vitamin D, potassium, calcium, or dietary fiber. If you think you need more than you can get from food, talk to your doctor about supplements that will be safe with your meds, diet, and health.

Multivitamins
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Multivitamins

There’s little, if any, proof that multivitamins benefit seniors who are otherwise healthy. The U.S. Preventive Services Task Force recommends against daily multivitamins to ward off cancer or heart disease. Multivitamins marketed at seniors may be tailored with higher doses of vitamins D or B12 or less iron. But unless you have a poor appetite or have conditions that keep you from eating a healthy diet, you probably don’t need them.

Sunday, September 27, 2026

Colorectal Cancer Protective Effects and the Dietary Micronutrients Folate, Methionine, Vitamins B6, B12, C, E, Selenium, and Lycopene

 Mainly for me to keep track of this information, One friend has stage 2 colon cancer and another has stage 4.

Colorectal Cancer Protective Effects and the Dietary Micronutrients Folate, Methionine, Vitamins B6, B12, C, E, Selenium, and Lycopene

Pages 11-21 | Published online: 18 Nov 2009

Abstract

Abstract: The data reported here were obtained from the case-control arm of a large, comprehensive, population-based investigation of colorectal cancer incidence, etiology, and survival, the Melbourne Colorectal Cancer Study, conducted in Melbourne, Australia. This part of the case-control study was designed to identify dietary factors associated with colorectal cancer risk in 715 incident cases compared with 727 age/sex frequency-matched randomly chosen community controls, in which a quantitative assessment of all foods eaten was made. New data are presented on the potential of two groups of micronutrients as protective agents, namely, those involved in DNA methylation, synthesis, and repair (folate, methionine, and vitamins B6 and B12) and those with antioxidant properties (selenium, vitamins E and C, and lycopene). The adjusted odds ratios showed that for folate there was significant protection for rectal cancer in second and third quintiles of consumption but not for colon cancer, and this was similar for methionine consumption. Vitamin B6 consumption was significantly protective for both colon and rectal cancer at the higher quintiles, and this was similar for vitamin B12. Dietary selenium was significantly protective at middle quintiles of consumption at both cancer sites. Dietary vitamins E and C were statistically significantly protective for both colon and rectal cancer at all levels of consumption, and for both vitamins there was a dose-response effect of increasing protection, particularly so for colon cancer. Lycopene was not associated with colorectal cancer risk. A combined model included vitamins E, C, and B12 and selenium as micronutrients protective for colorectal cancer and folate, which, however, showed an increased risk at the highest level of consumption. These data support the proposition that a diet containing the dietary micronutrients involved in DNA methylation (folate, methionine, and vitamins B6 and B12) and some of those with antioxidant properties (selenium and vitamins E and C) may have a role to play in lowering colorectal cancer risk and also that such protection can be achieved by dietary means alone.

Wednesday, September 9, 2026

Associations between essential trace elements and Alzheimer's disease and related dementias

 Ask your doctors about the benefits of selenium and iron as described in the following posts. Then get AN EXACT PROTOCOL from them on all trace minerals.

  • selenium (15 posts to May 2015)
  • iron (13 posts to December 2012)

Associations between essential trace elements and Alzheimer's disease and related dementias


Abstract

INTRODUCTION

 Dysregulation of essential trace elements has been implicated in Alzheimer's disease (AD) pathogenesis, yet comprehensive epidemiologic evidence remains limited. We investigated associations of seven plasma essential trace elements, including manganese, iron, cobalt, copper, zinc, selenium, and molybdenum, with AD and all-cause dementia risk.

METHODS

We analyzed 1,737 participants from the National Alzheimer's Coordinating Center. Cross-sectional analyses assessed prevalent disease; longitudinal analyses evaluated incident cases among 1,101 initially dementia-free participants (median follow-up: 2.05 years). Multivariable logistic regression, Cox proportional hazards models, and quantile-based g-computation evaluated individual and mixture effects.

RESULTS

A simultaneous one-quartile increase in the seven-element mixture was associated with lower prevalent AD (odds ratio [OR] = 0.69; 95% confidence interval [CI]: 0.52–0.91). Longitudinally, higher plasma iron was associated with lower incident AD (hazard ratio [HR] = 0.41; 95% CI: 0.19–0.92, Q4 vs. Q1), while selenium predicted higher incident AD risk (HR = 2.42; 95% CI: 1.11–5.27, Q4 vs. Q1).

DISCUSSION

Lower plasma iron and higher plasma selenium were each associated with greater dementia risk, identifying iron and selenium as potentially modifiable factors for dementia prevention, especially in selenium-replete populations.

Highlights

  • Higher plasma iron consistently associated with lower dementia risk.

  • Plasma selenium paradoxically linked to higher incident Alzheimer's disease (AD) risk.

  • Seven-element mixture associated with 30% lower odds of prevalent AD.(Your competent? doctor needs to create AN EXAXT PROTOCOL for these! Can't do that? PURE INCOMPETENCE!)

Thursday, October 9, 2025

Safety and efficacy of selenium in improving the outcomes of stroke patients: a systematic review and meta-analysis with GRADE system

 Let's see how much earlier research there is on selenium and the incompetence of your doctor in not doing something with it!

Here is how long your doctor has been incompetent! Call the president and ask for competent stroke medical 'professionals' to be hired.  You really should expect your 'professionals' to know more that stroke-addled me!

  • selenium (15 posts to May 2015)
  • Safety and efficacy of selenium in improving the outcomes of stroke patients: a systematic review and meta-analysis with GRADE system

      Abstract

      Background

      Stroke represents the second most common cause of death worldwide and a significant cause of long-term morbidity. Although the brain is incapable of regeneration, the element selenium (Se) has been found to have a role in regenerating the antioxidant systems and improving cell proliferation and viability. So, we conduct this systematic review and meta-analysis to assess its effectiveness in enhancing cell proliferation and viability.

      Aims

      Our study aims to determine the efficacy and safety of selenium in alleviating the impact of brain injury and promoting recovery in patients with stroke.

      Summary of review

      We finally included five randomized clinical trials. Our meta-analysis showed a statistically significant difference between selenium and placebo in the outcomes of interest: Glasgow Outcome Scale after 1 month (OR: 1.54, 95% CI [1.10, 2.15], P = 0.01) and respiratory infection (OR: 0.55, 95% CI [0.34, 0.88], P = 0.01). There is no statistically significant difference in Glasgow Outcome Scale after 3 months (OR: 1.36, 95% CI [0.97, 1.91], P = 0.07), mortality (OR: 0.76, 95% CI [0.45, 1.30], P = 0.31).

      Conclusion

      Selenium showed a promising contribution to minimizing the damage caused by brain injuries. Further studies, including randomized-controlled trials, must be conducted on the efficacy of selenium and its association with better neurological outcomes.(What about the ones I refer to above? Or don't you know about them?)

      Thursday, September 25, 2025

      Selenium and brain aging: A comprehensive review with a focus on hippocampal neurogenesis

       

      Do you really think your competent? doctor will instruct the dietician to create diet protocols on this in the hospital and for home use? I really doubt you have a functioning stroke doctor as proven by doing nothing with this! I'm doing supplements, don't know if food intake is better and how to get it. I don't have time to wait for that research which will never occur.

      Here is how long your doctor has been incompetent! Call the president and ask for competent stroke medical 'professionals' to be hired.  You really should expect your 'professionals' to know more that stroke-addled me!

    • selenium (15 posts to May 2015)
    • Selenium and brain aging: A comprehensive review with a focus on hippocampal neurogenesis


      https://doi.org/10.1016/j.arr.2025.102898Get rights and content

      Highlights

      • •
        Selenium regulates oxidative stress, neuroinflammation, and synaptic plasticity to modulate brain aging via selenoproteins.
      • •
        Selenium influences key molecular pathways (PI3K/Akt/Wnt and BDNF/TrkB) to enhance neural progenitor cell proliferation.
      • •
        The SEPP1-LRP8 axis delivers selenium to the hippocampus, and exercise enhances this system to promote neurogenesis.
      • •
        Selenium prevents ferroptosis and reduces microglial activation, promoting a healthy neurogenic environment.
      • •
        Large clinical trials and longitudinal multi-omics research are needed to confirm selenium’s role in healthy brain aging.

      Abstract

      Brain aging is accompanied by progressive cognitive decline and increased risk of neurodegenerative diseases, with adult hippocampal neurogenesis (AHN) playing a pivotal role in maintaining cognitive resilience. Selenium, an essential trace element, exerts significant neuroprotective and neurogenic effects predominantly through its incorporation into selenoproteins, which regulate oxidative stress, neuroinflammation, and synaptic plasticity. This review synthesizes recent advances delineating selenium’s metabolism, bioavailability, and its multifaceted roles in brain development, function, and aging, emphasizing mechanisms underpinning hippocampal neurogenesis. Key molecular pathways influenced by selenium include phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/Wingless/Integrated (Wnt) and brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) signaling pathways that promote neural progenitor cell proliferation and differentiation. Selenium transport via selenoprotein P and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) is critical for adequate selenium delivery to the hippocampus to support neurogenesis, with exercise demonstrated to potentiate this axis. Selenium also mitigates ferroptosis, preserves mitochondrial integrity, and modulates neuroimmune interactions by attenuating microglial activation and inflammasome signaling, fostering a neurogenic environment. Emerging evidence highlights selenium’s regulatory effects on RNA expression, including microRNAs modifications, further influencing neuronal health. Despite promising preclinical and observational data, clinical translation remains limited by heterogeneous and short-term studies. Future research priorities include multi-omics investigations, longitudinal cohorts, and addressing global selenium intake disparities through policy initiatives and precision nutrition. By consolidating mechanistic insights with clinical perspectives, this review underscores selenium’s potential as a modifiable factor to enhance AHN and cognitive health, advocating for integrated translational strategies to combat brain aging and neurodegeneration.