Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there. Did your doctor somehow miss the recovery protocol that Pedro Bach-y-Rita used to recover fully back in 1958 with only a partial brain?

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label leadership. Show all posts
Showing posts with label leadership. Show all posts

Saturday, July 11, 2020

Stroke from the Lancet

More tyranny of low expectations; 'management' NOT CURE OR 100% RECOVERY. And ignoring the really fast ways to diagnose stroke, doing this keeps neurologists employed. And yes, I know I'm criticizing a leader in stroke; but if leaders aren't leading they need to be deposed. 

 

Just maybe you want extremely fast diagnosis.

Hats off to Helmet of Hope - stroke diagnosis in 30 seconds   February 2017

 

Microwave Imaging for Brain Stroke Detection and Monitoring using High Performance Computing in 94 seconds March 2017

 

New Device Quickly Assesses Brain Bleeding in Head Injuries - 5-10 minutes April 2017

The latest here:

Stroke from the Lancet





Summary

Stroke is a major cause of death and disability globally. Diagnosis depends on clinical features and brain imaging to differentiate between ischaemic stroke and intracerebral haemorrhage. Non-contrast CT can exclude haemorrhage, but the addition of CT perfusion imaging and angiography allows a positive diagnosis of ischaemic stroke versus mimics and can identify a large vessel occlusion target for endovascular thrombectomy. Management of ischaemic stroke has greatly advanced(Really? I think it hasn't improved enough. No cures, no recovery.), with rapid reperfusion by use of intravenous thrombolysis and endovascular thrombectomy shown to reduce disability(NOT GOOD ENOUGH!). These therapies can now be applied in selected patients who present late to medical care if there is imaging evidence of salvageable brain tissue. Both haemostatic agents and surgical interventions are investigational for intracerebral haemorrhage. Prevention of recurrent stroke requires an understanding of the mechanism of stroke to target interventions, such as carotid endarterectomy, anticoagulation for atrial fibrillation, and patent foramen ovale closure. However, interventions such as lowering blood pressure, smoking cessation, and lifestyle optimisation are common to all stroke subtypes.




To read this article in full you will need to make a payment

Tuesday, March 17, 2020

Brain Injury–Mediated Neuroinflammatory Response and Alzheimer’s Disease

So WHOM is going to be contacted to drive the research that will figure out how to stop that neuroinflammation?  It is not SOMEONE ELSES PROBLEM TO SOLVE. 

Show some leadership and drive the needed research to completion.  9 months old, there should be followup occurring already.  Please report on status. 

Brain Injury–Mediated Neuroinflammatory Response and Alzheimer’s Disease 

First Published May 16, 2019 Research Article Find in PubMed
Traumatic brain injury (TBI) is a major health problem in the United States, which affects about 1.7 million people each year. Glial cells, T-cells, and mast cells perform specific protective functions in different regions of the brain for the recovery of cognitive and motor functions after central nervous system (CNS) injuries including TBI. Chronic neuroinflammatory responses resulting in neuronal death and the accompanying stress following brain injury predisposes or accelerates the onset and progression of Alzheimer’s disease (AD) in high-risk individuals. About 5.7 million Americans are currently living with AD. Immediately following brain injury, mast cells respond by releasing prestored and preactivated mediators and recruit immune cells to the CNS. Blood-brain barrier (BBB), tight junction and adherens junction proteins, neurovascular and gliovascular microstructural rearrangements, and dysfunction associated with increased trafficking of inflammatory mediators and inflammatory cells from the periphery across the BBB leads to increase in the chronic neuroinflammatory reactions following brain injury. In this review, we advance the hypothesis that neuroinflammatory responses resulting from mast cell activation along with the accompanying risk factors such as age, gender, food habits, emotional status, stress, allergic tendency, chronic inflammatory diseases, and certain drugs can accelerate brain injury-associated neuroinflammation, neurodegeneration, and AD pathogenesis.

Thursday, April 4, 2019

Genetic Variants May Influence Post-Stroke Recovery

So What? It is still the responsibility of our stroke doctors, therapists, hospitals and researchers to get all survivors 100% recovered. This will not be allowed as an excuse to not do that. Leaders solve difficult problems. ARE YOU LEADERS OR CHICKENSHITS?

Genetic Variants May Influence Post-Stroke Recovery

Genes may have a bearing not only on stroke risk, but also on how well patients recover after stroke, according to a study published in Neurology.
For the first time, researchers have identified common genetic variants that are associated with outcome after ischaemic stroke.
For the study, Martin Söderholm, MD, Lund University, Lund, Sweden, and colleagues conducted a meta-analysis of 12 international stroke studies that included 6,165 patients with ischaemic stroke.
The patients were divided into 2 groups depending on their outcome at 3 months after ischaemic stroke -- 1 group was composed of patients who died and those who were dependent on help from others to cope with activities of daily living. The other group consisted of patients who were able to cope unaided 3 months after stroke.
By comparing analyses of the patients’ genomes, the researchers were able to find several different genetic variants that appear to have played a part in the patients’ outcomes.
“One of the common genetic variants we found was significant -- that is, clearly associated with a worse outcome in the large volumes of data we were able to access,” said Annie Pedersen, University of Gothenburg, Gothenburg, Sweden.
That variation, identified as rs1842681 in the LOC105372028 gene, can be linked to another gene that is part of a major process involved in brain plasticity.
The study took into account several other factors -- age, sex, and the extent of each patient’s brain damage -- that can also affect outcome after stroke. After adjustment for these factors, the association remained between the genetic variant and elevated risk of being in the group of patients who still, 3 months after the stroke onset, were unable to manage without assistance.
“Even if 2 patients seem to have the same prospects of recovering, their outcomes can be different,” said Pederson.
“Our limited knowledge of why some patients recover well while others incur lasting functional impairments after the same type of stroke has made it difficult to develop new treatment methods,” added Christina Jern, MD, University of Gothenburg.
“In the long run, we hope the research may enable us to identify new targets for medication that might help to improve post-stroke outcome, but there is a lot of research to be done before we get there,” she concluded.
Reference: https://doi.org/10.1212/WNL.0000000000007138
SOURCE: University of Gothenburg

Friday, August 18, 2017

Congressional Heart and Stroke Caucus

You might want to ask them what leadership they are exhibiting to get all survivors 100% recovered. Not press release crapola.
Chair/Co
-
Chair(s):
Rep. Christopher H. Smith -(R) New Jersey's 4th District
Marisa Kovacs, Marisa.Kovacs@mail.house.gov, (202) 225
-
3765
Rep. Joyce Beatty -(D) 3rd District of Ohio
Kevin Carson, Kevin.Carson@mail.house.gov, (202) 225
-
4324

Sunday, February 26, 2017

Have your say on future of the district's stroke service - West Yorkshire

So contact them and demand that the goals of any stroke department is 100% recovery. Don't let them tell you it is impossible, it may be difficult but leaders tackle difficult jobs. Don't you have leaders in your stroke services? You are going to have to use the comment boxes to tell them what needs to be done but it would be much better to contact them in person.
http://www.thetelegraphandargus.co.uk/news/15117304.Have_your_say_on_future_of_the_district__39_s_stroke_service/
HEALTH watchdogs are urging people district wide to have their say over possible cuts to emergency stroke services.
Under massive NHS reorganisation plans the number of sites across West Yorkshire currently providing a critical service in the first 72 hours after a stroke, including Bradford Royal Infirmary, could be potentially reduced from five to three.
Health bosses say no decisions will be made about the future of hyper-acute stroke services until people have shared their views but the West Yorkshire and Harrogate Sustainability and Transformation Plan (STP) on how to fill a £1bn funding shortfall by 2020/2021 has said officials do “need to reduce the number of hyper-acute stroke units across West Yorkshire and Harrogate”.
That plan follows a specialist county-wide stroke services ‘blueprint’ published in June 2016 which stated that the five stroke units in West Yorkshire - at the BRI, Calderdale Royal Hospital, Harrogate and District NHS Foundation Trust, Leeds General Infirmary and Pinderfields Hospital - should be reduced to three or four.
Julie McCann who runs the Stroke Survivors Club at Cafe West in Allerton said: “It would be a really scary loss if Bradford was to lose its unit. Once again they are putting a cost on someone’s life. Time is of the essence when strokes strike, people need urgent care close by not miles way out of district.”
In summer 2015, two hyper acute stroke beds were moved from Airedale General Hospital to the BRI which meant all stroke patients across the district are cared for there in the crucial first 24 to 72 hours after a stroke. Patients from Airedale, Wharfedale and Craven are then transferred to Airedale Hospital at Steeton for further care and rehabilitation.
Now the Healthwatch group has been asked as part of the STP to find out what people think about the current stroke services that are already being provided and what would be important to them now and in the future should they have a stroke, or care for someone who has.
A spokesman said: “Healthwatch have been doing some in-depth interviews with people who’ve had recent experience of stroke. We’ve been talking with patients and carers identified through liaison with stroke rehabilitation wards at local hospitals and community stroke services. This work will contribute to the overall report for West Yorkshire and help shape the future of services across the region.”
To have your say go to surveymonkey.co.uk/r/WYStrokeServices

Monday, August 22, 2016

People often delay seeking stroke treatment, study says

So the solution is to blame the victim, rather than figuring out how to address the problem of tPA only being usable for a short time. Goddammit, you are running away from the problem. Leaders solve problems, they don't hide from them. Confront these lazy assholes. 100% recovery is the goal, regardless of when the patient comes in. That is non-negotiable. That means you need to solve the neuronal cascade of death, neuroplasticity and neurogenesis. Better get cracking. 


People often delay seeking stroke treatment, study says


While a public campaign in England has raised stroke awareness, researchers at one hospital say it is not good enough.
Despite a campaign to inform the public of stroke symptoms, as well as raise awareness of strokes overall, researchers in England say most still have limited knowledge.
Nearly two-thirds of people in a study conducted by researchers at the John Radcliffe Hospital in Oxford waited to seek treatment for a stroke, delaying care for an adverse health even that requires immediate attention to minimize its long-term effects.
Doctors and researchers have long acknowledged that every minute a stroke patient does not receive treatment -- among the most effective are clot-busting drugs which have become standard in the last several years -- lowers the doctors' ability to limit damage from the stroke, and lessens the potential for full recovery.
The Stroke Association started a campaign in 2009 in England to raise awareness of strokes in the hope people would sooner recognize whether they were having one and seek treatment.
While the National Stroke Strategy had some success, researchers say the acronym FAST, which stands for "Face Arm Speech Time" -- the order of things affected by a stroke -- may not have conveyed the most important part of the message.
"FASTER -- Face, Arm, Speech, Time, Eyes, React -- may be a better acronym for the public campaign," Dr. Ashok Handa, an assistant professor of surgery at the University of Oxford and lead author of the new study, said in a press release.
For the study, published in the British Journal of Surgery, researchers analyzed 150 patients who presented with a confirmed minor stroke between June and October 2014, analyzing the progression of their symptoms and when they sought treatment.
Nearly all the patients -- 92 percent -- delayed going to the doctor and 58.7 percent did not think they were having a stroke.
Of the patients, 34 percent had a history of stroke and 23.3 percent had undergone some type of "index" event, or basic health event that can indicate a stroke. Of the patients, 30 percent experienced a reduction or loss of vision, and none attributed the symptom to a cerebrovascular health event.
With about a third of patients unaware of the National Stroke Strategy, the researchers recommend a more rigorous, more effective public campaign to help patients recognize stroke symptoms and seek treatment with greater speed.
"Two-thirds of patients were not aware they were having a stroke, one-third were unaware of the FAST campaign and nearly one-third presented with eye symptoms," researchers write in the study. "Inclusion of eye symptoms and reaffirmation of the need to react might avoid unnecessary delays in the presentation of patients."

Saturday, June 11, 2016

Nearly All Strokes Globally Have Avoidable Element

Blaming the victim completely. This mindset allows our stroke medical 'professionals' to not bother trying to solve all the problems in stroke. Yet somehow even though almost all car crashes are preventable the medical profession still works on treating those victims and continues research to make those treatments better. A great stroke association president would not hunker behind victim blaming and would tackle BHAGs(Big Hairy Audacious Goals) 

Nearly All Strokes Globally Have Avoidable Element


Globally, stroke is almost entirely caused by modifiable risk factors, with air pollution emerging as a significant contributor, a systematic analysis showed.
Modifiable risk factors were determined responsible for 90.5% (95% uncertainty interval 88.5-92.2) of the global stroke burden, as measured using disability-adjusted life years, Valery Feigin MD, PhD, of New Zealand's Aukland University of Technology, and colleagues reported online in Lancet Neurology.
Potentially modifiable behaviors -- smoking, poor diet, and physical inactivity -- contributed to 74.2% of strokes (95% UI 70.7-76.7). Metabolic factors -- high systolic blood pressure, high body mass index (BMI), high fasting plasma glucose, high total cholesterol, and low glomerular filtration rate -- were attributable for 72.4% (95% UI 70.2-73.5).
The researchers also called attention to the "unexpectedly high" 29.2% (95% UI 28.2-29.6) of the burden of stroke attributed to air pollution.
This factor had a strong association with stroke burden in Central, Eastern, and Western sub-Saharan Africa, and South Asia, but a lower association with stroke burden in North America, most areas of Europe, Australasia, and Asia Pacific. This exemplified the variations in low- and middle- income countries and high-income countries.
"Air pollution has emerged as a significant contributor to global stroke burden, especially in low-income and middle-income countries, and therefore reducing exposure to air pollution should be one of the main priorities to reduce stroke burden in these countries," they wrote.
In an accompanying editorial, Vladimir Hachinski MD, of the University of Western Ontario in London, and Mahmoud Reza Azarpazhooh, MD, of Iran's Mashhad University of Medical Sciences, agreed, calling the percentage of strokes attributable to air pollution "alarming."
Their Global Burden of Disease Study 2013 included data from 188 countries from 1990 through 2013. Theoretical Minimum Risk Exposure Levels were used to assess levels of relevant exposures to a population for the 17 risk factors identified. Finally, the population-attributable fraction was calculated in order to determine the theoretical effect of mitigating each risk factor.
In addition to individual risk factors, clusters of risk factors were also assessed. These clusters of factors included behavioural, dietary, environmental and occupational, and metabolic categories of risk.
Notably, 71.7% of the disability-adjusted life years that were lost to stroke were in patients under 70 years of age.
The five risk factors associated with the strongest impact on disability-adjusted life years in developed countries were high systolic blood pressure, high BMI, diet low in fruits, diet low in vegetables, and smoking. The five risk factors with the strongest impact on disability-adjusted life years in developing countries were high systolic blood pressure, diet low in fruits, high BMI, diet high in sodium, and smoking.
Whereas most risk factors showed a downward trend in their contribution to stroke in high-income countries, a diet high in sugar-sweetened beverages was the exception. Over the course of the study, there was an almost 84% increase in stroke-related disability-adjusted life years from sugary drinks in high-income countries, compared with a 64% increase in its contribution globally.
Overall, the burden of risk was higher in developing countries than it was in developed countries, and almost all of the risk factors had a stronger effect on disability-adjusted life years in the low- and middle- income countries.
One limitation of the study was that atrial fibrillation, substance abuse, and some other risk factors were not assessed due to lack of data. One perplexing paradox indicated that in developing countries there was a decrease in second-hand smoke, yet an increase in tobacco smoking.
The editorial also noted that the cross-sectional, as opposed to longitudinal, study design likely led to underestimation of the global prevalence of stroke and its associated risk factors. However, it called the "monumental task" of pulling together the attributable risk data a success that "provides a firm basis for policy makers to implement preventative measures."
The work was funded by government and foundation grants.
The Stroke Riskometer app is copyrighted by the Auckland University of Technology, and funds resulting from the sale of the professional version of the app go into further research and education for stroke prevention. Support was also provided by IBM Watson Health.


My reply to this:
Who is actually solving all the problems in stroke rather than blaming the victim?
88% failure rate of tPA for full recovery.
Only 10% of patients almost fully recover.
Nothing to cure spasticity.
Nothing to cure fatigue.
Nothing on preventing the likely chance of getting dementia.
No publicly available stroke rehab protocols with efficacy percentages.
No fast and accurate way to diagnose stroke, young persons are badly diagnosed.

Tuesday, May 31, 2016

CHI Health earns award for expertise in stroke management - Kearney, NE

A great stroke association leader would be contacting these hospitals and tell them to stop putting out these false puffery articles and just focus on their factual results. But that is a pipe dream of mine.
 These are NOT result awards so they don't tell you anything about how good the program is. Call that hospital president(



Michael Schnieders
President & CEO) 


main telephone number: (308) 865-7100

  and demand to know what the RESULTS are; 30 day deaths, 100% recovery, tPA efficacy?
There is absolutely nothing in here that tells me that the RESULTS are better in this hospital than other hospitals. I don't give a crap about how well you do processes.
Big fucking whoopee.
Guidelines here: You can see how this is nothing to be impressed about. This is all indirect action, not results.
http://www.heart.org/HEARTORG/HealthcareResearch/GetWithTheGuidelinesHFStrokeResus/GetWithTheGuidelinesStrokeHomePage/Get-With-The-Guidelines-Stroke-Overview_UCM_308021_Article.jsp

The puffery article here:
http://www.kearneyhub.com/news/local/chi-health-earns-award-for-expertise-in-stroke-management/article_60e0d49e-2494-11e6-be44-6f62e385e919.html

CHI Health Good Samaritan has been honored for the way it treats strokes.
The hospital received the American Heart Association/American Stroke Association’s Get With The Guidelines Stroke Gold Plus Achievement Award with Target: StrokeSM Honor Roll Elite Plus.
The award recognizes the hospital’s adherence to nationally recognized, research-based guidelines to support better outcomes for stroke patients — faster recovery and reduced disability and mortality. Good Sam is the first hospital in Nebraska to earn this elite level of recognition. It has been a primary stroke center since 2011 and treats more than 200 stroke patients yearly.
“A stroke patient loses 1.9 million neurons each minute treatment is delayed,” said Pamela Palmer, a registered nurse with a bachelor’s degree in nursing. She is the intensive care and neuro-trauma educator, stroke coordinator. “At Good Samaritan Hospital, we are continually advancing, finding better ways to treat strokes faster and more safely. This award just reinforces our team’s drive to provide the most up-to-date care to our friends and neighbors.”
Good Samaritan has also met specific scientific guidelines as an Advanced Primary Stroke Center, featuring a comprehensive system for rapid diagnosis and treatment of stroke patients admitted to the emergency department.
A stoke is also known as a “brain attack,” and affects the brain in much the same way a heart attack affects the heart. A stroke occurs when a blood vessel to the brain is either blocked by a clot or bursts. As a result, part of the brain does not get the blood it needs and begins to die. The longer the blood flow is cut off to the brain, the greater the damage.
Recognizing symptoms and acting fast to get medical attention can save a life and limit disabilities.

Thursday, May 26, 2016

Memorial Hospital West Achieves AHA/ASA National Stroke Gold-Plus Award With Target: Stroke Honor Elite Plus Designation - Pembroke Pines, FL

A great stroke association leader would be contacting these hospitals and tell them to stop putting out these false puffery articles and just focus on their factual results. But that is a pipe dream of mine.
 These are NOT result awards so they don't tell you anything about how good the program is. Call that hospital president(


Aurelio M. Fernandez, III, FACHE

 

President and Chief Executive Officer,
Memorial Healthcare System

) 

telephone number: 954-265-5805

  and demand to know what the RESULTS are; 30 day deaths, 100% recovery, tPA efficacy?
There is absolutely nothing in here that tells me that the RESULTS are better in this hospital than other hospitals. I don't give a crap about how well you do processes.
Big f*cking whoopee.
Guidelines here: You can see how this is nothing to be impressed about. This is all indirect action, not results.
http://www.heart.org/HEARTORG/HealthcareResearch/GetWithTheGuidelinesHFStrokeResus/GetWithTheGuidelinesStrokeHomePage/Get-With-The-Guidelines-Stroke-Overview_UCM_308021_Article.jsp

The puffery article here:
http://www.benzinga.com/pressreleases/16/05/p8031590/memorial-hospital-west-achieves-ahaasa-national-stroke-gold-plus-award- 
Memorial Hospital West has received the American Heart Association/American Stroke Association's Get With The Guidelines®-Stroke Gold Plus Achievement Award with Target: StrokeSM Honor Roll Elite Plus designation.
This achievement, a second for Memorial Healthcare System, recognizes its commitment to emergency stroke care(not RESULTS) to ensure that stroke patients receive optimal treatment according to nationally recognized, evidence-based guidelines.
Memorial Regional Hospital was recognized for this level of achievement in 2015 for its excellence in stroke care and earned the Target Stroke Elite-Plus award again this year.
To receive the Gold Plus Quality Achievement Award, hospitals must achieve 85 percent or higher adherence to all Get With The Guidelines-Stroke achievement indicators for two or more consecutive 12-month periods and achieved 75 percent or higher compliance with five of eight Get With The Guidelines-Stroke Quality measures.
To qualify for the Target: Stroke Honor Roll Elite Plus, hospitals must meet quality measures developed to reduce the time between the patient's arrival at the hospital and treatment with the clot-buster tissue plasminogen activator, or tPA, the only drug approved by the U.S. Food and Drug Administration to treat ischemic stroke. If given intravenously in the first three hours after the start of stroke symptoms, tPA has been shown to significantly reduce the effects of stroke and lessen the chance of permanent disability.
Memorial Hospital West earned the award by meeting specific quality benchmarks for the diagnosis and treatment of stroke patients at a set level for a designated period. These quality measures are designed to help hospital teams provide the most up-to-date, evidence-based guidelines with the goal of speeding recovery and reducing death and disability for stroke patients.
"When it comes to treating stroke, 'time is brain,'" says Brijesh P. Mehta, MD, Medical Director, Stroke and Neurocritical Care, Memorial Neuroscience Institute. "Our multidisciplinary stroke team and the parallel system of care make Memorial Neuroscience Institute at two of our hospitals among the best stroke centers in the country - treating some of highest volumes of patients, with continually improving outcomes, and participating in ongoing landmark research studies to further strengthen our commitment to the field."
"We are pleased to recognize Memorial Hospital West for their commitment to stroke care," said Deepak L. Bhatt, M.D., M.P.H., national chairman of the Get With The Guidelines steering committee and Executive Director of Interventional Cardiovascular Programs at Brigham and Women's Hospital and Professor of Medicine at Harvard Medical School.
"Studies have shown that hospitals that consistently follow Get With The Guidelines quality improvement measures can reduce length of stay and 30-day readmission rates and reduce disparities in care."

 

Monday, May 16, 2016

Stroke Admissions Climb in Under-65s

I would argue that the simplistic reflex argument that prevention efforts are the main way to combat this problem is wrong. By not focusing on better rehabilitation your stroke leaders are leaving those who still get a stroke with the 90% failure rate of full recovery.
http://www.medpagetoday.com/Cardiology/Strokes/57926?xid=NL_breakingnews_2016-05-16&eun=g424561d0r
  • by Jeff Minerd
    Contributing Writer, MedPage Today

    Hospitalizations for ischemic stroke have increased in younger adults, according to two registry-based studies.
    In the U.S., acute ischemic stroke hospitalizations increased by almost 44% in adults, ages 25-44, during 2000-2010, but fell by more than 20% in those 65 and older, reported Lucas Ramirez, MD, of the University of Southern California in Los Angeles, and colleagues.
    In a separate study done in Denmark, hospitalizations increased by nearly 2% for stroke and approximately 4% for transient ischemic attack (TIA) in individuals, ages 15-30, from 1994-2012, according to Maiken Tibaek, a PhD candidate at the University of Copenhagen, and colleagues.
    Both studies appear in the Journal of the American Heart Association.
    "Overall, the hospitalization rate is down, with the greatest drop in people aged 65 and older," Ramirez said in an accompanying press release. "We can't say from this study design what factors have led to this decline, but it may be that preventive efforts, such as better blood pressure and blood sugar control, are having the effect that we want in this age group."
    "Stroke and transient ischemic attacks rarely occur in the young but may have a profound and long-lasting impact for the individual if they do," Tibaek said in a statement. "Compared to elderly individuals, strokes in the young may have greater economic impact because it impairs the ability to work during the most productive years of life."
    "For healthcare providers and patients, this study confirms the importance of focusing on prevention and addressing lifestyle-related risk factors to prevent stroke," Tibaek added. "It's also important that clinicians who see young adults with symptoms of stroke are aware that stroke is not that rare a diagnosis in younger adults."
    The U.S. Study
    Ramirez and colleagues analyzed data from the Nationwide Inpatient Sample, a database that includes information on approximately 8 million U.S. hospital stays per year, and represents a 20% stratified sample of non-federal U.S. hospitals.
    The investigators assessed trends in hospitalizations for stroke by age, sex, and race from 2000-2010.
    They found that overall hospitalization rates for stroke decreased by 18.4%. Specifically, rates decreased by 28.5% for adults (ages 65-84) and by 22.1% for adults 85 and older.
    However, rates increased by 43.8% for adults (ages 25-44) and by 4.7% for those 45-64.
    Also, rates decreased for Hispanics (-21.7%) and whites (-12.4%) but increased by 13.7% for blacks.
    Finally, rates decreased more for women (-22.1%) than men (-17.8%).
    Most of the decline in hospital admissions for stroke occurred during 2000-2005, with the figures plateauing after that. "The plateau from 2005 to 2010 could reflect a threshold beyond which our current prevention efforts are no longer having an effect..." Ramirez and colleagues wrote.
    The study had some limitations, namely that it was an observational study so causality cannot be assumed. Also, there was the possibility for coding errors, such as TIA miscoded as acute ischemic stroke. Lastly, because of demographic differences between the database and census data, acute ischemic stroke rates may have been underestimated in Hispanics, due to an inflated denominator when estimating the rate, the authors explained.
    "Our findings should be interpreted with caution," the U.S. investigators wrote, "since changes in stroke hospitalization rates are affected not only by true changes in incidence, but also stroke literacy and health beliefs (influencing likelihood of seeking medical attention), pre-hospital recognition and triage of patients with stroke symptoms, and hospital protocols/healthcare provider literacy (affecting the likelihood of hospitalizing individuals with stroke symptoms).
    "Nevertheless, the decline in stroke hospitalization rates could reflect reduced incidence, possibly due to cardiovascular prevention efforts, which have led to improved blood pressure and cholesterol treatment and control," Ramirez and colleagues concluded.
    The Danish Study
    Tibaek and colleagues analyzed data from the Danish National Patient Register, which includes all hospitalizations in Denmark since 1977. The investigators examined rates of first-time hospitalizations for stroke and TIA in people (ages 15-30) from 1994-2012.
    Incidence rates and estimated annual percentage changes (EAPCs) were estimated by using Poisson regression, the authors explained.
    During the study period, there were 4,156 cases of first-ever hospitalization for stroke/TIA identified.
    The age-standardized incidence rates of hospitalizations for stroke increased significantly (EAPC 1.83%. 95% CI 1.11–2.55%) from 11.97/100,000 person-years in 1994 to 16.77/100,000 person-yearsin 2012.
    TIA hospitalizations increased from 1.93/100,000 person-years in 1994 to 5.81/100,000 person-years in 2012. After 2006, the increase was more prominent in men than in women (EAPC 16.61%, 95% CI 10.45–23.12%).
    However, the incidence of hospitalizations for ischemic stroke was markedly lower among men, but increased significantly from 2006 (EAPC 14.60%, 95% CI 6.22–23.63%). Also, the incidences of hospitalizations for intracerebral hemorrhage and subarachnoid hemorrhage remained stable during the study period.
    "If the increase in ischemic stroke and transient ischemic attack is caused by changes in the overall cardiovascular risk profile of young adults, such as the increased prevalence of diabetes and obesity, our results can be applied to other countries with similar trends in cardiovascular risk profiles including the United States," Tibaek said.
    Study limitations included the the use of register-based design that tracked only hospitalized cases of stroke and TIA.
    The U.S. study was funded by the Roxanna Todd Hodges Foundation.
    The Danish study was funded by the Danish Ministry of Health and the Capital Region of Denmark.
    Ramirez and co-authors disclosed no relevant relationships with industry. One co-author disclosed support from the National Institute of Neurological and the American Heart Association.
    Tibaek and co-authors disclosed no relevant relationships with industry.
  • Reviewed by Henry A. Solomon, MD, FACP, FACC Clinical Associate Professor, Weill Cornell Medical College
  •  

Saturday, May 7, 2016

About that Johns Hopkins study on medical errors (podcast)

Well excuses abound, complacency exists in massive amounts in stroke.
http://medcitynews.com/2016/05/hopkins-medical-errors-podcast/?utm_source=MedCity+News+Subscribers&utm_campaign=f55987a874-MCN+Daily+Email&utm_medium=email&utm_term=0_5092836c41-f55987a874-408818725
My reply to this, we'll see if it is published or replied to:

If the definition of medical error is broad, meaning systemic errors, then it could easily cover every single 30day stroke death. Mainly because the neuronal cascade of death has been known since the 2009 Rockefeller University Newswire report. The 5 known causes of that cascade are out there ready to be solved. Dr. Michael Tymianski of the Toronto Western Hospital Research Institute
in Canada talks about 1000+ failed neuroprotective research trials. Yes, that will be difficult to solve but leaders step up to such challenges and don't make excuses.

Thursday, April 21, 2016

The most effective leaders clash with their company's culture

Since we have ineffective leaders in stroke our boards of directors should be looking for someone to completely upset the apple cart. Like maybe an insolent survivor.
http://digest.bps.org.uk/2016/04/the-best-leaders-clash-with-their.html?
Anyone will tell you that the most successful organisations have leaders who match the company culture. A CEO fixated on getting things done should lead somewhere driven by outcomes, a “mission culture”, whereas a people-focused leader suits a place focused on involvement and participation. This way everything is neat, tidy and aligned, with messages presented consistently, providing staff with reliable guides as to how to behave. But this is not what the data says in a new study published in the Journal of Applied Psychology. The new results argue that your leader shouldn’t line up with the culture – they should supply what it’s missing.

Chad Hartnell and his colleagues surveyed the management of firms within a technology consortium, asking members of 120 management teams to rate their CEOs on task leadership (e.g. “encourages the use of uniform policies”) and relational leadership (“is friendly and approachable”), and to rate their organisation’s culture on these same task and relation dimensions. The researchers wanted to find out which combinations of leadership and culture would, nine months later, show the greatest benefit in a tangible outcome: firm finances.

The data drew a gloomy picture for alignment. For relationship focus, mismatches were always better. Firms with a strong relational culture performed better when led by a leader with a low relational focus, and highly relational leaders were associated with stronger results when they operated in a culture with lower concern with relations. A similar picture emerged for task focus, where a combination of a high-focus culture and leader was the worst one possible. These associations held true even after controlling for past performance, CEO tenure and size of the firm.

Why could this be? When leader and culture are aligned, much of the leader’s efforts are redundant. When an organisation’s history of competition and high standards leads to a highly outcome focused culture, the CEO generates limited returns from focusing on task outcomes, as culture is acting as a "substitute for leadership". The job of a leader is to bring something new and needed to the table, such as a relational focus in a highly clinical culture.

Hartnell’s team point out their finding operates at a very broad level – more or less focus on people or outcomes – and that this shouldn’t be taken as querying whether leaders can ever be a misfit for a culture; clearly they can. So this study isn’t a paean to appointing disruptive contrarians, but rather, to considering the broader picture of what an organisation needs at any given time. Leaders who’ve been successful in steering their ship should reflect on whether the lessons they came to teach have now been learned, and whether it’s time to shift who they are as a leader, so they can begin to offer new ones.

_________________________________ ResearchBlogging.org

Hartnell, C., Kinicki, A., Schurer Lambert, L., Fugate, M., & Doyle Corner, P. (2016). Do Similarities or Differences Between CEO Leadership and Organizational Culture Have a More Positive Effect on Firm Performance? A Test of Competing Predictions. Journal of Applied Psychology DOI: 10.1037/apl0000083

Thursday, April 14, 2016

Abstract TP264: ST2 Signaling is Essential in Restricting Acute Ischemic Brain Injury

I don't understand so ask your doctor what use this will be for you. More studies needed so ask your doctor to update the stroke strategy and talk to the stroke leadership to followup this research.
http://stroke.ahajournals.org/content/47/Suppl_1/ATP264.short
  1. Jun Chen
+ Author Affiliations
  1. Univ of Pittsburgh, Pittsburgh, PA

Abstract

Background and Purpose: ST2, a member of the interleukin 1 receptor family, and its ligand interleukin 33 (IL-33) play critical roles in immune regulation and inflammatory responses. The engagement of ST2 has been shown to reduce myocardial infarction and preserve heart function. Recent study documented an increase in blood ST2 expression after stroke. The exact roles of ST2 in the ischemic brain injury, however, are not explored.
Methods: C57/BL6 wild type and ST2 knockout mice were subjected to 60-minute transient cerebral ischemia (tMCAO). The expression of ST2 and IL-33 in the ischemic brain was measured at different time points after tMCAO using RT-PCR. Brain infarct was quantified using TTC staining and MAP2 immunostaing. Neurobehavioral tests were performed up to 14 days after tMCAO. Differences of immune cell components in blood, spleen, bone marrow and brain between wild type and ST2 knockout mice were assessed by flow cytometry analysis. For experiments with ST2 activation, IL-33 was injected intraperitoneally(i.p.) or intracerebroventricularly (i.c.v.) into wide type mice right after the induction of tMCAO.
Results: In wild type mice, the mRNA expression of ST2 in the ischemic brainexhibited a delayed elevation 7d after tMCAO, while the mRNA expression of IL-33 was transiently increased 1d after tMCAO. The deficiency of ST2 resulted in enlarged infarct volume 3d after tMCAO and aggravated neurological deficits lasted out to 14d. The worsened stroke outcome was accompanied by dramatic changes in the number of Th1, Th2 and regulatory T cells in the spleen, bone marrow and brain. Further study showed that either i.p. or i.c.v. injection of IL-33 at the time of reperfusion attenuated the severity of brain infarct in wide type mice, suggesting that both systemic and central activation of ST2 could protect against acute ischemic brain injury.
Conclusions: ST2/IL-33 signaling plays an essential role in restricting acute ischemic brain injury. Such protective effect of ST2/IL-33 involves both immune regulation in the peripheral immune system and a direct protection within the central nervous system. Our study may provide a new therapeutic target for stroke treatment.

Wednesday, March 2, 2016

Human stem cell therapy in ischaemic stroke: a review

From 2011 so go ask your stroke medical leaders what has been updated in the past 5 years.
Human stem cell therapy in ischaemic stroke: a review
Age and Ageing 2011; 40: 7–13
doi: 10.1093/ageing/afq133
© The Author 2010. Published by Oxford University Press on behalf of the British Geriatrics Society.
All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Published electronically 10 November 2010

Friday, February 26, 2016

HIMSS exec: CIOs most concerned about new payment models - Value-based payments

Your doctor and stroke hospital will be up shit creek if this gets applied for stroke. Since tPA only works fully 12% of the time and full recovery from stroke is only 10% the payment stream from stroke is going to be non-existent. This is actually a good thing. Fear of non-payment could finally drive innovation in stroke, maybe solve the neuronal cascade of death, create a new drug to replace tPA. There are thousands of research possibilities that just need further research and translation to stroke protocols. This is all easily solvable if we have anyone with leadership skills and a focus on stroke strategy. 

HIMSS exec: CIOs most concerned about new payment models - Value-based payments


By Neil Versel
While it may seem like healthcare CIOs are thinking about cybersecurity and about the future of Meaningful Use, those issues are less important to many health IT professionals than the transition to value-based payments.
That’s according to Carla Smith, executive vice president of the Healthcare Information and Management Systems Society, which holds its annual conference next week in Las Vegas. HIMSS will share more details of its yearly CIO survey Tuesday morning, but Smith gave MedCity News a small preview in a podcast interview this week.
Other findings she hinted at are that IT has become a “strategically critical tool” for successful healthcare providers nationwide and that there is a correlation between the strategic value placed on IT and organizations who have clinical IT executives. More organizations are including clinical IT executives like chief medical information officers and chief nursing information officers in strategic decisions — typically reporting directly to the CFO or CEO — though it’s still not a majority, Smith said.
As usual, the endurance event known as the HIMSS conference keep growing. Attendance could approach 50,000, far above the record of 45,000 that came to HIMSS15 in Chicago, and the exhibit hall will include more than 1,300 vendors.
Smith called attention to a session with Centers for Medicare and Medicaid Services Administrator Andy Slavitt and national health IT coordinator Dr. Karen DeSalvo at 5:30 Pacific time Tuesday. They plan on keeping their prepared remarks brief and will take a lot of questions, Smith said, and she encouraged the health IT community to tweet their  questions with the hashtag #HIMSS16.
Listen to the podcast below.

Tuesday, January 19, 2016

Doctor’s Orders: Women Must Educate Themselves About Strokes

And doctors must educate themselves about all the fucking failures in stroke so when that patient gets to the stroke center hospital the patient has a better than 50/50 chance of getting to 100% recovery.
That will require solving a lot of BHAGs (Big Hairy Audacious Goals) but leaders tackle the hard problems. IS YOUR DOCTOR A LEADER or a FOLLOWER that is just sitting on the sidelines?
http://observer.com/2016/01/doctors-orders-women-must-educate-themselves-about-strokes/ 
 
Strokes afflict both men and women. However, women are more negatively impacted; stroke is the third cause of death in women, compared to the fifth leading cause of death in men. Every year, about 55,000 more women in America have a stroke than men. Among the more than 137,000 Americans who die from stroke each year, about 60 percent of them women. This year, it is estimated that more than 100,000 women in the U.S. under age 65 will have a stroke.
Some people might be thinking, ‘don’t women live longer than men?’ Yes, they do. But when it comes to stroke, this only means a longer life of poor quality. The National Stroke Association reports that more women will live alone when they have a stroke, will live in a healthcare facility after having a stroke, and have a worse recovery after having a stroke.
Only one in ten women was aware that hiccups that occur with unusual chest pain is an early warning sign of stroke.
A new study from Ohio State University Wexner Medical Center found that many women are unaware that there are female-specific warning signs and symptoms of stroke, such as hiccups that occur with unusual chest pain.
Men and women share some of the risk factors for stroke. This includes high blood pressure, smoking, and being sedentary. But there are a number of other risk factors that are specific to females, such as pregnancy (especially in final months and right after delivery), autoimmune disorders such as lupus and hormone replacement therapy.
According to a survey of 1,000 women, a number of women are unaware of these female-specific symptoms. A paltry one in ten women was aware that hiccups that occur with unusual chest pain is an early warning sign of stroke. And just 11 percent of the women were aware that pregnancy, lupus, migraine headaches, birth-control pills and hormone replacement therapy increase their stroke risk.
“I think we have a ways to go when it comes to educating women about stroke and their unique risk factors,” said Dr. Diana Greene-Chandos, director of neuroscience critical care at Ohio State University. She also noted that, “Things like pregnancy, hormone replacement therapy and even something as trivial as a case of the hiccups can all play an important role when it comes to strokes in women, and we need to be more aware of it.”
When someone is having a stroke, there is a window of three hours in which medications to break up clots will suffice. It’s important for women to become aware of these female-specific warning signs and symptoms because identifying stroke symptoms early can prevent severe damage.

Monday, January 11, 2016

Most younger people with stroke symptoms would not go to ER

With this as a reality our stroke world should stop blaming the victim and instead come up with solutions that are not time-dependent and barely work anyway(tPA?). There are lots of possibilities that just need additional research in the first days. I've only written about 484 posts on hyperacute items. Some of them should pan out.
Leaders solve problems, they don't blame victims for not following correct processes they know nothing about. But we can't expect anything better from our stroke associations. 

Most younger people with stroke symptoms would not go to ER


Sunday, January 10, 2016

Whole Body Vibration Therapy

Some day in the far far future after all the existing stroke non leaders are dead, we will run research that will determine if this has any use for stroke rehab. But until then you and all future stroke survivors are screwed.

Whole Body Vibration Therapy

Friday, January 8, 2016

I will continue with diligence to keep abreast of advances in medicine - Hippocratic Oath

Is your doctor keeping abreast of current research? If not, that is a problem of the stroke department head not setting correct goals for staff. Or maybe even higher, the president is not setting correct goals for department heads. Or do you have to go all the way to the board of directors? Someone is not being a leader.

The Hippocratic Oath

Tuesday, January 5, 2016

New Hope for Stroke Recovery

These John Hopkins people are missing the real problems in stroke. This is a prime example of failure in leadership from a supposed expert. Just 'happy talk' not realism.
http://m.hopkinsmedicine.org/health/healthy_aging/healthy_body/new-hope-for-stroke-recovery#.Vor2YojNQOM.twitter

While more people are surviving strokes, many still face long-term disability. But Johns Hopkins research finds promising ways to retrain the brain and regain independence. Here’s what experts have learned about the power of physical rehab.

Woman learning to walk again with the help of a physical therapist
Research Shows
Another Potential Key to Stronger Stroke Recovery
In the research, Johns Hopkins expert Steven Zeiler, M.D., Ph.D. and colleagues also found that lower levels of a protein called parvalbumin indicated that the premotor cortex had rewired after stroke. Parvalbumin marks the activity of a special class of nerve cells called inhibitory interneurons. Low levels of parvalbumin, and therefore lowered levels of inhibitory activity, is thought to help uninjured parts of the brain take over the injured parts, say researchers. This finding suggests that reducing inhibition in certain parts of the uninjured post-stroke brain (perhaps by using different medications and/or electrical stimulation) might promote recovery.
The good news about stroke: More people are surviving the initial stroke. The bad news about stroke: More people are surviving the initial stroke with disabilities which might have been minimized if they had received the kind of early, intensive physical rehabilitation that researchers find can improve function and reduce long-term disability. In fact, as many as 60 percent are left with diminished use of an arm or leg.

“When we speak about recovery we’re really talking about how the nervous system adapts to the brain missing a part of functioning tissue,” explains Johns Hopkins expert(Hah!) Steven Zeiler, M.D., Ph.D. “We’ve done all we could in the acute period,(Completely and totally wrong you solve the neuronal cascade of death. You're making an invalid assumption that new interventions won't be found. Be a leader, tackle the difficult problems), but the damage is done and it’s irreversible.(What about neurogenesis?)” The question then becomes, “How do you get the remainder of the nervous system to adapt?” In other words, can we get other parts of the brain to pick up the slack? Turns out that yes, we can.

Retraining the Brain

A groundbreaking Johns Hopkins study from Zeiler and his colleagues confirmed what clinicians have long suspected—we can rewire the brain so that one part takes over functions typically handled by another, now damaged, area.

In studies conducted with mice, the researchers first taught the mice a special way to reach for food. The task is typically directed by a part of the brain called the primary motor cortex, which is involved in physical coordination. Then they gave the mice mild strokes that damaged this motor cortex. As expected, the mice could no longer perform the reaching task with their pre-stroke level of precision. Two days after the stroke, however, researchers began retraining the mice and, after a week, the mice performed the task just as well as before the stroke.

The damaged part of the brain hadn’t recovered, says Zeiler. Instead, another part of the brain called the medial premotor cortex took over. To show that, researchers gave the mice strokes in that part of the brain and saw the reaching ability again disappear. But, once again, the mice relearned the task as yet another part of the brain stepped in to handle the job of the medial premotor cortex.

In a similar study, the researchers found that the earlier retraining started, the better. “If you retrained the mice after a one-day delay they got better, but after a seven-day delay they didn’t improve,” Zeiler says.

Johns Hopkins’ Kata Project, a collaboration between neuroscientists, engineers, animal experts, artists and entertainment industry experts, has designed an immersive experience for post-stroke patients who will try to “swim” as a virtual dolphin named Bandit. Upcoming clinical trials will determine if this unique experience helps patients recover motor function faster than the current conventional treatment of repetitive exercises.

The Power of Stroke Rehab

The take-home message of the research, says Zeiler, is that “early and intense” rehabilitation—even while still hospitalized—is critical in stroke recovery. Unfortunately, that’s not always the standard practice, he says. “As a medical community we need to push for immediate and intense change in rehabilitation.”