Deans' stroke musings: Physical activity and risk of Alzheimer disease: A 2-sample Mendelian randomization study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, October 11, 2020

Physical activity and risk of Alzheimer disease: A 2-sample Mendelian randomization study

I have no fucking clue what this says. Your mentors and senior researchers need to be fired for allowing this to be published like this.

Physical activity and risk of Alzheimer disease: A 2-sample Mendelian randomization study

Sebastian E. Baumeister, André Karch, Martin Bahls, , , Hansjörg Baurecht

First published July 17, 2020, DOI: https://doi.org/10.1212/WNL.0000000000010013

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Abstract

Objective Evidence from observational studies for the effect of physical activity on the risk of Alzheimer disease (AD) is inconclusive. We performed a 2-sample mendelian randomization analysis to examine whether physical activity is protective for AD.

Methods Summary data of genome-wide association studies on physical activity and AD were used. The primary study population included 21,982 patients with AD and 41,944 cognitively normal controls. Eight single nucleotide polymorphisms (SNPs) known at p < 5 × 10⁻⁸ to be associated with average accelerations and 8 SNPs associated at p < 5 × 10⁻⁷ with vigorous physical activity (fraction of accelerations >425 milligravities) served as instrumental variables.

Results There was no association between genetically predicted average accelerations with the risk of AD (inverse variance weighted odds ratio [OR] per SD increment: 1.03, 95% confidence interval 0.97–1.10, p = 0.332). Genetic liability for fraction of accelerations >425 milligravities was unrelated to AD risk.

Conclusion The present study does not support a causal association between physical activity and risk of AD.