Deans' stroke musings: Immunohistochemical study on the effect of soft diet and omega 3-fortified soft diet on neurogenesis in the rat dentate gyrus and the subventricular z

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, October 1, 2011

Immunohistochemical study on the effect of soft diet and omega 3-fortified soft diet on neurogenesis in the rat dentate gyrus and the subventricular z

This follows one of my earlier posts on DHA and omega oils here:
http://oc1dean.blogspot.com/2011/02/fish-oil-component-and-stroke-rehab.html
new article here: on rats
http://journals.lww.com/ejhistology/Abstract/2011/09000/Immunohistochemical_study_on_the_effect_of_soft.11.aspx

Abstract

Background: Adult brain neurogenesis persists in the subventricular zone (SVZ) and in the subgranular zone (SGZ) of the dentate gyrus. Modulation of neurogenesis by diet is a mechanism by which nutrition affects memory, learning, and mood.

Aim of the study: To study the effect of the soft diet with or without omega 3 fatty acids on neurogenesis.

Materials and methods: Thirty weaned male albino rats (3 weeks) were divided into three groups. Group 1 (control group) were fed on hard diets, group 2 were fed on soft diets, and group 3 were fed on soft diets plus omega 3 fatty acids for 3 months. Nerve cell proliferation in the SVZ and the SGZ was detected immunohistochemically using thymidine analog bromodeoxyuridine (BrdU). The results were statistically analyzed.

Results: In the dentate gyrus, there was a significant increase in the number of BrdU-positive cells in groups 1 and 3 compared with group 2. Meanwhile in the SVZ, there was a significant increase in the number of BrdU-positive cells in group 3 compared with group 1. In group 1, the newly formed cells in the SGZ reached the granular cell layer of the dentate gyrus. The newly formed cells in the SVZ reached the olfactory bulb (OB) after 2 weeks but failed to survive for 4 weeks in the OB. In group 2, few newly formed cells reached the granular cell layer of the dentate gyrus, but they failed to reach the OB. In group 3, the newly formed cells reached their destination in the granular cell layer of the dentate gyrus and the OB. In the OB, the cells succeeded to survive for 4 weeks and were incorporated among the granular cells of OB.

Conclusion: Hard diet and omega 3-fortified soft diet had a stimulatory effect on the process of neurogenesis in the dentate gyrus. Meanwhile in the SVZ, fortified soft diet had more stimulatory effect on proliferation and improvement of the survival rate of the newly formed cells than the hard diet.

When the hell is a scientist going to put all this neurogenesis stuff into one coherent article? I'm waiting for any stroke association to take this on. Waiting, waiting!!!!