Ask your competent? doctor which of the 5 causes of the neuronal cascade of death
this addresses. Don't ever use the word 'neuroprotection'; it doesn't signify urgency at all! If your doctor tells you they weren't able to stop the neuronal cascade of death, your first assumption would be why not? Are you that fucking incompetent?
Words matter, insist your doctor use them correctly.
And nothing here gives amounts, so absolutely fucking useless!
The richest plant sources of kaempferol (mg/100 g fresh weight) are green leafy vegetables, including spinach and kale, and herbs such as dill, chives, and tarragon.
The leaves of wild leeks or ramps (100g fresh weight) were reported to
contain 50.2 and 32.5 mg of quercetin and kaempferol, respectively [17].
Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders
Abstract
Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, has garnered increasing attention due to its potential neuroprotective effects in neurological diseases. This research examines the existing literature concerning the involvement of kaempferol in neurological diseases, including stroke, Parkinson's disease, Alzheimer's disease, neuroblastoma/glioblastoma, spinal cord injury, neuropathic pain, and epilepsy. Numerous in vitro and in vivo investigations have illustrated that kaempferol possesses antioxidant, anti-inflammatory, and antiapoptotic properties, contributing to its neuroprotective effects. Kaempferol has been shown to modulate key signaling pathways involved in neurodegeneration and neuroinflammation, such as the PI3K/Akt, MAPK/ERK, and NF-κB pathways. Moreover, kaempferol exhibits potential therapeutic benefits by enhancing neuronal survival, attenuating oxidative stress, enhancing mitochondrial calcium channel activity, reducing neuroinflammation, promoting neurogenesis, and improving cognitive function. The evidence suggests that kaempferol holds promise as a natural compound for the prevention and treatment of neurological diseases. Further research is warranted to elucidate the underlying mechanisms of action, optimize dosage regimens, and evaluate the safety and efficacy of this intervention in human clinical trials, thereby contributing to the advancement of scientific knowledge in this field.
Significance statement
Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, to serve as a natural neuroprotective agent for the prevention and treatment of neurological disorders. By conducting an extensive review of the current literature, this study underscores the varied mechanisms through which kaempferol demonstrates its neuroprotective effects, emphasizing its antioxidant, anti-inflammatory, and antiapoptotic properties. Furthermore, the therapeutic potential of kaempferol in modulating key signaling pathways involved in neurodegeneration and neuroinflammation, such as the PI3K/Akt, MAPK/ERK, and NF-κB pathways, is underscored. Additionally, various beneficial effects of kaempferol, including enhancing neuronal survival, attenuating oxidative stress, reducing neuroinflammation, promoting neurogenesis, and improving cognitive function, are emphasized. In summary, compelling evidence is presented supporting the use of kaempferol as a promising natural compound for the prevention and treatment of neurological diseases, thereby indicating the importance of further research to elucidate the mechanisms of action, optimize dosage regimens, and assess the safety and efficacy of kaempferol in human clinical trials.
No comments:
Post a Comment