Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, March 27, 2025

Unraveling Berberine's Molecular Mechanisms in Neuroprotection against Neurodegeneration

 

 I started using berberine years ago because this: Berberine reduces triglycerides levels and systolic blood pressure.123,124

Don't follow me, I'm not medically trained, is your doctor trained in this?

Novel Berberine Drug Cut HbA1c in Type 2 Diabetes

The latest here:

Unraveling Berberine's Molecular Mechanisms in Neuroprotection against Neurodegeneration

Md Zamshed Alam Begh  1 , Md Al Amin  2 , Mst Maharunnasa Shatu  3 , Sherouk Hussein Sweilam  4 , Sachin Puri  5 , Bhagyashri Rathod  5 , Uppuluri Varuna Naga Venkata Arjun  6 , Thukani Sathanantham Shanmugarajan  6 , Nagaveni Pommala  7 , Akiladevi Durairaj  6 , Susithra Ethiraj  8 , Nagarajan Shenbakadurai  9 , Irfan Ahmad  10 , Talha Bin Emran  11
Affiliations

Abstract

Neurodegenerative diseases (NDs) exhibit significant global public health challenges due to the lack of effective treatments. Berberine (BBR), a natural alkaloid compound in various plants, has been recognized for its potential neuroprotective properties. This review explores the current understanding of BBR's mechanisms of action and its therapeutic potential in preventing and treating NDs such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. BBR's neuroprotective properties are attributed to its multifaceted actions, including anti-inflammatory, antioxidant, anti-apoptotic, and neurotrophic effects. Additionally, BBR can influence many signaling pathways involved in neurodegeneration, including AMP-activated protein kinase, nuclear factor erythroid 2-related factor 2, and brain-derived neurotrophic factor pathways. Furthermore, BBR targets vital signaling pathways, including AMPK, PI3K/Akt, and MAPK, essential for developing NDs. In addition, BBR's efficacy in reducing neurodegenerative pathology and improving cognitive function has been demonstrated through preclinical studies using cellular and animal models. Clinical trials demonstrating BBR's therapeutic potential in NDs have yielded promising results, but further research is needed to confirm its safety and efficacy in humans. BBR holds potential as a novel neuroprotective agent for preventing and treating NDs, providing a promising avenue for future therapeutic interventions.     

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