I'm sure your doctor and researcher know that one of the 6 causes of neuronal cascade of death is Capillaries that don't open due to pericytes not letting go.
So you need to remind them to be careful that solving that problem doesn't restrict this migration.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=142225&CultureCode=en
Two years ago, a new type of stem cell was discovered in the brain
that has the capacity to form new cells. The same research group at Lund
University in Sweden has now revealed that these stem cells, which are
located in the outer blood vessel wall, appear to be involved in the
brain reaction following a stroke.
The findings show that the cells, known as pericytes, drop out from
the blood vessel, proliferate and migrate to the damaged brain area
where they are converted into microglia cells, the brain’s inflammatory
cells.
Pericytes are known to contribute to tissue repair in a number of
organs, and the researchers believe that their reparative properties
could also apply to the brain. The study shows for the first time that
pericytes are directly involved in the reaction of the brain tissue
after stroke.
“Pericytes are a fascinating cell type with many different properties
and found at high density in the brain. It was surprising that a
pericyte subtype is so strongly activated after a stroke. The fact that
pericytes can be converted into microglia, which have an important
function in the brain after a stroke, was an unexpected finding that
opens up a new possibility to influence inflammation
associated with a stroke”, said Gesine Paul-Visse, neurologist at Lund University and senior author of the study.
Using a green fluorescent protein bound to the pericytes, the
researchers were able to track the cells’ path to the damaged part of
the brain. The migration takes place within a week after a stroke. When
the cells reach the site of damage they are converted into microglia
cells, the ‘cleaners’ of the central nervous system. Inflammation can,
however, have both positive reparative effects and negative effects on
the damaged tissue. The exact role of microglia cells in the
regeneration after a stroke is not entirely clear, but we do know that
pericytes play an important role in protecting the brain against disease
and injury.
“We now need to elucidate how pericytes affect the brain’s recovery
following a stroke. Our findings put pericytes in focus as a new target
for brain repair and future research will help us understand more about
the brain’s own defence and repair mechanisms.”
There is an urgent need for new drugs that can alleviate the harmful
effects of a stroke as current treatment possibilities using
thrombolysis are limited to the first hours following a stroke.
“Because inflammation following a stroke is an event that continues
after the acute stage, we hope that targeting pericytes in the subacute
phase after stroke, i.e. within a longer time window following the onset
of stroke, may influence the outcome”, said Gesine Paul-Visse.
http://dx.doi.org/10.1007/s00401-014-1295-x
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