What is your doctor doing to unstick your synapses? Is this your memory problem rather than the stroke?
http://news.ubc.ca/2014/05/26/sticky-synapses-can-impair-new-memories-by-holding-on-to-old-ones/
University of British Columbia researchers have discovered that
so-called “sticky synapses” in the brain can impair new learning by
excessively hard-wiring old memories and inhibiting our ability to adapt
to our changing environment.
Memories are formed by strong synaptic connections between nerve
cells. Now a team of UBC neuroscientists has found that synapses that
are too strong or “sticky” can actually hinder our capacity to learn new
things by affecting cognitive flexibility, the ability to modify our
behaviours to adjust to circumstances that are similar, but not
identical, to previous experiences.
“We tend to think that strong retention of memories is always a good
thing,” says Fergil Mills, UBC PhD candidate and the study’s first
author. “But our study shows that cognitive flexibility involves
actively weakening old memory traces. In certain situations, you have to
be able to ‘forget’ to learn.”
The study, published today in the Proceedings of the National Academy of Sciences,
shows that mice with excessive beta-catenin – a protein that is part of
the “molecular glue” that holds synapses together – can learn a task
just as well as normal mice, but lacked the mental dexterity to adapt if
the task was altered.
“Increased levels of beta-catenin have previously been reported in
disorders such as Alzheimer’s disease and Huntington’s disease, and,
intriguingly, patients with these diseases have been shown to have
deficits in cognitive flexibility similar to those we observed in this
study,” says Shernaz Bamji, an associate professor in UBC’s Dept. of
Cellular and Physiological Sciences.
“Now, we see that changes in beta-catenin levels can dramatically
affect learning and memory, and may indeed play a role in the cognitive
deficits associated with these diseases,” she adds. “This opens up many
exciting new avenues for research into these diseases and potential
therapeutic approaches.”
More at link.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,116 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Monday, May 26, 2014
‘Sticky synapses’ can impair new memories by holding on to old ones
Labels:
beta-catenin,
doctor question,
memory,
mice,
synapses
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