Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 17, 2015

Cohen's Brain Bits: Bio-Marks the Spot in TBI?

A great stroke association would be building on this research to see if blood biomarkers could be used to diagnose stroke damage and recovery also. But hell, let's be realistic this is not going to occur under the current leadership.
http://www.medpagetoday.com/Neurology/HeadTrauma/49569?
As public scrutiny surrounding concussion continues to intensify, so too does the search for objective data to diagnose and track improvement following traumatic brain injury (TBI). Blood biomarkers would be an excellent noninvasive solution -- assuming they were a reliable measure of damage, correlated with the severity of damage, improved in concert with clinical recovery, and blood tests to assess the biomarkers were both sensitive and specific. That's a tall order, one which has been the subject of considerable debate over the past few years and has thus far remained elusive.
To date, the literature supporting the utility of blood biomarkers in the detection of brain injury and monitoring of its healing has been promising, though researchers have recognized some of the limitations in interpreting results. The greatest challenge has been detection -- concentrations of biomarkers in the blood are too low for many assays. Other barriers include plasma protein binding, renal or hepatic clearance of biomarkers, proteolysis in the blood, and extracerebral sources of the proteins. However, despite these considerable obstacles, many papers published continue to bolster biomarker backers.
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This week, researchers at the University of Rochester Medical Center published a new study that I believe moves us one step closer to making biomarker measurement a clinically useful reality. They solved the puzzle of how biomarkers make their way to the blood -- the so-called glymphatic system. Blocking the glymphatic system prevented biomarkers from reaching the blood, thus establishing the glymphatic system as the "primary highway" by which proteins leaking out of neurons or glial cells after TBI would reach the blood.

More at link.

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