How many times will exercise be found as helpful in preventing/delaying dementia before your doctor sets up a stroke protocol to address this problem?
http://www.ncbi.nlm.nih.gov/pubmed/25574797
Abstract
PURPOSE:
This
study investigated the effect of treadmill running on cognitive
declines in the early and advanced stages of Alzheimer's disease (AD) in
3xTg-AD mice.
METHODS:
At
4 months of age, 3xTg-AD mice (N=24) were assigned to control (AD+CON,
n=12) or exercise (AD+EX, n=12) group. At 24 months of age, 3xTg-AD mice
(N=16) were assigned to AD+CON (n=8) or AD+EX (n=8) group. The AD+EX
mice were subjected to treadmill running for 12-week. At each pathologic
stage, the background strain mice were included as wild type control
(WT+CON, n=8-12).
RESULTS:
At
the early stage of AD, 3xTg-AD mice had impaired short- and long-term
memory based on Morris water maze along with higher cortical Aβ
deposition, higher hippocampal and cortical tau pathology, and lower
hippocampal and cortical PSD-95 and synaptophysin. A 12-week treadmill
running reversed the impaired cognitive declines and significantly
improved the tau pathology along with suppression of the decreased
PSD-95 and synaptophysin in the hippocampus and cortex. At the advanced
stage of AD, 3xTg-AD mice had impaired short- and long-term memory along
with higher levels of Aβ deposition, soluble Aβ1-40 and Aβ1-42, tau
pathology, and lower levels of BDNF, PSD-95 and synaptophysin in the
hippocampus and cortex. A 12-week treadmill running reversed the
impaired cognitive declines and significantly improved the Aβ and tau
pathology along with suppression of the decreased synaptic proteins and
BDNF in the hippocampus and cortex.
CONCLUSION:
The
current findings suggest that treadmill running provides a
non-pharmacologic means to combat cognitive declines due to AD
pathology.
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