I bet your doctor reflexively tells you not to drink alcohol. Up to your discretion.
Alcohol for these 12 reasons.
A little daily alcohol may cut stroke risk
An occasional drink doesn't hurt coronary arteries
Negative here:
Binge alcohol alters exercise-driven neuroplasticity
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- Binge alcohol exerts a prolonged influence on cortical microglia morphology.
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- Exercise increases cortical microglia.
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- Binge alcohol suppresses this exercise-driven increase in microglia.
Abstract
Exercise
is increasingly being used as a treatment for alcohol use disorders
(AUD), but the interactive effects of alcohol and exercise on the brain
remain largely unexplored. Alcohol damages the brain, in part by
altering glial functioning. In contrast, exercise promotes glial health
and plasticity. In the present study, we investigated whether binge
alcohol would attenuate the effects of subsequent exercise on glia. We
focused on the medial prefrontal cortex (mPFC), an alcohol-vulnerable
region that also undergoes neuroplastic changes in response to exercise.
Adult female Long-Evans rats were gavaged with ethanol (25% w/v) every
8 h for 4 days. Control animals received an isocaloric, non-alcohol
diet. After 7 days of abstinence, rats remained sedentary or exercised
for 4 weeks. Immunofluorescence was then used to label microglia,
astrocytes, and neurons in serial tissue sections through the mPFC.
Confocal microscope images were processed using FARSIGHT, a
computational image analysis toolkit capable of automated analysis of
cell number and morphology. We found that exercise increased the number
of microglia in the mPFC in control animals. Binged animals that
exercised, however, had significantly fewer microglia. Furthermore,
computational arbor analytics revealed that the binged animals
(regardless of exercise) had microglia with thicker, shorter arbors and
significantly less branching, suggestive of partial activation. We found
no changes in the number or morphology of mPFC astrocytes. We conclude
that binge alcohol exerts a prolonged effect on morphology of mPFC
microglia and limits the capacity of exercise to increase their numbers.
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