Since most of my premotor cortex is dead any forced use would fail, so you need to come up with a plan for dead brain recovery. This is just cherry picking low hanging rehab fruit. Solve the difficult problems like leaders do. Are you a leader or a mouse?
Reorganization of Ventral Premotor Cortex After Ischemic Brain Injury: Effects of Forced Use
Abstract
Background
Physical use of the affected upper extremity can have a beneficial effect on motor recovery in people after stroke. Few studies have examined neurological mechanisms underlying the effects of forced use in non-human primates. In particular, the ventral premotor cortex (PMV) has been previously implicated in recovery after injury.
Objective
To examine changes in motor maps in PMV after a period of forced use following ischemic infarct in primary motor cortex (M1).
Methods
Intracortical microstimulation (ICMS) techniques were used to derive motor maps in PMV of four adult squirrel monkeys before and after an experimentally induced ischemic infarct in the M1 distal forelimb area (DFL) in the dominant hemisphere. Monkeys wore a sleeved jacket (generally 24 hrs/day) that forced limb use contralateral to the infarct in tasks requiring skilled digit use. No specific rehabilitative training was provided.
Results
At 3 mos post-infarct, ICMS maps revealed a significant expansion of the DFL representation in PMV relative to pre-infarct baseline (mean = +77.3%; n = 3). Regression analysis revealed that the magnitude of PMV changes was largely driven by M1 lesion size, with a modest effect of forced use. One additional monkey examined after ∼18 months of forced use demonstrated a 201.7% increase, unprecedented in non-human primate studies.
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