Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, August 27, 2022

Associations of Sensory and Motor Function with Blood-Based Biomarkers of Neurodegeneration and Alzheimer's Disease in Midlife

 

With your elevated risk of Alzheimers/dementia you'll want your doctor following this carefully.  Is your doctor ensuring further studies occur?

Or is your doctor incompetently WAITING FOR SOMEONE ELSE TO SOLVE THE PROBLEM? 

Your risk of dementia, has your doctor told you of this?

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018 

What is your doctor's EXACT PROTOCOL TO PREVENT DEMENTIA?

The latest here:

Associations of Sensory and Motor Function with Blood-Based Biomarkers of Neurodegeneration and Alzheimer's Disease in Midlife

https://doi.org/10.1016/j.neurobiolaging.2022.08.008Get rights and content

Highlights

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Serum NfL and Tau levels increased, and Aβ42/Aβ40 ratio decreased over 10 years

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Serum NfL levels correlated well with NfL levels in plasma and CSF

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Serum NfL was higher and Aβ42/Aβ40 ratio lower in those with CSF or PET amyloid

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Midlife hearing impairment associated with faster increase in NfL level over time

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Worse midlife motor function associated with faster increase in NfL over time

Abstract

Pathological biomarkers of dementia and Alzheimer's disease (AD) change decades before clinical symptoms. Common sensory and motor changes in aging adults may be early markers of neurodegeneration. We investigated if midlife sensory and motor functions in Beaver Dam Offspring Study (BOSS) participants (N=1529) were associated with longitudinal changes in blood-based biomarkers of neurodegeneration (neurofilament light chain (NfL); total tau (TTau)) and AD (amyloid beta (Aβ)). Mixed-effects models with baseline sensory and motor function as determinants and 10-year biomarker change as outcome were used. Participants with hearing impairment and worse motor function (among women) showed faster increases in NfL level over time (0.8%/year; 0.3%/year, respectively). There were no significant associations with TTau or Aβ.

We found consistent relationships between worse baseline hearing and motor function with a faster increase in neurodegeneration, specifically serum NfL level. Future studies with longer follow-up should determine if sensory and motor changes are more reflective of general neurodegeneration than AD-specific pathology and whether sensory and motor tests may be useful screening tools for neurodegeneration risk.

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