Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 18, 2025

Modified Stem Cells Show Promise In Restoring Brain Activity After Stroke, Study Reveals

 But brain activity does not necessarily mean recovery has occurred. So, they didn't even have the right endpoint measured. With only 1 percent of stem cells surviving, I'd suggest that the exosomes created from the stem cells are the real reason. So, I'd don't think the title corresponds to what actually was observed.

But why go thru all the trouble of stem cells if exosomes are the reason for the benefits? Which must be why no one seems to be monitoring stem cell survival.

Application of stem cell-derived exosomes in ischemic diseases: opportunity and limitations 

The latest here:

Modified Stem Cells Show Promise In Restoring Brain Activity After Stroke, Study Reveals

New Delhi: Modified stem cells can be a significant new hope for improving brain activity among people who survive a stroke, according to a study.

For survivors of the most common type of stroke, called an ischemic stroke, only about 5 per cent fully recover. Stroke patients generally suffer from long-term problems, including weakness, chronic pain, or epilepsy.

Scientists at Gladstone Institutes showed that a cell therapy derived from stem cells can restore normal patterns of brain activity after a stroke. Most treatments turn effective only after being administered in the immediate hours after a stroke, the new therapy, tested in rats, appeared beneficial even when given one month later.

About The Study

The new study, published in the journal Molecular Therapy, is the first to detail the effects of stem cells on brain activity. The findings could lead to improvements in stem cell therapy. It may also contribute to the development of other treatments with similar impacts on the brain.

In the new study, the team tested the novel stem cell therapy in rats. The therapy has been in clinical development for more than a decade to treat stroke and traumatic brain injuries.

Clinical trials have already indicated that, in some patients, the stem cells could help people regain control of their arms and legs.

However, scientists were unsure what changes in the brain contributed to these improvements in symptoms.

The team led by Jeanne Paz injected modified human stem cells into the animals’ brains near the site of injury, a month after suffering a stroke.

To probe the benefits, the scientists measured electrical activity in the brains. Individual cells and molecules were also analysed. The results showed reversed brain hyperexcitability in rats with strokes. This helped restore balance in neural networks.

Further, the treatment also increased the number of proteins and cells that are important for brain function and repair. While fewer than one per cent of the human cells remained in the rats’ brains after a week following the transplant -- the effects of the transplants were long-lasting, Paz said.

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