http://now.tufts.edu/news-releases/new-way-diagnose-brain-damage-concussions-strokes-and-dementia
New
optical diagnostic technology developed at Tufts University School of
Engineering promises new ways to identify and monitor brain damage
resulting from traumatic injury, stroke or vascular dementia—in real
time and without invasive procedures.
Coherent hemodynamics spectroscopy (CHS), developed and published by Tufts Professor of Biomedical Engineering Sergio Fantini, measures blood flow, blood volume, and oxygen consumption in the brain. It uses non-invasive near infrared (NIR) light technology to scan brain tissue, and then applies mathematical algorithms to interpret that information.
"CHS is based on measurements of brain hemodynamics that are interpreted according to unique algorithms that generate measures of cerebral blood flow, blood volume and oxygen consumption," says Fantini. "This technique can be used not only to assess brain diseases but also to study the blood flow and how it is regulated in the healthy brain."
Tufts has licensed CHS on a non-exclusive basis to ISS, a Champaign, Ill.-based company that specializes in technology to measure hemoglobin concentration and oxygenation in brain and muscle tissue.
"Potentially the market for CHS is large as it encompasses several applications from the monitoring of cerebrovascular disorders to assessing neurological disorders," says Beniamino Barbieri, president of ISS. "It reminds me of the introduction of ultrasound technology at beginning of the seventies; nobody back then knew how to utilize the new technology and of course, nowadays, its applications are ubiquitous in any medical center."
How It Works
CHS uses laser diodes which emit NIR light that is delivered to the scalp by fiber optics. Light waves are absorbed by the blood vessels in the brain. Remaining light is reflected back to sensors, resulting in optical signals that oscillate with time as a result of the heartbeat, respiration, or other sources of variations in the blood pressure.
By analyzing the light signals with algorithms developed for this purpose, Fantini's model is able to evaluate blood flow and the way the brain regulates it--which is one marker for brain health.
CHS technology has been tested among patients undergoing hemodialysis at Tufts Medical Center. Published research reported a lower cerebral blood flow in dialysis patients compared with healthy patients. "Non-invasive ways to measure local changes in cerebral blood flow, particularly during periods of stress such as hemodialysis, surgeries, and in the setting of stroke, could have major implications for maintaining healthy brain function," says Daniel Weiner, M.D., a nephrologist at Tufts Medical Center (Tufts MC) and associate professor of medicine at Tufts University School of Medicine (TUSM), who is a member of the research team.
Josh Kornbluth, M.D., a neurologist at Tufts MC and associate professor of medicine at TUSM, is also working with Fantini to explore CHS's potential to assess the cerebrovascular state of patients who suffer traumatic brain injury or stroke. They hope to test CHS further among neurological critical care patients.
"Having data about local cerebral blood flow and whether it is properly regulated can allow us to more accurately develop individualized therapy and interventions instead of choosing a 'one size fits all' approach to traumatic brain injury, stroke, or subarachnoid hemorrhage," Kornbluth says.
- See more at: http://now.tufts.edu/news-releases/new-way-diagnose-brain-damage-concussions-strokes-and-dementia#sthash.7YSIn7KB.dpuf
Coherent hemodynamics spectroscopy (CHS), developed and published by Tufts Professor of Biomedical Engineering Sergio Fantini, measures blood flow, blood volume, and oxygen consumption in the brain. It uses non-invasive near infrared (NIR) light technology to scan brain tissue, and then applies mathematical algorithms to interpret that information.
"CHS is based on measurements of brain hemodynamics that are interpreted according to unique algorithms that generate measures of cerebral blood flow, blood volume and oxygen consumption," says Fantini. "This technique can be used not only to assess brain diseases but also to study the blood flow and how it is regulated in the healthy brain."
Tufts has licensed CHS on a non-exclusive basis to ISS, a Champaign, Ill.-based company that specializes in technology to measure hemoglobin concentration and oxygenation in brain and muscle tissue.
"Potentially the market for CHS is large as it encompasses several applications from the monitoring of cerebrovascular disorders to assessing neurological disorders," says Beniamino Barbieri, president of ISS. "It reminds me of the introduction of ultrasound technology at beginning of the seventies; nobody back then knew how to utilize the new technology and of course, nowadays, its applications are ubiquitous in any medical center."
How It Works
CHS uses laser diodes which emit NIR light that is delivered to the scalp by fiber optics. Light waves are absorbed by the blood vessels in the brain. Remaining light is reflected back to sensors, resulting in optical signals that oscillate with time as a result of the heartbeat, respiration, or other sources of variations in the blood pressure.
By analyzing the light signals with algorithms developed for this purpose, Fantini's model is able to evaluate blood flow and the way the brain regulates it--which is one marker for brain health.
CHS technology has been tested among patients undergoing hemodialysis at Tufts Medical Center. Published research reported a lower cerebral blood flow in dialysis patients compared with healthy patients. "Non-invasive ways to measure local changes in cerebral blood flow, particularly during periods of stress such as hemodialysis, surgeries, and in the setting of stroke, could have major implications for maintaining healthy brain function," says Daniel Weiner, M.D., a nephrologist at Tufts Medical Center (Tufts MC) and associate professor of medicine at Tufts University School of Medicine (TUSM), who is a member of the research team.
Josh Kornbluth, M.D., a neurologist at Tufts MC and associate professor of medicine at TUSM, is also working with Fantini to explore CHS's potential to assess the cerebrovascular state of patients who suffer traumatic brain injury or stroke. They hope to test CHS further among neurological critical care patients.
"Having data about local cerebral blood flow and whether it is properly regulated can allow us to more accurately develop individualized therapy and interventions instead of choosing a 'one size fits all' approach to traumatic brain injury, stroke, or subarachnoid hemorrhage," Kornbluth says.
- See more at: http://now.tufts.edu/news-releases/new-way-diagnose-brain-damage-concussions-strokes-and-dementia#sthash.7YSIn7KB.dpuf
New optical diagnostic technology
developed at Tufts University School of Engineering promises new ways to
identify and monitor brain damage resulting from traumatic injury, stroke or
vascular dementia—in real time and without invasive procedures.
Coherent hemodynamics spectroscopy
(CHS), developed and published by Tufts Professor of Biomedical
Engineering Sergio Fantini, measures blood flow, blood volume, and
oxygen consumption in the brain. It uses non-invasive near infrared (NIR) light
technology to scan brain tissue, and then applies mathematical algorithms to
interpret that information.
"CHS is based on measurements
of brain hemodynamics that are interpreted according to unique algorithms that
generate measures of cerebral blood flow, blood volume and oxygen
consumption," says Fantini. "This technique can be used not only to
assess brain diseases but also to study the blood flow and how it is regulated
in the healthy brain."
Tufts has licensed CHS on a
non-exclusive basis to ISS, a Champaign, Ill.-based company that specializes in
technology to measure hemoglobin concentration and oxygenation in brain and
muscle tissue.
"Potentially the market for CHS
is large as it encompasses several applications from the monitoring of
cerebrovascular disorders to assessing neurological disorders," says
Beniamino Barbieri, president of ISS. "It reminds me of the introduction
of ultrasound technology at beginning of the seventies; nobody back then knew
how to utilize the new technology and of course, nowadays, its applications are
ubiquitous in any medical center."
How It Works
CHS uses laser diodes which emit NIR
light that is delivered to the scalp by fiber optics. Light waves are absorbed
by the blood vessels in the brain. Remaining light is reflected back to
sensors, resulting in optical signals that oscillate with time as a result of
the heartbeat, respiration, or other sources of variations in the blood
pressure.
By analyzing the light signals with
algorithms developed for this purpose, Fantini's model is able to evaluate
blood flow and the way the brain regulates it--which is one marker for brain
health.
CHS technology has been tested among
patients undergoing hemodialysis at Tufts Medical Center. Published
research reported a lower cerebral blood flow in dialysis patients compared
with healthy patients. "Non-invasive ways to measure local
changes in cerebral blood flow, particularly during periods of stress such as
hemodialysis, surgeries, and in the setting of stroke, could have major
implications for maintaining healthy brain function," says Daniel Weiner,
M.D., a nephrologist at Tufts Medical Center (Tufts MC) and associate professor
of medicine at Tufts University School of Medicine (TUSM), who is a member of
the research team.
Josh Kornbluth, M.D., a neurologist
at Tufts MC and associate professor of medicine at TUSM, is also working with
Fantini to explore CHS's potential to assess the cerebrovascular state of
patients who suffer traumatic brain injury or stroke. They hope to test CHS
further among neurological critical care patients.
"Having data about local
cerebral blood flow and whether it is properly regulated can allow us to more
accurately develop individualized therapy and interventions instead of choosing
a 'one size fits all' approach to traumatic brain injury, stroke, or
subarachnoid hemorrhage," Kornbluth says..jpg)
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