Nothing here is of help to stroke survivors, none of us are clinically normal. Unless your doctor is willing to extrapolate this into a protocol for your use. Good luck with that.
Associations of Physical Activity and β-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults
Jennifer S. Rabin, PhD1,2; Hannah Klein, BSc3; Dylan R. Kirn, MPH3,4; et al
Aaron P. Schultz, PhD3,5; Hyun-Sik Yang, MD3,4; Olivia Hampton, BSc3; Shu Jiang, PhD3; Rachel F. Buckley, PhD3,4,6,7; Anand Viswanathan, MD, PhD8; Trey Hedden, PhD9; Jeremy Pruzin, MD3; Wai-Ying Wendy Yau, MD3; Edmarie Guzmán-Vélez, PhD1; Yakeel T. Quiroz, PhD1,3; Michael Properzi, BEng, BCompSc3; Gad A. Marshall, MD3,4; Dorene M. Rentz, PsyD3,4; Keith A. Johnson, MD3,4,5,10; Reisa A. Sperling, MD3,4,5; Jasmeer P. Chhatwal, MD, PhD3,4
JAMA Neurol. Published online July 16, 2019. doi:10.1001/jamaneurol.2019.1879
Key PointsQuestion
Does physical activity moderate the associations of β-amyloid
(Aβ) burden with longitudinal cognitive decline and neurodegeneration in
clinically normal older adults?
Findings In this study of 182 individuals, greater baseline physical activity attenuated Aβ-related cognitive decline and gray matter volume loss. In models adjusting for vascular risk, physical activity remained significant, and lower vascular risk was independently associated with slower Aβ-related cognitive decline and gray matter volume loss.
Meaning Interventional approaches that target both physical activity and vascular risk factors may have additive beneficial effects on delaying the progression of Alzheimer disease.
Importance
In the absence of disease-modifying therapies for Alzheimer
disease, there is a critical need to identify modifiable risk factors
that may delay the progression of Alzheimer disease.
Objective To examine whether physical activity moderates the association of β-amyloid (Aβ) burden with longitudinal cognitive decline and neurodegeneration in clinically normal individuals and to examine whether these associations are independent of vascular risk.
Design, Setting, and Participants This longitudinal observational study included clinically normal participants from the Harvard Aging Brain Study. Participants were required to have baseline Aβ positron emission tomography data, baseline medical data to quantify vascular risk, and longitudinal neuropsychological and structural magnetic resonance imaging data. Data were collected from April 2010 to June 2018. Data were analyzed from August to December 2018.
Main Outcomes and Measures Baseline physical activity was quantified with a pedometer (mean steps per day). Baseline Aβ burden was measured with carbon 11–labeled Pittsburgh Compound B positron emission tomography. Cognition was measured annually with the Preclinical Alzheimer Cognitive Composite (PACC; median [interquartile range] follow-up, 6.0 [4.3-6.3] years). Neurodegeneration was assessed with longitudinal structural magnetic resonance imaging (2 to 5 scans per participant; median [interquartile range] follow-up, 4.5 [3.0-5.0] years), with a focus on total gray matter volume and regional cortical thickness. Physical activity and Aβ burden were examined as interactive predictors of PACC decline and volume loss in separate linear mixed models, adjusting for age, sex, education, apolipoprotein E ε4 status, and, where appropriate, intracranial volume. Secondary models adjusted for vascular risk and its interaction with Aβ burden.
Results Of the 182 included participants, 103 (56.6%) were female, and the mean (SD) age was 73.4 (6.2) years. In models examining PACC decline and volume loss, there was a significant interaction of physical activity with Aβ burden, such that greater physical activity was associated with slower Aβ-related cognitive decline (β, 0.03; 95% CI, 0.02-0.05; P < .001) and volume loss (β, 482.07; 95% CI, 189.40-774.74; P = .002). Adjusting for vascular risk did not alter these associations. In these models, lower vascular risk was independently associated with slower Aβ-related PACC decline (β, −0.04; 95% CI, −0.06 to −0.02; P < .001) and volume loss (β, −483.41; 95% CI, −855.63 to −111.20; P = .01).
Conclusions and Relevance Greater physical activity and lower vascular risk independently attenuated the negative association of Aβ burden with cognitive decline and neurodegeneration in asymptomatic individuals. These findings suggest that engaging in physical activity and lowering vascular risk may have additive protective effects on delaying the progression of Alzheimer disease.
Findings In this study of 182 individuals, greater baseline physical activity attenuated Aβ-related cognitive decline and gray matter volume loss. In models adjusting for vascular risk, physical activity remained significant, and lower vascular risk was independently associated with slower Aβ-related cognitive decline and gray matter volume loss.
Meaning Interventional approaches that target both physical activity and vascular risk factors may have additive beneficial effects on delaying the progression of Alzheimer disease.
Abstract
Objective To examine whether physical activity moderates the association of β-amyloid (Aβ) burden with longitudinal cognitive decline and neurodegeneration in clinically normal individuals and to examine whether these associations are independent of vascular risk.
Design, Setting, and Participants This longitudinal observational study included clinically normal participants from the Harvard Aging Brain Study. Participants were required to have baseline Aβ positron emission tomography data, baseline medical data to quantify vascular risk, and longitudinal neuropsychological and structural magnetic resonance imaging data. Data were collected from April 2010 to June 2018. Data were analyzed from August to December 2018.
Main Outcomes and Measures Baseline physical activity was quantified with a pedometer (mean steps per day). Baseline Aβ burden was measured with carbon 11–labeled Pittsburgh Compound B positron emission tomography. Cognition was measured annually with the Preclinical Alzheimer Cognitive Composite (PACC; median [interquartile range] follow-up, 6.0 [4.3-6.3] years). Neurodegeneration was assessed with longitudinal structural magnetic resonance imaging (2 to 5 scans per participant; median [interquartile range] follow-up, 4.5 [3.0-5.0] years), with a focus on total gray matter volume and regional cortical thickness. Physical activity and Aβ burden were examined as interactive predictors of PACC decline and volume loss in separate linear mixed models, adjusting for age, sex, education, apolipoprotein E ε4 status, and, where appropriate, intracranial volume. Secondary models adjusted for vascular risk and its interaction with Aβ burden.
Results Of the 182 included participants, 103 (56.6%) were female, and the mean (SD) age was 73.4 (6.2) years. In models examining PACC decline and volume loss, there was a significant interaction of physical activity with Aβ burden, such that greater physical activity was associated with slower Aβ-related cognitive decline (β, 0.03; 95% CI, 0.02-0.05; P < .001) and volume loss (β, 482.07; 95% CI, 189.40-774.74; P = .002). Adjusting for vascular risk did not alter these associations. In these models, lower vascular risk was independently associated with slower Aβ-related PACC decline (β, −0.04; 95% CI, −0.06 to −0.02; P < .001) and volume loss (β, −483.41; 95% CI, −855.63 to −111.20; P = .01).
Conclusions and Relevance Greater physical activity and lower vascular risk independently attenuated the negative association of Aβ burden with cognitive decline and neurodegeneration in asymptomatic individuals. These findings suggest that engaging in physical activity and lowering vascular risk may have additive protective effects on delaying the progression of Alzheimer disease.
No comments:
Post a Comment