Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, July 20, 2019

Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches

I don't care about your use of big words and discussion/overview. Survivors want protocols for recovery.  GET THERE!  How the hell do we get stroke researchers to focus on the only reason for stroke research? 100% recovery for all. What stroke leaders do we need to convince that is the only goal?

Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches

  • Yörg Dillen
  • Hannelore Kemps
  • Pascal Gervois
  • Esther Wolfs
  • Annelies BronckaersEmail author
  1. 1.UHasselt, Hasselt UniversityBiomedical Research Institute (BIOMED) – Research Group of MorphologyDiepenbeekBelgium
Review
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Abstract

Adult neurogenesis in the subventricular zone is a topic of intense research, since it has vast implications for the fundamental understanding of the neurobiology of the brain and its potential to being harnessed for therapy in various neurological disorders. Investigation of adult neurogenesis has been complicated by the difficulties with characterization of neural stem cells in vivo. However, recent single-cell transcriptomic studies provide more detailed information on marker expression in neural stem cells and their neuronal lineage, which hopefully will result in a more unified discussion. Regulation of the multiple biological steps in adult neurogenesis comprises intrinsic mechanisms as well as extrinsic factors which together orchestrate the process. In this review, we describe the regulating factors and their cellular sources in the physiological condition and provide an overview of the regulating factors mediating stroke-induced stimulation of neurogenesis in the subventricular zone. While there is ongoing debate about the longevity of active post-natal neurogenesis in humans, the subventricular zone has the capacity to upregulate neurogenesis in response to ischemic stroke. Though, the stroke-induced neurogenesis in humans does not seem to translate into adequate functional recovery, which opens discussion about potential treatment strategies to harness this neuroregenerative response. Various therapeutic approaches are explored in preclinical and clinical studies to target endogenous neurogenesis of which some are discussed in this review.

Keywords

Adult neurogenesis Subventricular zone Ischemic stroke Neural stem cells Stroke therapy 
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Notes

Funding

This study was funded by grants of “Fonds voor Wetenschappelijk Onderzoek” (FWO) Vlaanderen and Research Funds of Hasselt University. Yörg Dillen is a predoctoral researcher of the “Fonds Wetenschappelijk Onderzoek” (FWO) Vlaanderen. Pascal Gervois, Esther Wolfs, Yörg Dillen and Annelies Bronckaers are funded by FWO grants 12U7718N, G0A7514N, 1134717N, FWO1522518. Hannelore Kemps is funded by the Special Research Fund (BOF) of Hasselt University” (Grant number 18NI06BOF).

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