Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Monday, January 15, 2018

Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals: A randomised controlled trial

Not to be done on your own, your doctor will take decades to get this into a protocol. Much easier to throw statin pills at you than have to measure curcumin doses.
https://www.mdlinx.com/internal-medicine/medical-news-article/2018/01/15/cholesterol-lipids-phytosterols-curcumin-hypercholesterolemia-cardiovascular/7500121/?
Metabolism | January 15, 2018
Ferguson JJA, et al. - Herein, experts probed into the effects of dietary intervention with phytosterols (PS) with or without curcumin on blood lipids (primary outcome) in hypercholesterolaemic subjects. Findings disclosed that curcumin plus phytosterol therapy imparted a complementary cholesterol-lowering effect, larger than phytosterol therapy alone. This data aided in the formulation of a single functional food containing both the active ingredients for enhanced lipid-lowering and compliance in such individuals.

Methods

  • Hypercholesterolaemic particpants were analyzed during this double-blinded, randomised, placebo-controlled, 2 × 2 factorial trial.
  • Candidates received either placebo (PL, no phytosterols or curcumin), phytosterols (PS, 2 g/d), curcumin (CC, 200 mg/d) or a combination of PS and curcumin (PS-CC, 2 g/d-200 mg/d respectively) for four weeks.
  • Fasting total cholesterol (TC), LDL-cholesterol, HDL-cholesterol, triglycerides (TG), TC-to-HDL-C ratio (TC:HDL-C) were included as the primary outcomes.
  • Anthropometrics and fasting blood glucose concentrations served as the secondary outcomes.

Results

  • This research was completed by 70 subjects, with a mean (±SEM) fasting TC concentration of 6.57 ± 0.13 mmol/L (PL, n = 18; PS, n = 17; CC, n = 18; PS-CC, n = 17).
  • A prominent lowering of TC, LDL-cholesterol and TC:HDL-C post-intervention (p < 0.05) was achieved by PS and PS-CC supplementation.
  • It was determined that the reductions from baseline in the PS group were 4.8% and 8.1% for TC and LDL-cholesterol respectively (p < 0.05).
  • Non-significant reduction (2.3% and 2.6%) was illustrated in TC and LDL-C respectively by CC.
  • Nevertheless, the PS-CC gave rise to a greater reduction in TC (11.0%) and LDL-cholesterol (14.4%) when compared to either of the treatments alone (p < 0.0001).
  • A substantially greater reduction was yielded in the PS-CC treatment compared to those for CC (p < 0.05) or PL (p < 0.01) alone.
  • Across all groups, plasma HDL-cholesterol and TG concentrations did not alter.
  • Findings did not disclose any adverse side effects.

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