Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, January 30, 2018

Tickling the brain with electrical stimulation improves memory, study shows

You may want this, tickling sounds so benign. Is it anything like tickling rat whiskers to improve their stroke rehabilitation? 

Tickling the brain with electrical stimulation improves memory, study shows

By Susan Barber Lindquist
ROCHESTER, Minn. — Tickling the brain with low-intensity electrical stimulation in a specific area can improve verbal short-term memory. Mayo Clinic researchers report their findings in Brain.
The researchers found word recall was enhanced with stimulation of the brain’s lateral temporal cortex, the regions on the sides of the head by the temples and ears. Patients recalled more words from a previously viewed list when low-amplitude electrical stimulation was delivered to the brain. One patient reported that it was easier to picture the words in his mind for remembering.
“The most exciting finding of this research is that our memory for language information can be improved by directly stimulating this underexplored brain area,” says Michal Kucewicz, Ph.D., a Mayo Clinic researcher in the Department of Neurology and co-first author. Dr. Kucewicz compares the stimulation to “tickling” the brain.
Memory impairments are a prevalent, costly problem in many brain diseases. Medication and behavioral therapies have limited effectiveness in many cases. “While electrical stimulation of the brain is emerging as potential therapy for a wide range of neurological and psychiatric diseases, little is known about its effect on memory,” says Gregory Worrell, M.D., Ph.D., a Mayo Clinic neurologist and senior author of the article.
The Mayo researchers are part of a multicenter collaboration led by Michael Kahana, Ph.D., University of Pennsylvania in Philadelphia. This collaboration includes seven academic medical centers.
“The next step for this project is to determine how to best apply electrical current in terms of the exact location within this area of the brain, timing and parameters of stimulation,” says Brent Berry, M.D., Ph.D., a Mayo Clinic researcher in the Department of Physiology and Biomedical Engineering and co-first author.
In this Brain paper, Drs. Kucewicz and Berry, and colleagues focused their study on four areas of the brain known to support memory for facts and events that can be consciously recalled.
The memory testing was done with patients undergoing evaluation for surgery to address seizures. These patients agreed to have their memory investigated using the electrodes implanted in their brains for surgical evaluation. It is common for people with epilepsy to have memory problems because the brain circuits that underlie memory function often are affected by epilepsy.
In the study, patients were instructed to read a list of words ─ one at a time ─ from a computer screen. Electrical stimulation was applied some of this time. Patients then attempted to freely recall the words in any order.
Among 22 patients, the researchers found enhanced memory performance in the four patients with stimulation of the lateral temporal cortex but not among those with the other brain regions stimulated.
“These findings may lead to new stimulation devices that treat deficits in memory and cognition,” says Jamie Van Gompel, M.D., a Mayo Clinic neurosurgeon specializing in brain sitmulation and an author in the study.
The authors note study limitations include pain and seizure medications that may affect patient performance, the hospital setting that may disrupt patients’ sleep and wake cycles, and the fact that epilepsy affects memory.
Additional authors of the study are Laura R. Miller, Mayo Clinic; Fatemeh Khadjevand, M.D., Mayo Clinic; Youssef Ezzyat, Ph.D., University of Pennsylvania; Joel Stein, Ph.D., University of Pennsylvania; Vaclav Kremen, Ph.D., Mayo Clinic and Czech Technical University; Benjamin Brinkmann, Ph.D., Mayo Clinic; Paul Wanda, Ph.D., University of Pennsylvania; Michael Sperling, M.D., Jefferson University Hospitals; Richard Gorniak, M.D., Jefferson University Hospitals; Kathryn Davis, M.D., University of Pennsylvania; Barbara Jobst, M.D., Dartmouth-Hitchcock Medical Center; Robert Gross, Ph.D., Emory University; Bradley Lega, Ph.D., University of Texas Southwestern Medical Center; Squire Stead, M.D., Ph.D., Mayo Clinic; and Daniel Rizzuto, Ph.D., University of Pennsylvania.
The research was funded in part by Defense Advanced Research Project Agency’s Restoring Active Memory program.
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About Mayo Clinic
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