Deans' stroke musings: Blood Glutamate Levels Are Closely Related to Acute Lung Injury and Prognosis after Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, January 23, 2018

Blood Glutamate Levels Are Closely Related to Acute Lung Injury and Prognosis after Stroke

So you've identified a problem but offered no solution. You stroke survivors are going to have to solve this on their own.
https://www.frontiersin.org/articles/10.3389/fneur.2017.00755/full?

Wei Bai^1†,

Wei Li^2†,

Ya-Lei Ning¹,

Ping Li¹,

Yan Zhao¹,

Nan Yang¹,

Yu-Lin Jiang¹,

Ze-Ping Liang³,

Dong-Po Jiang³,

Ying Wang²,

Meng Zhang²* and

Yuan-Guo Zhou¹*

¹Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China
²Department of Neurology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China
³Department of ICU, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China

Background: Acute lung injury (ALI) is a serious complication of stroke that occurs with a high incidence. Our preclinical results indicated that ALI might be related to blood glutamate levels after brain injury. The purpose of this study was to assess dynamic changes in blood glutamate levels in patients with stroke and to determine the correlation between blood glutamate levels, ALI, and long-term prognosis after stroke.

Methods: Venous blood samples were collected from controls and patients with stroke at admission and on the third and seventh day after the onset of stroke. Patients were followed for 3 months. The correlations among blood glutamate levels, severities of stroke and ALI, and long-term outcomes were analyzed, and the predictive values of blood glutamate levels and severity scores for ALI were assessed.

Results: In this study, a total of 384 patients with stroke were enrolled, with a median age of 59 years. Patients showed significantly increased blood glutamate levels within 7 days of stroke onset (p < 0.05), and patients with more severe injuries showed higher blood glutamate levels. Moreover, blood glutamate levels were closely related to the occurrence (adjusted odds ratio, 3.022, p = 0.003) and severity (p < 0.001) of ALI and the long-term prognosis after stroke (p < 0.05), and they were a more accurate predictor of ALI than the more commonly used severity scores (p < 0.01).

Conclusion: These results indicated that an increased blood glutamate level was closely related to the development of ALI and a poor prognosis after stroke.

Clinical Trial Registration: http://www.chictr.org.cn, identifier ChiCTR-RPC-15006770.