Way beyond my pay grade to understand and obviously there was no consideration to make it readable for stroke survivors. So unless your doctor can decipher this and put it into a consent for treatment form, this was a total waste of time.
Intravenous thrombolysis pretreatment and other predictors of infarct in a new previously unaffected territory (INT) in ELVO strokes treated with mechanical thrombectomy
Abstract
Introduction
One uncommon complication of mechanical thrombectomy (MT) is an infarct
in a new previously unaffected territory (infarct in new territory
(INT)).
Objective To evaluate the predictors of INT with special focus on intravenous thrombolysis(IVT)pretreatmentbefore MT.
Methods
Consecutive patients with emergent large vessel occlusion (ELVO)
treated with MT during a 5-year period were evaluated. INT was defined
using standardized methodology proposed by ESCAPE investigators. The
predictors of INT and its impact on outcomes were investigated.
Results
A total of 419 consecutive patients with ELVO received MT (mean age
64±15 years, 50% men, median baseline National Institutes of Health
Stroke Scale score 16 points (IQR 11–20), 69% pretreated with IVT). The
incidence of INT was lower in patients treated with combination therapy
(IVTandMT) than in patients treated with MT alone, respectively (10% vs
20%; p=0.011). The INT group had more patients with posterior
circulation occlusions than the group without INT (28% vs 10%,
respectively; p<0.001). The rates of 3-month functional independence
were lower in patients with INT (30% vs 50%; p=0.007). IVT pretreatment
was not independently related to INT (OR=0.75; 95% CI 0.32 to 1.76), and
INT did not emerge as an independent predictor of 3-month functional
independence (OR=0.69; 95% CI 0.29 to 1.62) on multivariable logistic
regression models. Location of posterior circulation occlusion was
independently associated with a higher odds of INT (OR=3.33; 95% CI 1.43
to 7.69; p=0.005).
Conclusions
IVT pretreatment is not independently associated with a lower
likelihood of INT in patients with ELVO treated with MT. Patients with
ELVO with posterior circulation occlusion are more likely to have INT
after MT.
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