Deans' stroke musings: BDNF: New Views of an Old Player in Traumatic Brain Injury

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, April 26, 2023

BDNF: New Views of an Old Player in Traumatic Brain Injury

If your doctor doesn't have EXACT PROTOCOLS on BDNF application and use, you don't have a functioning stroke doctor. I' don't know what you have but you need to start asking some serious questions about the competency of your stroke medical 'professionals'. And yes professionals is in scare quotes for a reason.

BDNF (165 posts to April 2011)
- Val66Met (1 post to September 2017)
BDNF Val66Met (3 posts to May 2020)

The latest here:

BDNF: New Views of an Old Player in Traumatic Brain Injury

Lauren P. Giesler https://orcid.org/0000-0002-0209-6427, Richelle Mychasiuk https://orcid.org/0000-0001-5291-5083, and Stuart J. McDonald stuart.mcdonald@monash.eduView all authors and affiliations

OnlineFirst

https://doi.org/10.1177/10738584231164918

Abstract

Traumatic brain injury is a common health problem affecting millions of people each year. BDNF has been investigated in the context of traumatic brain injury due to its crucial role in maintaining brain homeostasis. Val66Met is a functional single-nucleotide polymorphism that results in a valine-to-methionine amino acid substitution at codon 66 in the BDNF prodomain, which ultimately reduces secretion of BDNF. Here, we review experimental animal models as well as clinical studies investigating the role of the Val66Met single-nucleotide polymorphism in traumatic brain injury outcomes, including cognitive function, motor function, neuropsychiatric symptoms, and nociception. We also review studies investigating the role of BDNF on traumatic brain injury pathophysiology as well as circulating BDNF as a biomarker of traumatic brain injury.