Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, April 29, 2014

Melatonin plus treadmill exercise synergistically promotes neurogenesis and reduce apoptosis in focal cerebral ischemic rats (877.17)

This would be so simple to construct a human clinical trial on this. Why hasn't your doctor started it up yet? Melatonin is easily available. However, don't do this, you know how dangerous doing anything without your doctors ok is. Side effects here:
And treadmills are dammed dangerous.
http://www.fasebj.org/content/28/1_Supplement/877.17.short
  1. Yonggeun Hong2,1
+ Author Affiliations
  1. 1Cardiovascular & Metabolic Disease Center, College of Biomedical Science & Engineering, Inje University Gimhae Korea, Republic of
  2. 2Department of Rehabilitation Science in Interdisciplinary PhD Program Graduate School of Inje University Gimhae Korea, Republic of

Abstract

Ischemic stroke results from sudden decrease or loss of blood flow to the brain, resulting in damage to neurological function and neuronal networks, cognition. The purpose of this study, we determined whether melatonin and/or treadmill exercise could induce neurogenesis, thereby promoting functional recovery in ischemic brain. Following the MCAo, Sprague-Dawley (SD) rats were randomly divided into control (Con), MCAo, MCAo+Exercise (MCAo+Ex), MCAo+Melatonin (MCAo+MT), Melatonin combined Exercise in MCAo (MCAo+MT+Ex). The 8 week old SD rats were treated twice daily with melatonin (10 mg/kg) at 17:00 and 19:00, and trained twice daily with treadmill exercise (20 m/min, 6 days/week) at 17:00 and 22:00. At the Golgi-cox staining, dendrite density in the MCAo+MT+Ex group was higher than in MCAo group. We confirmed that MCAo+MT+ME group was significantly recovered the neurological symptom in behavioral assessment (p<.01). Moreover, MCAo+MT and MCAo+MT+Ex were significantly increased both DCx and GFAP mRNA expression. In conclusion, we suggest that melatonin with and without treadmill exercise intervention enhanced neurogenesis and neuronal cell reconstruction in damaged brain lesions, thereby induced improvement of neurological dysfunction in animal model. Key words: Melatonin, Treadmill exercise, Neurogenesis, Apoptosis, Focal cerebral ischemia
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1 comment:

  1. AmyMay 1, 2014 at 1:40 PM

    Whoa. It would have been nice if my doctor told me I have been doing something very right for the last 3 years.

    ReplyDelete

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