Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults
- Claire E. Sexton, DPhil,
- Andreas B. Storsve, MSc,
- Kristine B. Walhovd, PhD,
- Heidi Johansen-Berg, DPhil and
- Anders M. Fjell, PhD
- Correspondence to Dr. Sexton: claire.sexton@ndcn.ox.ac.uk
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10.1212/WNL.0000000000000774Neurology
- Abstract
- Full Text (PDF)
Abstract
Objective: To
examine the relationship between sleep quality and cortical and
hippocampal volume and atrophy within a community-based
sample, explore the influence of age on results,
and assess the possible confounding effects of physical activity
levels,
body mass index (BMI), and blood pressure.
Methods: In 147
community-dwelling adults (92 female; age 53.9 ± 15.5 years), sleep
quality was measured using the Pittsburgh Sleep
Quality Index and correlated with
cross-sectional measures of volume and longitudinal measures of atrophy
derived from MRI
scans separated by an average of 3.5 years.
Exploratory post hoc analysis compared correlations between different
age groups
and included physical activity, BMI, and blood
pressure as additional covariates.
Results: Poor sleep
quality was associated with reduced volume within the right superior
frontal cortex in cross-sectional analyses,
and an increased rate of atrophy within
widespread frontal, temporal, and parietal regions in longitudinal
analyses. Results
were largely driven by correlations within
adults over the age of 60, and could not be explained by variation in
physical
activity, BMI, or blood pressure. Sleep quality
was not associated with hippocampal volume or atrophy.
Conclusions: We found that longitudinal measures of cortical atrophy were widely correlated with sleep quality. Poor sleep quality may be a cause or a consequence of brain atrophy, and future studies examining the effect of interventions that improve sleep quality on rates of atrophy may hold key insights into the direction of this relationship
The conclusions in this article, however qualified these conclusions may be -- like many facts essential to stroke rehabilitation -- are insufficiently addressed by MDs and other medical professionals. Indeed, the vital importance of sleep, and rest in general, is often ignored or taken for granted.
ReplyDeleteAnd if we had a stroke association worth its salt we could go to that and be confident that all these questions would be addressed.
DeleteDean, the mandate of Heart and Stroke Foundation is to support health education and research not to support stroke survivors. They do have lots of generic pamphlets about stroke though. Most people assume that HSN of Canada supports survivors like Parkinson ' s or ALS. However support for survivors is not part of their mandate. I think that is the case with the American Stroke Assn. As well.
DeleteThe problem is that we have no stroke protocols for how to address sleep problems post-stroke and no way to get someone to create them. Unless we expect every single stroke doctor in the world to do this work. That will never occur, so everyone is waiting for somebody else to solve the problem.
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