Deans' stroke musings: Type AB Blood? You May Be More Prone to Memory Loss

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, September 11, 2014

Type AB Blood? You May Be More Prone to Memory Loss

So is your doctor a shoot from the hip person and immediately ascribes your memory loss post-stroke to the stroke? Ask about the bias of Occams' razor and whether or not another reason might be the cause. You will need to force your doctor to think outside the box. At least I'm O negative.
Article here:
https://www.yahoo.com/health/type-ab-blood-you-may-be-more-prone-to-memory-loss-97230693847.html

Research here:
ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

Kristine S. Alexander, PhD, MCR,
Neil A. Zakai, MD, MSc,
Sarah Gillett, PhD,
Leslie A. McClure, PhD,
Virginia Wadley, PhD,
Fred Unverzagt, PhD and
Mary Cushman, MD, MSc

+Show Affiliations

Correspondence to Dr. Cushman: mary.cushman@uvm.edu

Published online before print September 10, 2014, doi: 10.1212/WNL.0000000000000844 Neurology 10.1212/WNL.0000000000000844

Abstract
Full Text (PDF)

Abstract

Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.

Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.

Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15–2.90; and 1.24, 95% CI 1.10–1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119–165) compared with O (104 IU/dL; 95% CI 101–107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation −30% to 68%).

Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.